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Murcko scaffold

1-(1,3-Benzodioxol-5-ylmethyl)-4-benzylpiperazine scaffold

44 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
44
With full pages
13
Scaffold SMILES

c1ccc(CN2CCN(Cc3ccc4c(c3)OCO4)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1,3-Benzodioxol-5-ylmethyl)-4-benzylpiperazine page
Murcko scaffold c1ccc(CN2CCN(Cc3ccc4c(c3)OCO4)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

1-[(7-Methoxy-1,3-benzodioxol-5-yl)methyl]-4-[(3-methylphenyl)methyl]piperazine chemical structure, C21H26N2O3, CAS 423154-82-9
1-[(7-Methoxy-1,3-benzodioxol-5-yl)methyl]-4-[(3-methylphenyl)methyl]piperazine
CAS 423154-82-9C21H26N2O3
1-(2-Fluoro-benzyl)-4-(7-methoxy-benzo[1,3]dioxol-5-ylmethyl)-piperazine chemical structure, C20H23FN2O3, CAS 438480-99-0
1-(2-Fluoro-benzyl)-4-(7-methoxy-benzo[1,3]dioxol-5-ylmethyl)-piperazine
CAS 438480-99-0C20H23FN2O3
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2-methoxybenzyl)piperazine chemical structure, C20H24N2O3, CAS 414891-50-2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2-methoxybenzyl)piperazine
CAS 414891-50-2C20H24N2O3
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3-chlorobenzyl)piperazine chemical structure, C19H21ClN2O2, CAS 414872-65-4
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3-chlorobenzyl)piperazine
CAS 414872-65-4C19H21ClN2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-chlorobenzyl)piperazine chemical structure, C19H21ClN2O2, CAS 414884-92-7
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-chlorobenzyl)piperazine
CAS 414884-92-7C19H21ClN2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-ethylbenzyl)piperazine chemical structure, C21H26N2O2, CAS 414880-66-3
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-ethylbenzyl)piperazine
CAS 414880-66-3C21H26N2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2-fluorobenzyl)piperazine chemical structure, C19H21FN2O2, CAS 414888-60-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2-fluorobenzyl)piperazine
CAS 414888-60-1C19H21FN2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-fluorobenzyl)piperazine chemical structure, C19H21FN2O2, CAS 414884-08-5
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-fluorobenzyl)piperazine
CAS 414884-08-5C19H21FN2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,4-difluorobenzyl)piperazine chemical structure, C19H20F2N2O2, CAS 414894-08-9
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,4-difluorobenzyl)piperazine
CAS 414894-08-9C19H20F2N2O2
1-Benzyl-4-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]piperazine chemical structure, C20H24N2O3, CAS 415703-19-4
1-Benzyl-4-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]piperazine
CAS 415703-19-4C20H24N2O3
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3,4-difluorophenyl)methyl]piperazine chemical structure, C19H20F2N2O2, CAS 376606-20-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3,4-difluorophenyl)methyl]piperazine
CAS 376606-20-1C19H20F2N2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3-methoxyphenyl)methyl]piperazine chemical structure, C20H24N2O3, CAS 355396-42-8
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3-methoxyphenyl)methyl]piperazine
CAS 355396-42-8C20H24N2O3
1-(1,3-Benzodioxol-5-ylmethyl)-4-benzylpiperazine chemical structure, C19H22N2O2, CAS 414876-23-6
1-(1,3-Benzodioxol-5-ylmethyl)-4-benzylpiperazine
CAS 414876-23-6C19H22N2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methoxybenzyl)piperazine chemical structure, C20H24N2O3, CAS 355396-07-5
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methoxybenzyl)piperazine
CAS 355396-07-5C20H24N2O3
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methylbenzyl)piperazine chemical structure, C20H24N2O2, CAS 414883-17-3
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methylbenzyl)piperazine
CAS 414883-17-3C20H24N2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-propan-2-ylphenyl)methyl]piperazine chemical structure, C22H28N2O2, CAS 5264-98-2
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-propan-2-ylphenyl)methyl]piperazine
CAS 5264-98-2C22H28N2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-methylsulfanylphenyl)methyl]piperazine chemical structure, C20H24N2O2S, CAS 355396-49-5
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-methylsulfanylphenyl)methyl]piperazine
CAS 355396-49-5C20H24N2O2S
4-[[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]methyl]-N,N-dimethylaniline chemical structure, C21H27N3O2, CAS 414886-76-3
4-[[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]methyl]-N,N-dimethylaniline
CAS 414886-76-3C21H27N3O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-ethoxybenzyl)piperazine chemical structure, C21H26N2O3, CAS 331976-94-4
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-ethoxybenzyl)piperazine
CAS 331976-94-4C21H26N2O3
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,4-dichlorobenzyl)piperazine chemical structure, C19H20Cl2N2O2, CAS 331976-58-0
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,4-dichlorobenzyl)piperazine
CAS 331976-58-0C19H20Cl2N2O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]piperazine chemical structure, C21H26N2O4, CAS 355396-05-3
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]piperazine
CAS 355396-05-3C21H26N2O4
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3-nitrophenyl)methyl]piperazine chemical structure, C19H21N3O4, CAS 355396-45-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3-nitrophenyl)methyl]piperazine
CAS 355396-45-1C19H21N3O4
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(2,3-dimethoxyphenyl)methyl]piperazine chemical structure, C21H26N2O4, CAS 355396-59-7
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(2,3-dimethoxyphenyl)methyl]piperazine
CAS 355396-59-7C21H26N2O4
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-bromobenzyl)piperazine chemical structure, C19H21BrN2O2, CAS 355396-68-8
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-bromobenzyl)piperazine
CAS 355396-68-8C19H21BrN2O2