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Murcko scaffold

Piperazine, 1-benzoyl-4-piperonyl- scaffold

50 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
50
With full pages
26
Scaffold SMILES

O=C(c1ccccc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine, 1-benzoyl-4-piperonyl- page
Murcko scaffold O=C(c1ccccc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

Benzoic acid, 2,5-dimethoxy-4-(4-piperonylpiperazin-1-yl-carbonyl)-, ethyl ester, methanesulfonate chemical structure, C25H32N2O10S, CAS 73713-62-9
Benzoic acid, 2,5-dimethoxy-4-(4-piperonylpiperazin-1-yl-carbonyl)-, ethyl ester, methanesulfonate
CAS 73713-62-9C25H32N2O10S
Peralopride chemical structure, C20H22ClN3O4, CAS 57083-89-3
Peralopride
CAS 57083-89-3C20H22ClN3O4
Phenol, 2-(4-piperonylpiperazin-1-ylcarbonyl)-, hydrochloride chemical structure, C19H21ClN2O4, CAS 3459-25-4
Phenol, 2-(4-piperonylpiperazin-1-ylcarbonyl)-, hydrochloride
CAS 3459-25-4C19H21ClN2O4
Piperazine, 1-(3,4,5-trimethoxybenzoyl)-4-piperonyl-, hydrochloride chemical structure, C22H27ClN2O6, CAS 3398-27-4
Piperazine, 1-(3,4,5-trimethoxybenzoyl)-4-piperonyl-, hydrochloride
CAS 3398-27-4C22H27ClN2O6
Aniline, 4-(4-piperonylpiperazin-1-ylcarbonyl)- chemical structure, C19H21N3O3, CAS 3398-28-5
Aniline, 4-(4-piperonylpiperazin-1-ylcarbonyl)-
CAS 3398-28-5C19H21N3O3
Piperazine, 1-benzoyl-4-piperonyl- chemical structure, C19H20N2O3, CAS 6761-59-7
Piperazine, 1-benzoyl-4-piperonyl-
CAS 6761-59-7C19H20N2O3
Phenol, 2,6-dimethoxy-4-(4-piperonylpiperazin-1-ylcarbonyl)-, hydrochloride chemical structure, C21H25ClN2O6, CAS 6761-68-8
Phenol, 2,6-dimethoxy-4-(4-piperonylpiperazin-1-ylcarbonyl)-, hydrochloride
CAS 6761-68-8C21H25ClN2O6
Phenol, 4-(4-piperonylpiperazin-1-ylcarbonyl)- chemical structure, C19H20N2O4, CAS 6854-34-8
Phenol, 4-(4-piperonylpiperazin-1-ylcarbonyl)-
CAS 6854-34-8C19H20N2O4
[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-(2,6-dimethoxyphenyl)methanone chemical structure, C21H24N2O5, CAS 346704-61-8
[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-(2,6-dimethoxyphenyl)methanone
CAS 346704-61-8C21H24N2O5
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(2-methoxyphenyl)methanone chemical structure, C20H22N2O4, CAS 371115-68-3
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(2-methoxyphenyl)methanone
CAS 371115-68-3C20H22N2O4
(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)(p-tolyl)methanone chemical structure, C20H22N2O3, CAS 6602-00-2
(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)(p-tolyl)methanone
CAS 6602-00-2C20H22N2O3
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(4-fluorophenyl)methanone chemical structure, C19H19FN2O3, CAS 326022-29-1
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(4-fluorophenyl)methanone
CAS 326022-29-1C19H19FN2O3
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(3-fluorophenyl)methanone chemical structure, C19H19FN2O3, CAS 354535-77-6
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(3-fluorophenyl)methanone
CAS 354535-77-6C19H19FN2O3
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(2-fluorophenyl)methanone chemical structure, C19H19FN2O3, CAS 346704-58-3
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(2-fluorophenyl)methanone
CAS 346704-58-3C19H19FN2O3
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(5-chloro-2-nitrophenyl)methanone chemical structure, C19H18ClN3O5, CAS 546096-78-0
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(5-chloro-2-nitrophenyl)methanone
CAS 546096-78-0C19H18ClN3O5
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-isopropylbenzoyl)piperazine chemical structure, C22H26N2O3, CAS 546091-03-6
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-isopropylbenzoyl)piperazine
CAS 546091-03-6C22H26N2O3
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(2,5-dichlorophenyl)methanone chemical structure, C19H18Cl2N2O3, CAS 349438-20-6
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(2,5-dichlorophenyl)methanone
CAS 349438-20-6C19H18Cl2N2O3
[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-[2-(ethylthio)phenyl]methanone chemical structure, C21H24N2O3S, CAS 663188-00-9
[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-[2-(ethylthio)phenyl]methanone
CAS 663188-00-9C21H24N2O3S
N-[2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide chemical structure, C21H25N3O5S, CAS 706767-96-6
N-[2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazine-1-carbonyl]phenyl]-N-methylmethanesulfonamide
CAS 706767-96-6C21H25N3O5S
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(3,5-dimethoxyphenyl)methanone chemical structure, C21H24N2O5, CAS 346725-51-7
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-(3,5-dimethoxyphenyl)methanone
CAS 346725-51-7C21H24N2O5
(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-(3,4-dimethyl-phenyl)-methanone chemical structure, C21H24N2O3, CAS 349618-75-3
(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-(3,4-dimethyl-phenyl)-methanone
CAS 349618-75-3C21H24N2O3
(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-(4-ethoxy-phenyl)-methanone chemical structure, C21H24N2O4, CAS 349619-17-6
(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-(4-ethoxy-phenyl)-methanone
CAS 349619-17-6C21H24N2O4
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl][4-(dimethylamino)phenyl]methanone chemical structure, C21H25N3O3, CAS 349622-69-1
[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl][4-(dimethylamino)phenyl]methanone
CAS 349622-69-1C21H25N3O3
N-[2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazine-1-carbonyl)-phenyl]-acetamide chemical structure, C21H23N3O4, CAS 349623-45-6
N-[2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazine-1-carbonyl)-phenyl]-acetamide
CAS 349623-45-6C21H23N3O4