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Murcko scaffold

1-Benzenesulfonyl-4-benzo[1,3]dioxol-5-ylmethyl-piperazine scaffold

78 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
78
With full pages
22
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzenesulfonyl-4-benzo[1,3]dioxol-5-ylmethyl-piperazine page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 78 chemicals

1-(1,3-Benzodioxol-5-ylmethyl)-4-{[3-(trifluoromethyl)phenyl]sulfonyl}piperazine chemical structure, C19H19F3N2O4S, CAS 305859-63-6
1-(1,3-Benzodioxol-5-ylmethyl)-4-{[3-(trifluoromethyl)phenyl]sulfonyl}piperazine
CAS 305859-63-6C19H19F3N2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3-chlorophenyl)sulfonyl]piperazine chemical structure, C18H19ClN2O4S, CAS 667912-17-6
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(3-chlorophenyl)sulfonyl]piperazine
CAS 667912-17-6C18H19ClN2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,6-difluorophenyl)sulfonylpiperazine chemical structure, C18H18F2N2O4S, CAS 667912-19-8
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,6-difluorophenyl)sulfonylpiperazine
CAS 667912-19-8C18H18F2N2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,5-dichloro-4-methoxyphenyl)sulfonylpiperazine chemical structure, C19H20Cl2N2O5S, CAS 667893-13-2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,5-dichloro-4-methoxyphenyl)sulfonylpiperazine
CAS 667893-13-2C19H20Cl2N2O5S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dichloro-2-methoxyphenyl)sulfonylpiperazine chemical structure, C19H20Cl2N2O5S, CAS 667893-14-3
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dichloro-2-methoxyphenyl)sulfonylpiperazine
CAS 667893-14-3C19H20Cl2N2O5S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3-bromo-4-methoxyphenyl)sulfonylpiperazine chemical structure, C19H21BrN2O5S, CAS 531541-90-9
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3-bromo-4-methoxyphenyl)sulfonylpiperazine
CAS 531541-90-9C19H21BrN2O5S
1-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-((3,4-dimethoxyphenyl)sulfonyl)piperazine chemical structure, C20H24N2O6S, CAS 278782-75-5
1-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-((3,4-dimethoxyphenyl)sulfonyl)piperazine
CAS 278782-75-5C20H24N2O6S
3-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)sulfonyl)benzoic acid chemical structure, C19H20N2O6S, CAS 307513-29-7
3-((4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)sulfonyl)benzoic acid
CAS 307513-29-7C19H20N2O6S
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(2,5-dichlorophenyl)sulfonyl]piperazine chemical structure, C18H18Cl2N2O4S, CAS 349625-52-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(2,5-dichlorophenyl)sulfonyl]piperazine
CAS 349625-52-1C18H18Cl2N2O4S
1-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-((2,3,4-trimethylphenyl)sulfonyl)piperazine chemical structure, C21H26N2O4S, CAS 694516-77-3
1-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-((2,3,4-trimethylphenyl)sulfonyl)piperazine
CAS 694516-77-3C21H26N2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methoxy-3-methylphenyl)sulfonylpiperazine chemical structure, C20H24N2O5S, CAS 634171-78-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methoxy-3-methylphenyl)sulfonylpiperazine
CAS 634171-78-1C20H24N2O5S
1-Benzo[1,3]dioxol-5-ylmethyl-4-(4-ethoxy-benzenesulfonyl)-piperazine chemical structure, C20H24N2O5S, CAS 641601-84-5
1-Benzo[1,3]dioxol-5-ylmethyl-4-(4-ethoxy-benzenesulfonyl)-piperazine
CAS 641601-84-5C20H24N2O5S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methoxy-2,3-dimethylphenyl)sulfonylpiperazine chemical structure, C21H26N2O5S, CAS 691381-46-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-(4-methoxy-2,3-dimethylphenyl)sulfonylpiperazine
CAS 691381-46-1C21H26N2O5S
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-methoxy-2,5-dimethylphenyl)sulfonyl]piperazine chemical structure, C21H26N2O5S, CAS 701931-41-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-methoxy-2,5-dimethylphenyl)sulfonyl]piperazine
CAS 701931-41-1C21H26N2O5S
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(5-chloro-2-methoxyphenyl)sulfonyl]piperazine chemical structure, C19H21ClN2O5S, CAS 701948-59-6
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(5-chloro-2-methoxyphenyl)sulfonyl]piperazine
CAS 701948-59-6C19H21ClN2O5S
1-Benzo[1,3]dioxol-5-ylmethyl-4-(4-chloro-3-methoxy-benzenesulfonyl)-piperazine chemical structure, C19H21ClN2O5S, CAS 701275-88-9
1-Benzo[1,3]dioxol-5-ylmethyl-4-(4-chloro-3-methoxy-benzenesulfonyl)-piperazine
CAS 701275-88-9C19H21ClN2O5S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dimethylphenyl)sulfonylpiperazine chemical structure, C20H24N2O4S, CAS 701973-23-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3,4-dimethylphenyl)sulfonylpiperazine
CAS 701973-23-1C20H24N2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,5-dimethoxyphenyl)sulfonylpiperazine chemical structure, C20H24N2O6S, CAS 497060-93-2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(2,5-dimethoxyphenyl)sulfonylpiperazine
CAS 497060-93-2C20H24N2O6S
1-Benzenesulfonyl-4-benzo[1,3]dioxol-5-ylmethyl-piperazine chemical structure, C18H20N2O4S, CAS 346725-52-8
1-Benzenesulfonyl-4-benzo[1,3]dioxol-5-ylmethyl-piperazine
CAS 346725-52-8C18H20N2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-chlorophenyl)sulfonyl]piperazine chemical structure, C18H19ClN2O4S, CAS 326907-59-9
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-chlorophenyl)sulfonyl]piperazine
CAS 326907-59-9C18H19ClN2O4S
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(2,4,6-trimethylbenzenesulfonyl)piperazine chemical structure, C21H26N2O4S, CAS 349624-04-0
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(2,4,6-trimethylbenzenesulfonyl)piperazine
CAS 349624-04-0C21H26N2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-bromophenyl)sulfonyl]piperazine chemical structure, C18H19BrN2O4S, CAS 349614-68-2
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-bromophenyl)sulfonyl]piperazine
CAS 349614-68-2C18H19BrN2O4S
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-fluorophenyl)sulfonyl]piperazine chemical structure, C18H19FN2O4S, CAS 326889-82-1
1-(1,3-Benzodioxol-5-ylmethyl)-4-[(4-fluorophenyl)sulfonyl]piperazine
CAS 326889-82-1C18H19FN2O4S
N-[4-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C20H23N3O5S, CAS 349610-95-3
N-[4-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]sulfonylphenyl]acetamide
CAS 349610-95-3C20H23N3O5S