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Murcko scaffold

1-(1,3-Benzodioxol-5-ylcarbonyl)-4-(phenylsulfonyl)piperazine scaffold

5 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
5
With full pages
4
Scaffold SMILES

O=C(c1ccc2c(c1)OCO2)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1,3-Benzodioxol-5-ylcarbonyl)-4-(phenylsulfonyl)piperazine page
Murcko scaffold O=C(c1ccc2c(c1)OCO2)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 5 of 5 chemicals

1-(1,3-Benzodioxol-5-ylcarbonyl)-4-(phenylsulfonyl)piperazine chemical structure, C18H18N2O5S, CAS 775299-35-9
1-(1,3-Benzodioxol-5-ylcarbonyl)-4-(phenylsulfonyl)piperazine
CAS 775299-35-9C18H18N2O5S
Benzo[1,3]dioxol-5-yl-[4-(4-chloro-benzenesulfonyl)-piperazin-1-yl]-methanone chemical structure, C18H17ClN2O5S, CAS 878418-21-4
Benzo[1,3]dioxol-5-yl-[4-(4-chloro-benzenesulfonyl)-piperazin-1-yl]-methanone
CAS 878418-21-4C18H17ClN2O5S
Benzo[1,3]dioxol-5-yl-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone chemical structure, C19H20N2O5S, CAS 878418-16-7
Benzo[1,3]dioxol-5-yl-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-methanone
CAS 878418-16-7C19H20N2O5S
1,3-Benzodioxol-5-yl-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]methanone chemical structure, C21H24N2O5S, CAS 878724-36-8
1,3-Benzodioxol-5-yl-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]methanone
CAS 878724-36-8C21H24N2O5S
1-(1,3-Benzodioxol-5-ylcarbonyl)-4-[(3,4-dimethylphenyl)sulfonyl]piperazine chemical structure, C20H22N2O5S, CAS 878724-40-4
1-(1,3-Benzodioxol-5-ylcarbonyl)-4-[(3,4-dimethylphenyl)sulfonyl]piperazine
CAS 878724-40-4C20H22N2O5S