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Murcko scaffold

Ring system with 3 rings and 19 atoms

17 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 17
With full pages: 3

Scaffold SMILES

O=C(CSc1nnc(C2CC2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(C2CC2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

2-(5-Cyclopropyl-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl)-N-p-tolyl-acetamide chemical structure, C16H20N4OS, CAS 432540-93-7

2-(5-Cyclopropyl-4-ethyl-4H-[1,2,4]triazol-3-ylsulfanyl)-N-p-tolyl-acetamide

CAS 432540-93-7C₁₆H₂₀N₄OS

2-[(4-Allyl-5-cyclopropyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methylphenyl)acetamide chemical structure, C17H20N4OS, CAS 433232-48-5

2-[(4-Allyl-5-cyclopropyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-methylphenyl)acetamide

CAS 433232-48-5C₁₇H₂₀N₄OS

N-(4-Chlorophenyl)-2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C15H17ClN4OS, CAS 578744-14-6

N-(4-Chlorophenyl)-2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide

CAS 578744-14-6C₁₅H₁₇ClN₄OS

2-[(5-Cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(dimethylamino)phenyl]acetamide chemical structure, C17H23N5OS, CAS 603981-52-8

2-[(5-Cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(dimethylamino)phenyl]acetamide

CAS 603981-52-8C₁₇H₂₃N₅OS

2-[(5-Cyclopropyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylphenyl)acetamide chemical structure, C15H18N4OS, CAS 588676-67-9

2-[(5-Cyclopropyl-4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methylphenyl)acetamide

CAS 588676-67-9C₁₅H₁₈N₄OS

2-[(5-Cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide chemical structure, C16H20N4O2S, CAS 603981-46-0

2-[(5-Cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-methoxyphenyl)acetamide

CAS 603981-46-0C₁₆H₂₀N₄O₂S

N-(4-Chlorophenyl)-2-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C16H17ClN4OS, CAS 693234-36-5

N-(4-Chlorophenyl)-2-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]acetamide

CAS 693234-36-5C₁₆H₁₇ClN₄OS

2-[(4-Allyl-5-cyclopropyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,4-dichlorophenyl)acetamide chemical structure, C16H16Cl2N4OS, CAS 431993-38-3

2-[(4-Allyl-5-cyclopropyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,4-dichlorophenyl)acetamide

CAS 431993-38-3C₁₆H₁₆Cl₂N₄OS

N-(4-Bromophenyl)-2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C15H17BrN4OS, CAS 573693-95-5

N-(4-Bromophenyl)-2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide

CAS 573693-95-5C₁₅H₁₇BrN₄OS

N-(4-Bromophenyl)-2-{[5-cyclopropyl-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H17BrN4OS, CAS 578000-83-6

N-(4-Bromophenyl)-2-{[5-cyclopropyl-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide

CAS 578000-83-6C₁₆H₁₇BrN₄OS

2-[(5-Cyclopropyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,4-dichlorophenyl)acetamide chemical structure, C15H16Cl2N4OS, CAS 432499-17-7

2-[(5-Cyclopropyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(3,4-dichlorophenyl)acetamide

CAS 432499-17-7C₁₅H₁₆Cl₂N₄OS

2-[(5-Cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-phenylacetamide chemical structure, C15H18N4OS, CAS 586987-02-2

2-[(5-Cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-phenylacetamide

CAS 586987-02-2C₁₅H₁₈N₄OS

N-(3-Chloro-2-methylphenyl)-2-[(5-cyclopropyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C16H19ClN4OS, CAS 626213-99-8

N-(3-Chloro-2-methylphenyl)-2-[(5-cyclopropyl-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide

CAS 626213-99-8C₁₆H₁₉ClN₄OS

2-[(4-Amino-5-cyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-bromophenyl)acetamide chemical structure, C13H14BrN5OS, CAS 731820-82-9

2-[(4-Amino-5-cyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-bromophenyl)acetamide

CAS 731820-82-9C₁₃H₁₄BrN₅OS

2-[(5-Cyclopropyl-4-propyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-methoxyphenyl)acetamide chemical structure, C17H22N4O2S, CAS 888648-51-9

2-[(5-Cyclopropyl-4-propyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-methoxyphenyl)acetamide

CAS 888648-51-9C₁₇H₂₂N₄O₂S

2-[[5-Cyclopropyl-4-(2-propen-1-yl)-4H-1,2,4-triazol-3-yl]thio]-N-(4-fluorophenyl)acetamide chemical structure, C16H17FN4OS, CAS 891450-23-0

2-[[5-Cyclopropyl-4-(2-propen-1-yl)-4H-1,2,4-triazol-3-yl]thio]-N-(4-fluorophenyl)acetamide

CAS 891450-23-0C₁₆H₁₇FN₄OS

N-(Cyanomethyl)-2-{[5-cyclopropyl-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-phenylacetamide chemical structure, C18H19N5OS, CAS 1037985-84-4

N-(Cyanomethyl)-2-{[5-cyclopropyl-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-phenylacetamide

CAS 1037985-84-4C₁₈H₁₉N₅OS