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Murcko scaffold

Ring system with 2 rings and 13 atoms

22 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
22
With full pages
7
Scaffold SMILES

C(=Cc1nncs1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1nncs1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

1,3,4-Thiadiazol-2-amine, 5-(2-phenylethenyl)- chemical structure, C10H9N3S, CAS 28004-54-8
1,3,4-Thiadiazol-2-amine, 5-(2-phenylethenyl)-
CAS 28004-54-8C10H9N3S
5-Styryl-[1,3,4]thiadiazol-2-ylamine chemical structure, C10H9N3S, CAS 1049978-62-2
5-Styryl-[1,3,4]thiadiazol-2-ylamine
CAS 1049978-62-2C10H9N3S
5-[(E)-2-(2-Chlorophenyl)ethenyl]-1,3,4-thiadiazol-2-amine chemical structure, C10H8ClN3S, CAS 6039-83-4
5-[(E)-2-(2-Chlorophenyl)ethenyl]-1,3,4-thiadiazol-2-amine
CAS 6039-83-4C10H8ClN3S
2-(5-Amino-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)acrylonitrile chemical structure, C12H10N4OS, CAS 170802-09-2
2-(5-Amino-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)acrylonitrile
CAS 170802-09-2C12H10N4OS
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide chemical structure, C16H19N3O2S, CAS 714246-76-1
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethylpropanamide
CAS 714246-76-1C16H19N3O2S
(E)-2-(5-Amino-1,3,4-thiadiazol-2-yl)-3-(2,4-dichlorophenyl)prop-2-enenitrile chemical structure, C11H6Cl2N4S, CAS 338775-21-6
(E)-2-(5-Amino-1,3,4-thiadiazol-2-yl)-3-(2,4-dichlorophenyl)prop-2-enenitrile
CAS 338775-21-6C11H6Cl2N4S
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-2-methylpropanamide chemical structure, C15H17N3O2S, CAS 713092-49-0
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-2-methylpropanamide
CAS 713092-49-0C15H17N3O2S
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]propanamide chemical structure, C14H15N3O2S, CAS 714227-99-3
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]propanamide
CAS 714227-99-3C14H15N3O2S
2-(5-Amino-1,3,4-thiadiazol-2-yl)-3-(2-fluorophenyl)acrylonitrile chemical structure, C11H7FN4S, CAS 338959-97-0
2-(5-Amino-1,3,4-thiadiazol-2-yl)-3-(2-fluorophenyl)acrylonitrile
CAS 338959-97-0C11H7FN4S
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]butanamide chemical structure, C15H17N3O2S, CAS 714292-03-2
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]butanamide
CAS 714292-03-2C15H17N3O2S
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]acetamide chemical structure, C13H13N3O2S, CAS 861638-80-4
N-[5-[(E)-2-(4-Methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]acetamide
CAS 861638-80-4C13H13N3O2S
2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-(5-methyl-1,3,4-thiadiazol-2-yl)ethenyl)phenoxy)- chemical structure, C17H23N3O2S, CAS 72578-09-7
2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-(5-methyl-1,3,4-thiadiazol-2-yl)ethenyl)phenoxy)-
CAS 72578-09-7C17H23N3O2S
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-(2-(2-(5-methyl-1,3,4-thiadiazol-2-yl)ethenyl)phenoxy)- chemical structure, C18H25N3O2S, CAS 72578-10-0
2-Propanol, 1-((1,1-dimethylethyl)amino)-3-(2-(2-(5-methyl-1,3,4-thiadiazol-2-yl)ethenyl)phenoxy)-
CAS 72578-10-0C18H25N3O2S
2-Propanol, 1-((1-methyl-2-propynyl)amino)-3-(2-(2-(5-methyl-1,3,4-thiadiazol-2-yl)ethenyl)phenoxy)- chemical structure, C18H21N3O2S, CAS 72578-11-1
2-Propanol, 1-((1-methyl-2-propynyl)amino)-3-(2-(2-(5-methyl-1,3,4-thiadiazol-2-yl)ethenyl)phenoxy)-
CAS 72578-11-1C18H21N3O2S
N'-{5-[1-Cyano-2-(4-methoxyphenyl)vinyl]-1,3,4-thiadiazol-2-yl}-N,N-dimethyliminoformamide chemical structure, C15H15N5OS, CAS 338775-59-0
N'-{5-[1-Cyano-2-(4-methoxyphenyl)vinyl]-1,3,4-thiadiazol-2-yl}-N,N-dimethyliminoformamide
CAS 338775-59-0C15H15N5OS
N'-{5-[1-Cyano-2-(2,4-dichlorophenyl)vinyl]-1,3,4-thiadiazol-2-yl}-N,N-dimethyliminoformamide chemical structure, C14H11Cl2N5S, CAS 338775-23-8
N'-{5-[1-Cyano-2-(2,4-dichlorophenyl)vinyl]-1,3,4-thiadiazol-2-yl}-N,N-dimethyliminoformamide
CAS 338775-23-8C14H11Cl2N5S
1,3,4-Thiadiazole, 2-amino-5-styryl-, hydrochloride, hydrate chemical structure, C10H12ClN3OS, CAS 102367-69-1
1,3,4-Thiadiazole, 2-amino-5-styryl-, hydrochloride, hydrate
CAS 102367-69-1C10H12ClN3OS
N'-[5-[(E)-1-Cyano-2-(2,4-dichlorophenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-N-methoxymethanimidamide chemical structure, C13H9Cl2N5OS, CAS 338775-34-1
N'-[5-[(E)-1-Cyano-2-(2,4-dichlorophenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-N-methoxymethanimidamide
CAS 338775-34-1C13H9Cl2N5OS
N'-[5-[(E)-1-Cyano-2-(4-methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-N-methoxymethanimidamide chemical structure, C14H13N5O2S, CAS 338775-61-4
N'-[5-[(E)-1-Cyano-2-(4-methoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-yl]-N-methoxymethanimidamide
CAS 338775-61-4C14H13N5O2S
2-Methyl-5-(2-phenylethenyl)-1,3,4-thiadiazole chemical structure, C11H10N2S, CAS 75341-25-2
2-Methyl-5-(2-phenylethenyl)-1,3,4-thiadiazole
CAS 75341-25-2C11H10N2S
5-[2-(4-Fluorophenyl)ethenyl]-1,3,4-thiadiazol-2-amine chemical structure, C10H8FN3S, CAS 88742-99-8
5-[2-(4-Fluorophenyl)ethenyl]-1,3,4-thiadiazol-2-amine
CAS 88742-99-8C10H8FN3S
5-[2-(3,4,5-Trimethoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-amine chemical structure, C13H15N3O3S, CAS 88743-00-4
5-[2-(3,4,5-Trimethoxyphenyl)ethenyl]-1,3,4-thiadiazol-2-amine
CAS 88743-00-4C13H15N3O3S