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Murcko scaffold

3-(4-Benzylpiperazin-1-yl)-1-phenylpyrrolidine-2,5-dione scaffold

38 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
38
With full pages
8
Scaffold SMILES

O=C1CC(N2CCN(Cc3ccccc3)CC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(4-Benzylpiperazin-1-yl)-1-phenylpyrrolidine-2,5-dione page
Murcko scaffold O=C1CC(N2CCN(Cc3ccccc3)CC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

3-(4-Benzylpiperazin-1-yl)-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C22H25N3O3, CAS 299408-79-0
3-(4-Benzylpiperazin-1-yl)-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 299408-79-0C22H25N3O3
3-(4-Benzyl-piperazin-1-yl)-1-m-tolyl-pyrrolidine-2,5-dione chemical structure, C22H25N3O2, CAS 299408-51-8
3-(4-Benzyl-piperazin-1-yl)-1-m-tolyl-pyrrolidine-2,5-dione
CAS 299408-51-8C22H25N3O2
3-(4-Benzylpiperazin-1-yl)-1-(3-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C21H22ClN3O2, CAS 299408-52-9
3-(4-Benzylpiperazin-1-yl)-1-(3-chlorophenyl)pyrrolidine-2,5-dione
CAS 299408-52-9C21H22ClN3O2
3-(4-Benzylpiperazin-1-yl)-1-(4-bromophenyl)pyrrolidine-2,5-dione chemical structure, C21H22BrN3O2, CAS 299408-53-0
3-(4-Benzylpiperazin-1-yl)-1-(4-bromophenyl)pyrrolidine-2,5-dione
CAS 299408-53-0C21H22BrN3O2
3-(4-Benzylpiperazin-1-yl)-1-(2-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C22H25N3O3, CAS 299408-83-6
3-(4-Benzylpiperazin-1-yl)-1-(2-methoxyphenyl)pyrrolidine-2,5-dione
CAS 299408-83-6C22H25N3O3
3-(4-Benzylpiperazin-1-yl)-1-phenylpyrrolidine-2,5-dione chemical structure, C21H23N3O2, CAS 299408-70-1
3-(4-Benzylpiperazin-1-yl)-1-phenylpyrrolidine-2,5-dione
CAS 299408-70-1C21H23N3O2
3-(4-Benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C23H27N3O3, CAS 21621-48-7
3-(4-Benzylpiperazin-1-yl)-1-(4-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 21621-48-7C23H27N3O3
3-(4-Benzylpiperazin-1-yl)-1-(3-bromophenyl)pyrrolidine-2,5-dione chemical structure, C21H22BrN3O2, CAS 300730-44-3
3-(4-Benzylpiperazin-1-yl)-1-(3-bromophenyl)pyrrolidine-2,5-dione
CAS 300730-44-3C21H22BrN3O2
4-[3-(4-Benzylpiperazin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoic acid chemical structure, C22H23N3O4, CAS 313378-48-2
4-[3-(4-Benzylpiperazin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoic acid
CAS 313378-48-2C22H23N3O4
3-(4-Benzylpiperazin-1-yl)-1-[4-(hexyloxy)phenyl]pyrrolidine-2,5-dione chemical structure, C27H35N3O3, CAS 312272-74-5
3-(4-Benzylpiperazin-1-yl)-1-[4-(hexyloxy)phenyl]pyrrolidine-2,5-dione
CAS 312272-74-5C27H35N3O3
3-(4-Benzylpiperazin-1-yl)-1-(4-propoxyphenyl)pyrrolidine-2,5-dione chemical structure, C24H29N3O3, CAS 5560-02-1
3-(4-Benzylpiperazin-1-yl)-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 5560-02-1C24H29N3O3
3-(4-Benzylpiperazin-1-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C21H22FN3O2, CAS 313378-52-8
3-(4-Benzylpiperazin-1-yl)-1-(4-fluorophenyl)pyrrolidine-2,5-dione
CAS 313378-52-8C21H22FN3O2
3-(4-Benzylpiperazin-1-yl)-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C23H27N3O3, CAS 332052-90-1
3-(4-Benzylpiperazin-1-yl)-1-(3-ethoxyphenyl)pyrrolidine-2,5-dione
CAS 332052-90-1C23H27N3O3
Methyl 4-[3-(4-benzylpiperazin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C23H25N3O4, CAS 313380-82-4
Methyl 4-[3-(4-benzylpiperazin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 313380-82-4C23H25N3O4
3-(4-Benzylpiperazin-1-yl)-1-(2-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C21H22FN3O2, CAS 330865-53-7
3-(4-Benzylpiperazin-1-yl)-1-(2-fluorophenyl)pyrrolidine-2,5-dione
CAS 330865-53-7C21H22FN3O2
3-(4-Benzylpiperazin-1-yl)-1-(4-butoxyphenyl)pyrrolidine-2,5-dione chemical structure, C25H31N3O3, CAS 312504-80-6
3-(4-Benzylpiperazin-1-yl)-1-(4-butoxyphenyl)pyrrolidine-2,5-dione
CAS 312504-80-6C25H31N3O3
3-(4-Benzylpiperazin-1-yl)-1-(4-iodophenyl)pyrrolidine-2,5-dione chemical structure, C21H22IN3O2, CAS 311800-75-6
3-(4-Benzylpiperazin-1-yl)-1-(4-iodophenyl)pyrrolidine-2,5-dione
CAS 311800-75-6C21H22IN3O2
3-(4-Benzylpiperazin-1-yl)-1-(3-chloro-4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C22H24ClN3O2, CAS 5932-23-0
3-(4-Benzylpiperazin-1-yl)-1-(3-chloro-4-methylphenyl)pyrrolidine-2,5-dione
CAS 5932-23-0C22H24ClN3O2
Ethyl 4-[3-(4-benzylpiperazin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C24H27N3O4, CAS 330865-07-1
Ethyl 4-[3-(4-benzylpiperazin-1-yl)-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 330865-07-1C24H27N3O4
3-(4-Benzylpiperazin-1-yl)-1-(4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C22H25N3O2, CAS 354786-18-8
3-(4-Benzylpiperazin-1-yl)-1-(4-methylphenyl)pyrrolidine-2,5-dione
CAS 354786-18-8C22H25N3O2
3-(4-Benzylpiperazin-1-yl)-1-(2,5-dimethoxyphenyl)pyrrolidine-2,5-dione chemical structure, C23H27N3O4, CAS 511515-28-9
3-(4-Benzylpiperazin-1-yl)-1-(2,5-dimethoxyphenyl)pyrrolidine-2,5-dione
CAS 511515-28-9C23H27N3O4
3-(4-Benzylpiperazin-1-yl)-1-(2-chloro-4-methylphenyl)pyrrolidine-2,5-dione chemical structure, C22H24ClN3O2, CAS 511515-26-7
3-(4-Benzylpiperazin-1-yl)-1-(2-chloro-4-methylphenyl)pyrrolidine-2,5-dione
CAS 511515-26-7C22H24ClN3O2
Ethyl 4-[3-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl]benzoate chemical structure, C24H26ClN3O4, CAS 522649-63-4
Ethyl 4-[3-[4-[(2-chlorophenyl)methyl]piperazin-1-yl]-2,5-dioxopyrrolidin-1-yl]benzoate
CAS 522649-63-4C24H26ClN3O4
3-[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-1-(3-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C22H24ClN3O3, CAS 522649-66-7
3-[4-[(2-Chlorophenyl)methyl]piperazin-1-yl]-1-(3-methoxyphenyl)pyrrolidine-2,5-dione
CAS 522649-66-7C22H24ClN3O3