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Murcko scaffold

1-Phenyl-3-[4-(phenylsulfonyl)-1-piperazinyl]-2,5-pyrrolidinedione scaffold

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
11
With full pages
6
Scaffold SMILES

O=C1CC(N2CCN(S(=O)(=O)c3ccccc3)CC2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-3-[4-(phenylsulfonyl)-1-piperazinyl]-2,5-pyrrolidinedione page
Murcko scaffold O=C1CC(N2CCN(S(=O)(=O)c3ccccc3)CC2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

3-[4-(Benzenesulfonyl)piperazin-1-yl]-1-(4-bromophenyl)pyrrolidine-2,5-dione chemical structure, C20H20BrN3O4S, CAS 301654-62-6
3-[4-(Benzenesulfonyl)piperazin-1-yl]-1-(4-bromophenyl)pyrrolidine-2,5-dione
CAS 301654-62-6C20H20BrN3O4S
1-(3,5-Dichlorophenyl)-3-[4-(phenylsulfonyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H19Cl2N3O4S, CAS 333398-93-9
1-(3,5-Dichlorophenyl)-3-[4-(phenylsulfonyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 333398-93-9C20H19Cl2N3O4S
1-(2,4-Dimethylphenyl)-3-[4-(phenylsulfonyl)piperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C22H25N3O4S, CAS 311766-63-9
1-(2,4-Dimethylphenyl)-3-[4-(phenylsulfonyl)piperazin-1-yl]pyrrolidine-2,5-dione
CAS 311766-63-9C22H25N3O4S
1-Phenyl-3-[4-(phenylsulfonyl)-1-piperazinyl]-2,5-pyrrolidinedione chemical structure, C20H21N3O4S, CAS 293766-07-1
1-Phenyl-3-[4-(phenylsulfonyl)-1-piperazinyl]-2,5-pyrrolidinedione
CAS 293766-07-1C20H21N3O4S
3-[4-(Benzenesulfonyl)piperazin-1-yl]-1-(3-chlorophenyl)pyrrolidine-2,5-dione chemical structure, C20H20ClN3O4S, CAS 293765-98-7
3-[4-(Benzenesulfonyl)piperazin-1-yl]-1-(3-chlorophenyl)pyrrolidine-2,5-dione
CAS 293765-98-7C20H20ClN3O4S
1-(2-Chlorophenyl)-3-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C23H26ClN3O4S, CAS 852307-42-7
1-(2-Chlorophenyl)-3-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione
CAS 852307-42-7C23H26ClN3O4S
3-[4-(3,4-Dimethylphenyl)sulfonylpiperazin-1-yl]-1-(4-fluorophenyl)pyrrolidine-2,5-dione chemical structure, C22H24FN3O4S, CAS 852939-96-9
3-[4-(3,4-Dimethylphenyl)sulfonylpiperazin-1-yl]-1-(4-fluorophenyl)pyrrolidine-2,5-dione
CAS 852939-96-9C22H24FN3O4S
1-(4-Acetylphenyl)-3-[4-(2,5-dimethylphenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C24H27N3O5S, CAS 851209-35-3
1-(4-Acetylphenyl)-3-[4-(2,5-dimethylphenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione
CAS 851209-35-3C24H27N3O5S
1-(5-Chloro-2-methoxyphenyl)-3-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C21H21ClFN3O5S, CAS 850023-59-5
1-(5-Chloro-2-methoxyphenyl)-3-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione
CAS 850023-59-5C21H21ClFN3O5S
1-(2,6-Dimethylphenyl)-3-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C22H24FN3O4S, CAS 749876-14-0
1-(2,6-Dimethylphenyl)-3-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione
CAS 749876-14-0C22H24FN3O4S
1-(4-Chlorophenyl)-3-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione chemical structure, C20H19ClFN3O4S, CAS 5550-01-6
1-(4-Chlorophenyl)-3-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]pyrrolidine-2,5-dione
CAS 5550-01-6C20H19ClFN3O4S