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Murcko scaffold

Ring system with 4 rings and 25 atoms

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
23
With full pages
2
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2nc(-c3ccccc3)cs2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(c2nc(-c3ccccc3)cs2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

4-[2-(4-Benzoyl-1-piperazinyl)-1,3-thiazol-4-yl]phenyl methyl ether chemical structure, C21H21N3O2S, CAS 302905-01-7
4-[2-(4-Benzoyl-1-piperazinyl)-1,3-thiazol-4-yl]phenyl methyl ether
CAS 302905-01-7C21H21N3O2S
(3,4-Dichlorophenyl)-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone chemical structure, C20H17Cl2N3OS, CAS 695198-30-2
(3,4-Dichlorophenyl)-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone
CAS 695198-30-2C20H17Cl2N3OS
1-Benzoyl-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine chemical structure, C20H18FN3OS, CAS 837385-24-7
1-Benzoyl-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]piperazine
CAS 837385-24-7C20H18FN3OS
[4-(4-Phenylthiazol-2-yl)-piperazin-1-yl]-p-tolylmethanone chemical structure, C21H21N3OS, CAS 606087-50-7
[4-(4-Phenylthiazol-2-yl)-piperazin-1-yl]-p-tolylmethanone
CAS 606087-50-7C21H21N3OS
(2-Fluorophenyl)-[4-(4-phenylthiazol-2-yl)-piperazin-1-yl]methanone chemical structure, C20H18FN3OS, CAS 606087-51-8
(2-Fluorophenyl)-[4-(4-phenylthiazol-2-yl)-piperazin-1-yl]methanone
CAS 606087-51-8C20H18FN3OS
(4-Fluorophenyl)-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone chemical structure, C20H18FN3OS, CAS 606087-52-9
(4-Fluorophenyl)-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone
CAS 606087-52-9C20H18FN3OS
(4-Chlorophenyl)-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone chemical structure, C20H18ClN3OS, CAS 606087-53-0
(4-Chlorophenyl)-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone
CAS 606087-53-0C20H18ClN3OS
[4-(4-Phenylthiazol-2-yl)piperazin-1-yl](O-tolyl)methanone chemical structure, C21H21N3OS, CAS 606087-59-6
[4-(4-Phenylthiazol-2-yl)piperazin-1-yl](O-tolyl)methanone
CAS 606087-59-6C21H21N3OS
(3-Fluorophenyl)[4-(4-phenyl-1,3-thiazol-2-yl)-1-piperazinyl]methanone chemical structure, C20H18FN3OS, CAS 606087-60-9
(3-Fluorophenyl)[4-(4-phenyl-1,3-thiazol-2-yl)-1-piperazinyl]methanone
CAS 606087-60-9C20H18FN3OS
(2-Nitrophenyl)-[4-(4-phenylthiazol-2-yl)-piperazin-1-yl]methanone chemical structure, C20H18N4O3S, CAS 606087-62-1
(2-Nitrophenyl)-[4-(4-phenylthiazol-2-yl)-piperazin-1-yl]methanone
CAS 606087-62-1C20H18N4O3S
(3-Nitrophenyl)-[4-(4-phenylthiazol-2-yl)-piperazin-1-yl]methanone chemical structure, C20H18N4O3S, CAS 606087-63-2
(3-Nitrophenyl)-[4-(4-phenylthiazol-2-yl)-piperazin-1-yl]methanone
CAS 606087-63-2C20H18N4O3S
(4-Nitrophenyl)[4-(4-phenyl-1,3-thiazol-2-yl)-1-piperazinyl]methanone chemical structure, C20H18N4O3S, CAS 606087-64-3
(4-Nitrophenyl)[4-(4-phenyl-1,3-thiazol-2-yl)-1-piperazinyl]methanone
CAS 606087-64-3C20H18N4O3S
Piperazine, 1-(2,4-difluorobenzoyl)-4-(4-phenyl-2-thiazolyl)- chemical structure, C20H17F2N3OS, CAS 606087-69-8
Piperazine, 1-(2,4-difluorobenzoyl)-4-(4-phenyl-2-thiazolyl)-
CAS 606087-69-8C20H17F2N3OS
(3,4-Difluorophenyl)[4-(4-phenyl-1,3-thiazol-2-yl)-1-piperazinyl]methanone chemical structure, C20H17F2N3OS, CAS 606087-70-1
(3,4-Difluorophenyl)[4-(4-phenyl-1,3-thiazol-2-yl)-1-piperazinyl]methanone
CAS 606087-70-1C20H17F2N3OS
(2-Fluorophenyl){4-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]-1-piperazinyl}methanone chemical structure, C21H20FN3O2S, CAS 606087-87-0
(2-Fluorophenyl){4-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]-1-piperazinyl}methanone
CAS 606087-87-0C21H20FN3O2S
(4-Fluorophenyl){4-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]-1-piperazinyl}methanone chemical structure, C21H20FN3O2S, CAS 606087-88-1
(4-Fluorophenyl){4-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]-1-piperazinyl}methanone
CAS 606087-88-1C21H20FN3O2S
[4-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]piperazin-1-yl]-(2-methylphenyl)methanone chemical structure, C22H23N3O2S, CAS 606088-60-2
[4-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]piperazin-1-yl]-(2-methylphenyl)methanone
CAS 606088-60-2C22H23N3O2S
Piperazine, 1-(3-fluorobenzoyl)-4-[4-(3-methoxyphenyl)-2-thiazolyl]- chemical structure, C21H20FN3O2S, CAS 606088-62-4
Piperazine, 1-(3-fluorobenzoyl)-4-[4-(3-methoxyphenyl)-2-thiazolyl]-
CAS 606088-62-4C21H20FN3O2S
Phenyl-[4-(4-phenyl-5-propyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone chemical structure, C23H25N3OS, CAS 345990-21-8
Phenyl-[4-(4-phenyl-5-propyl-1,3-thiazol-2-yl)piperazin-1-yl]methanone
CAS 345990-21-8C23H25N3OS
[4-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]piperazin-1-yl]-phenylmethanone chemical structure, C20H18ClN3OS, CAS 309266-51-1
[4-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]piperazin-1-yl]-phenylmethanone
CAS 309266-51-1C20H18ClN3OS
[4-[4-(4-Nitrophenyl)-1,3-thiazol-2-yl]piperazin-1-yl]-phenylmethanone chemical structure, C20H18N4O3S, CAS 346596-73-4
[4-[4-(4-Nitrophenyl)-1,3-thiazol-2-yl]piperazin-1-yl]-phenylmethanone
CAS 346596-73-4C20H18N4O3S
1-Benzoyl-4-[4-(4-methylphenyl)-1,3-thiazol-2-yl]piperazine chemical structure, C21H21N3OS, CAS 925611-73-0
1-Benzoyl-4-[4-(4-methylphenyl)-1,3-thiazol-2-yl]piperazine
CAS 925611-73-0C21H21N3OS
(4-Chlorophenyl){4-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-1-piperazinyl}methanone chemical structure, C21H20ClN3OS, CAS 606087-71-2
(4-Chlorophenyl){4-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-1-piperazinyl}methanone
CAS 606087-71-2C21H20ClN3OS