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Murcko scaffold

Ring system with 4 rings and 24 atoms

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
13
With full pages
3
Scaffold SMILES

c1ccc(Oc2ccc(-c3ccn(C4CCCNC4)n3)cc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Oc2ccc(-c3ccn(C4CCCNC4)n3)cc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

5-Amino-3-[4-(4-chlorophenoxy)phenyl]-1-[(3R)-1-cyanopiperidin-3-yl]pyrazole-4-carboxamide chemical structure, C22H21ClN6O2, CAS 1609465-78-2
5-Amino-3-[4-(4-chlorophenoxy)phenyl]-1-[(3R)-1-cyanopiperidin-3-yl]pyrazole-4-carboxamide
CAS 1609465-78-2C22H21ClN6O2
5-Amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide chemical structure, C22H20F2N6O2, CAS 1609286-06-7
5-Amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide
CAS 1609286-06-7C22H20F2N6O2
Btk inhibitor 2 chemical structure, C24H25N5O3, CAS 1558036-85-3
Btk inhibitor 2
CAS 1558036-85-3C24H25N5O3
5-Amino-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide chemical structure, C21H23N5O2, CAS 1609467-45-9
5-Amino-3-(4-phenoxyphenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide
CAS 1609467-45-9C21H23N5O2
(R)-5-Amino-3-(4-(2,4-difluorophenoxy)phenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide chemical structure, C21H21F2N5O2, CAS 1609468-26-9
(R)-5-Amino-3-(4-(2,4-difluorophenoxy)phenyl)-1-(piperidin-3-yl)-1H-pyrazole-4-carboxamide
CAS 1609468-26-9C21H21F2N5O2
5-Amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide chemical structure, C22H20F2N6O2, CAS 1609465-89-5
5-Amino-1-[(3S)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]pyrazole-4-carboxamide
CAS 1609465-89-5C22H20F2N6O2
5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazole-4-carboxamide chemical structure, C22H20F2N6O2, CAS 1609465-88-4
5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-(2,4-difluorophenoxy)phenyl)-1H-pyrazole-4-carboxamide
CAS 1609465-88-4C22H20F2N6O2
tert-Butyl 3-[5-amino-4-cyano-3-(4-phenoxyphenyl)pyrazol-1-yl]piperidine-1-carboxylate chemical structure, C26H29N5O3, CAS 1612774-47-6
tert-Butyl 3-[5-amino-4-cyano-3-(4-phenoxyphenyl)pyrazol-1-yl]piperidine-1-carboxylate
CAS 1612774-47-6C26H29N5O3
(R)-tert-Butyl 3-(5-amino-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate chemical structure, C26H29N5O3, CAS 1612774-50-1
(R)-tert-Butyl 3-(5-amino-4-cyano-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS 1612774-50-1C26H29N5O3
tert-Butyl 3-(5-amino-4-carbamoyl-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate chemical structure, C26H31N5O4, CAS 1643530-93-1
tert-Butyl 3-(5-amino-4-carbamoyl-3-(4-phenoxyphenyl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS 1643530-93-1C26H31N5O4
5-Amino-3-(4-phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazole-4-carbonitrile chemical structure, C21H21N5O, CAS 1609467-44-8
5-Amino-3-(4-phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazole-4-carbonitrile
CAS 1609467-44-8C21H21N5O
1H-Pyrazole-4-carbonitrile, 5-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)- chemical structure, C24H23N5O2, CAS 1574506-72-1
1H-Pyrazole-4-carbonitrile, 5-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-
CAS 1574506-72-1C24H23N5O2
Orb3136767 chemical structure, C34H44F2N8O9, CAS 2250382-80-8
Orb3136767
CAS 2250382-80-8C34H44F2N8O9