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Murcko scaffold

Piperazine, 1-(3,4-methylenedioxybenzyl)-4-(2-pyridyl)- scaffold

10 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
10
With full pages
2
Scaffold SMILES

c1ccc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)nc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine, 1-(3,4-methylenedioxybenzyl)-4-(2-pyridyl)- page
Murcko scaffold c1ccc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)nc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

Piperazine, 1-(3,4-methylenedioxybenzyl)-4-(2-pyridyl)- chemical structure, C17H19N3O2, CAS 59215-20-2
Piperazine, 1-(3,4-methylenedioxybenzyl)-4-(2-pyridyl)-
CAS 59215-20-2C17H19N3O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(5-nitropyridin-2-yl)piperazine chemical structure, C17H18N4O4, CAS 419542-59-9
1-(1,3-Benzodioxol-5-ylmethyl)-4-(5-nitropyridin-2-yl)piperazine
CAS 419542-59-9C17H18N4O4
Piperazine, 2,6-dimethyl-1-(3,4-(methylenedioxy)benzyl)-4-(2-pyridyl)-, hydrochloride, (Z)- chemical structure, C19H24ClN3O2, CAS 102233-09-0
Piperazine, 2,6-dimethyl-1-(3,4-(methylenedioxy)benzyl)-4-(2-pyridyl)-, hydrochloride, (Z)-
CAS 102233-09-0C19H24ClN3O2
2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-3-pyridinamine chemical structure, C17H20N4O2, CAS 1082042-75-8
2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]-3-pyridinamine
CAS 1082042-75-8C17H20N4O2
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(3-fluoropyridin-2-yl)piperazine chemical structure, C17H18FN3O2, CAS 2785135-92-2
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(3-fluoropyridin-2-yl)piperazine
CAS 2785135-92-2C17H18FN3O2
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(3-bromopyridin-2-yl)piperazine chemical structure, C17H18BrN3O2, CAS 2783413-96-5
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(3-bromopyridin-2-yl)piperazine
CAS 2783413-96-5C17H18BrN3O2
2-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-5-bromopyridine-3-carbonitrile chemical structure, C18H17BrN4O2, CAS 3054630-46-2
2-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-5-bromopyridine-3-carbonitrile
CAS 3054630-46-2C18H17BrN4O2
2-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-6-methylpyridine-3-carbonitrile chemical structure, C19H20N4O2, CAS 3054555-43-7
2-{4-[(2H-1,3-Benzodioxol-5-yl)methyl]piperazin-1-yl}-6-methylpyridine-3-carbonitrile
CAS 3054555-43-7C19H20N4O2
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3-chloropyridin-2-yl)piperazine chemical structure, C17H18ClN3O2, CAS 2327451-59-0
1-(1,3-Benzodioxol-5-ylmethyl)-4-(3-chloropyridin-2-yl)piperazine
CAS 2327451-59-0C17H18ClN3O2
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(5-chloro-3-fluoropyridin-2-yl)piperazine chemical structure, C17H17ClFN3O2, CAS 3054550-86-3
1-[(2H-1,3-Benzodioxol-5-yl)methyl]-4-(5-chloro-3-fluoropyridin-2-yl)piperazine
CAS 3054550-86-3C17H17ClFN3O2