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Murcko scaffold

1-((2H-1,3-Benzodioxol-5-yl)methyl)-4-phenylpiperazine scaffold

56 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
56
With full pages
9
Scaffold SMILES

c1ccc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-((2H-1,3-Benzodioxol-5-yl)methyl)-4-phenylpiperazine page
Murcko scaffold c1ccc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 56 chemicals

1-((2H-1,3-Benzodioxol-5-yl)methyl)-4-phenylpiperazine chemical structure, C18H20N2O2, CAS 67361-21-1
1-((2H-1,3-Benzodioxol-5-yl)methyl)-4-phenylpiperazine
CAS 67361-21-1C18H20N2O2
1-[(7-Methoxy-2H-1,3-benzodioxol-5-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C20H21F3N2O3, CAS 5345-91-5
1-[(7-Methoxy-2H-1,3-benzodioxol-5-yl)methyl]-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 5345-91-5C20H21F3N2O3
6-[[4-(4-Fluorophenyl)piperazin-1-yl]methyl]-1,3-benzodioxol-5-ol chemical structure, C18H19FN2O3, CAS 735305-78-9
6-[[4-(4-Fluorophenyl)piperazin-1-yl]methyl]-1,3-benzodioxol-5-ol
CAS 735305-78-9C18H19FN2O3
6-[(4-Phenylpiperazin-1-yl)methyl]-1,3-benzodioxol-5-ol chemical structure, C18H20N2O3, CAS 878929-81-8
6-[(4-Phenylpiperazin-1-yl)methyl]-1,3-benzodioxol-5-ol
CAS 878929-81-8C18H20N2O3
1-(2,3-Dimethylphenyl)-4-[(6-nitro-1,3-benzodioxol-5-yl)methyl]piperazine chemical structure, C20H23N3O4, CAS 414875-19-7
1-(2,3-Dimethylphenyl)-4-[(6-nitro-1,3-benzodioxol-5-yl)methyl]piperazine
CAS 414875-19-7C20H23N3O4
Piperazine, 1-(1,3-benzodioxol-5-ylmethyl)-2,2,6-trimethyl-4-phenyl-, (S)- chemical structure, C21H26N2O2, CAS 62733-60-2
Piperazine, 1-(1,3-benzodioxol-5-ylmethyl)-2,2,6-trimethyl-4-phenyl-, (S)-
CAS 62733-60-2C21H26N2O2
4-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-3-nitrobenzenecarboxylic acid chemical structure, C19H19N3O6, CAS 478246-64-9
4-[4-(1,3-Benzodioxol-5-ylmethyl)piperazino]-3-nitrobenzenecarboxylic acid
CAS 478246-64-9C19H19N3O6
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-5-nitrobenzaldehyde chemical structure, C19H19N3O5, CAS 900260-84-6
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-5-nitrobenzaldehyde
CAS 900260-84-6C19H19N3O5
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-5-nitrobenzonitrile chemical structure, C19H18N4O4, CAS 924072-98-0
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-5-nitrobenzonitrile
CAS 924072-98-0C19H18N4O4
N-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl)-3,3-dimethylbutanamide chemical structure, C25H33N3O3, CAS 896348-12-2
N-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl)-3,3-dimethylbutanamide
CAS 896348-12-2C25H33N3O3
2-(2H-Benzo[3,4-d]1,3-dioxolen-5-yl)-2-[4-(4-fluorophenyl)piperazinyl]ethylami ne chemical structure, C19H22FN3O2, CAS 887345-62-2
2-(2H-Benzo[3,4-d]1,3-dioxolen-5-yl)-2-[4-(4-fluorophenyl)piperazinyl]ethylami ne
CAS 887345-62-2C19H22FN3O2
N-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)acetamide chemical structure, C22H27N3O4, CAS 896359-61-8
N-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)acetamide
CAS 896359-61-8C22H27N3O4
Methyl (2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)carbamate chemical structure, C22H27N3O5, CAS 896359-88-9
Methyl (2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)carbamate
CAS 896359-88-9C22H27N3O5
N-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)isobutyramide chemical structure, C24H31N3O4, CAS 896359-94-7
N-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)isobutyramide
CAS 896359-94-7C24H31N3O4
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-(2-hydroxyethyl)oxalamide chemical structure, C23H27FN4O5, CAS 896360-99-9
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-(2-hydroxyethyl)oxalamide
CAS 896360-99-9C23H27FN4O5
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-(3-hydroxypropyl)oxalamide chemical structure, C24H29FN4O5, CAS 896361-09-4
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-(3-hydroxypropyl)oxalamide
CAS 896361-09-4C24H29FN4O5
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(2-fluorophenyl)piperazin-1-yl)ethyl)-N2-(2-hydroxyethyl)oxalamide chemical structure, C23H27FN4O5, CAS 896363-90-9
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(2-fluorophenyl)piperazin-1-yl)ethyl)-N2-(2-hydroxyethyl)oxalamide
CAS 896363-90-9C23H27FN4O5
1-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl)-3-(tert-butyl)urea chemical structure, C24H32N4O3, CAS 896353-60-9
1-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl)-3-(tert-butyl)urea
CAS 896353-60-9C24H32N4O3
Methyl (2-(benzo[d][1,3]dioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl)carbamate chemical structure, C21H25N3O4, CAS 896356-58-4
Methyl (2-(benzo[d][1,3]dioxol-5-yl)-2-(4-phenylpiperazin-1-yl)ethyl)carbamate
CAS 896356-58-4C21H25N3O4
1-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)-3-(tert-butyl)urea chemical structure, C25H34N4O4, CAS 896358-25-1
1-(2-(Benzo[d][1,3]dioxol-5-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)-3-(tert-butyl)urea
CAS 896358-25-1C25H34N4O4
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-propyloxalamide chemical structure, C24H29FN4O4, CAS 896360-41-1
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-propyloxalamide
CAS 896360-41-1C24H29FN4O4
N1-allyl-N2-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)oxalamide chemical structure, C24H27FN4O4, CAS 896360-46-6
N1-allyl-N2-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)oxalamide
CAS 896360-46-6C24H27FN4O4
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-isopentyloxalamide chemical structure, C26H33FN4O4, CAS 896360-52-4
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-isopentyloxalamide
CAS 896360-52-4C26H33FN4O4
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-(2-(dimethylamino)ethyl)oxalamide chemical structure, C25H32FN5O4, CAS 896360-57-9
N1-(2-(benzo[d][1,3]dioxol-5-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethyl)-N2-(2-(dimethylamino)ethyl)oxalamide
CAS 896360-57-9C25H32FN5O4