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Murcko scaffold

1,3-Benzodioxol-5-yl(4-phenylpiperazin-1-yl)methanone scaffold

24 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
24
With full pages
11
Scaffold SMILES

O=C(c1ccc2c(c1)OCO2)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,3-Benzodioxol-5-yl(4-phenylpiperazin-1-yl)methanone page
Murcko scaffold O=C(c1ccc2c(c1)OCO2)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

Benzo[1,3]dioxol-5-yl-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone chemical structure, C18H17FN2O3, CAS 328286-62-0
Benzo[1,3]dioxol-5-yl-[4-(4-fluoro-phenyl)-piperazin-1-yl]-methanone
CAS 328286-62-0C18H17FN2O3
1,3-Benzodioxol-5-yl(4-phenylpiperazin-1-yl)methanone chemical structure, C18H18N2O3, CAS 326907-82-8
1,3-Benzodioxol-5-yl(4-phenylpiperazin-1-yl)methanone
CAS 326907-82-8C18H18N2O3
1,3-Benzodioxol-5-yl[4-(3-chlorophenyl)piperazin-1-yl]methanone chemical structure, C18H17ClN2O3, CAS 314023-25-1
1,3-Benzodioxol-5-yl[4-(3-chlorophenyl)piperazin-1-yl]methanone
CAS 314023-25-1C18H17ClN2O3
1,3-Benzodioxol-5-yl[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H20N2O4, CAS 494825-71-7
1,3-Benzodioxol-5-yl[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 494825-71-7C19H20N2O4
1,3-Benzodioxol-5-yl-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C18H17FN2O3, CAS 547707-02-8
1,3-Benzodioxol-5-yl-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 547707-02-8C18H17FN2O3
1,3-Benzodioxol-5-yl[4-(4-chlorophenyl)piperazin-1-yl]methanone chemical structure, C18H17ClN2O3, CAS 352679-40-4
1,3-Benzodioxol-5-yl[4-(4-chlorophenyl)piperazin-1-yl]methanone
CAS 352679-40-4C18H17ClN2O3
1,3-Benzodioxol-5-yl[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H20N2O4, CAS 333432-72-7
1,3-Benzodioxol-5-yl[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 333432-72-7C19H20N2O4
Benzo[1,3]dioxol-5-yl-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone chemical structure, C19H17F3N2O3, CAS 303135-93-5
Benzo[1,3]dioxol-5-yl-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone
CAS 303135-93-5C19H17F3N2O3
1,3-Benzodioxol-5-yl-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H22N2O4, CAS 314055-83-9
1,3-Benzodioxol-5-yl-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 314055-83-9C20H22N2O4
1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone chemical structure, C20H20N2O4, CAS 774589-47-8
1-(4-(4-(Benzo[d][1,3]dioxole-5-carbonyl)piperazin-1-yl)phenyl)ethanone
CAS 774589-47-8C20H20N2O4
1,3-Benzodioxol-5-yl-[4-(4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C18H17N3O5, CAS 346698-88-2
1,3-Benzodioxol-5-yl-[4-(4-nitrophenyl)piperazin-1-yl]methanone
CAS 346698-88-2C18H17N3O5
1,3-Benzodioxol-5-yl[4-(2-chloro-6-nitrophenyl)piperazin-1-yl]methanone chemical structure, C18H16ClN3O5, CAS 701947-39-9
1,3-Benzodioxol-5-yl[4-(2-chloro-6-nitrophenyl)piperazin-1-yl]methanone
CAS 701947-39-9C18H16ClN3O5
1,3-Benzodioxol-5-yl[4-(4-chloro-2-nitrophenyl)piperazin-1-yl]methanone chemical structure, C18H16ClN3O5, CAS 706769-57-5
1,3-Benzodioxol-5-yl[4-(4-chloro-2-nitrophenyl)piperazin-1-yl]methanone
CAS 706769-57-5C18H16ClN3O5
1,3-Benzodioxol-5-yl-[4-[2-nitro-4-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C19H16F3N3O5, CAS 706774-33-6
1,3-Benzodioxol-5-yl-[4-[2-nitro-4-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 706774-33-6C19H16F3N3O5
1,3-Benzodioxol-5-yl-[4-(4-chloro-2,3,5,6-tetrafluorophenyl)piperazin-1-yl]methanone chemical structure, C18H13ClF4N2O3, CAS 847501-47-7
1,3-Benzodioxol-5-yl-[4-(4-chloro-2,3,5,6-tetrafluorophenyl)piperazin-1-yl]methanone
CAS 847501-47-7C18H13ClF4N2O3
1,3-Benzodioxol-5-yl-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]methanone chemical structure, C19H19ClN2O3, CAS 873587-95-2
1,3-Benzodioxol-5-yl-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]methanone
CAS 873587-95-2C19H19ClN2O3
1,3-Benzodioxol-5-yl-[4-(2,6-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C20H22N2O3, CAS 873587-94-1
1,3-Benzodioxol-5-yl-[4-(2,6-dimethylphenyl)piperazin-1-yl]methanone
CAS 873587-94-1C20H22N2O3
1,3-Benzodioxol-5-yl[4-(4-ethylphenyl)piperazin-1-yl]methanone chemical structure, C20H22N2O3, CAS 873587-93-0
1,3-Benzodioxol-5-yl[4-(4-ethylphenyl)piperazin-1-yl]methanone
CAS 873587-93-0C20H22N2O3
1,3-Benzodioxol-5-yl[4-(2,5-dichlorophenyl)piperazin-1-yl]methanone chemical structure, C18H16Cl2N2O3, CAS 873587-92-9
1,3-Benzodioxol-5-yl[4-(2,5-dichlorophenyl)piperazin-1-yl]methanone
CAS 873587-92-9C18H16Cl2N2O3
1,3-Benzodioxol-5-yl-[4-(2-methylphenyl)piperazin-1-yl]methanone chemical structure, C19H20N2O3, CAS 898645-13-1
1,3-Benzodioxol-5-yl-[4-(2-methylphenyl)piperazin-1-yl]methanone
CAS 898645-13-1C19H20N2O3
1-(1,3-Dioxaindane-5-carbonyl)-4-(3-methylphenyl)piperazine chemical structure, C19H20N2O3, CAS 1050652-60-2
1-(1,3-Dioxaindane-5-carbonyl)-4-(3-methylphenyl)piperazine
CAS 1050652-60-2C19H20N2O3
1-(1,3-Benzodioxol-5-ylcarbonyl)-4-mesitylpiperazine chemical structure, C21H24N2O3, CAS 886137-80-0
1-(1,3-Benzodioxol-5-ylcarbonyl)-4-mesitylpiperazine
CAS 886137-80-0C21H24N2O3
1-(1,3-Benzodioxol-5-ylcarbonyl)-4-(3,4-dimethylphenyl)piperazine chemical structure, C20H22N2O3, CAS 898645-14-2
1-(1,3-Benzodioxol-5-ylcarbonyl)-4-(3,4-dimethylphenyl)piperazine
CAS 898645-14-2C20H22N2O3
1-(2H-1,3-Benzodioxole-5-carbonyl)-4-(3-chloro-4-methylphenyl)piperazine chemical structure, C19H19ClN2O3, CAS 898645-15-3
1-(2H-1,3-Benzodioxole-5-carbonyl)-4-(3-chloro-4-methylphenyl)piperazine
CAS 898645-15-3C19H19ClN2O3