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Murcko scaffold

Pyrazine-2,3-diol scaffold

58 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
8
Chemicals
58
With full pages
4
Scaffold SMILES

O=c1[nH]cc[nH]c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Pyrazine-2,3-diol page
Murcko scaffold O=c1[nH]cc[nH]c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 58 chemicals

5-Chloro-1,4-dimethylpyrazine-2,3-dione chemical structure, C6H7ClN2O2, CAS 87486-42-8
5-Chloro-1,4-dimethylpyrazine-2,3-dione
CAS 87486-42-8C6H7ClN2O2
1,4,5,6-Tetrahydro-5,6-dioxo-2,3-pyrazinedicarbonitrile chemical structure, C6H2N4O2, CAS 36023-64-0
1,4,5,6-Tetrahydro-5,6-dioxo-2,3-pyrazinedicarbonitrile
CAS 36023-64-0C6H2N4O2
Pyrazine-2,3-diol chemical structure, C4H4N2O2, CAS 931-18-0
Pyrazine-2,3-diol
CAS 931-18-0C4H4N2O2
Ethyl 2-(3-hydroxy-2-oxopyrazin-1(2H)-yl)acetate chemical structure, C8H10N2O4, CAS 312904-87-3
Ethyl 2-(3-hydroxy-2-oxopyrazin-1(2H)-yl)acetate
CAS 312904-87-3C8H10N2O4
Ethyl 2-(6-methyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)acetate chemical structure, C9H12N2O4, CAS 221136-61-4
Ethyl 2-(6-methyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)acetate
CAS 221136-61-4C9H12N2O4
Ethyl 6-formyl-3,4-dihydro-2,3-dioxo-1(2H)-pyrazineacetate chemical structure, C9H10N2O5, CAS 312904-93-1
Ethyl 6-formyl-3,4-dihydro-2,3-dioxo-1(2H)-pyrazineacetate
CAS 312904-93-1C9H10N2O5
5-Methylpyrazine-2,3(1H,4H)-dione chemical structure, C5H6N2O2, CAS 32493-61-1
5-Methylpyrazine-2,3(1H,4H)-dione
CAS 32493-61-1C5H6N2O2
5,6-Dihydroxypyrazine-2-carboxylic acid chemical structure, C5H4N2O4, CAS 77168-80-0
5,6-Dihydroxypyrazine-2-carboxylic acid
CAS 77168-80-0C5H4N2O4
1-Ethyl-1,4-dihydropyrazine-2,3-dione chemical structure, C6H8N2O2, CAS 92716-37-5
1-Ethyl-1,4-dihydropyrazine-2,3-dione
CAS 92716-37-5C6H8N2O2
1-Methyl-1,2,3,4-tetrahydropyrazine-2,3-dione chemical structure, C5H6N2O2, CAS 4774-11-2
1-Methyl-1,2,3,4-tetrahydropyrazine-2,3-dione
CAS 4774-11-2C5H6N2O2
1-Propyl-1,4-dihydropyrazine-2,3-dione chemical structure, C7H10N2O2, CAS 92716-38-6
1-Propyl-1,4-dihydropyrazine-2,3-dione
CAS 92716-38-6C7H10N2O2
1-Isopropyl-1,4-dihydropyrazine-2,3-dione chemical structure, C7H10N2O2, CAS 92716-39-7
1-Isopropyl-1,4-dihydropyrazine-2,3-dione
CAS 92716-39-7C7H10N2O2
4-(Dimethylamino)-1H-pyrazine-2,3-dione chemical structure, C6H9N3O2, CAS 92716-47-7
4-(Dimethylamino)-1H-pyrazine-2,3-dione
CAS 92716-47-7C6H9N3O2
5,6-Dioxo-1,4,5,6-tetrahydropyrazine-2,3-dicarboxylic acid chemical structure, C6H4N2O6, CAS 58084-27-8
5,6-Dioxo-1,4,5,6-tetrahydropyrazine-2,3-dicarboxylic acid
CAS 58084-27-8C6H4N2O6
3,4-Dihydro-2,3-dioxo-1(2H)-pyrazinepropanoic acid chemical structure, C7H8N2O4, CAS 1240528-06-6
3,4-Dihydro-2,3-dioxo-1(2H)-pyrazinepropanoic acid
CAS 1240528-06-6C7H8N2O4
2-(4-Methyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)acetic acid chemical structure, C7H8N2O4, CAS 1275729-79-7
2-(4-Methyl-2,3-dioxo-3,4-dihydropyrazin-1(2H)-yl)acetic acid
CAS 1275729-79-7C7H8N2O4
5-Bromo-3-hydroxy-1-methylpyrazin-2(1H)-one chemical structure, C5H5BrN2O2, CAS 1133573-50-8
5-Bromo-3-hydroxy-1-methylpyrazin-2(1H)-one
CAS 1133573-50-8C5H5BrN2O2
3-(4-Methyl-2,3-dioxo-1,2,3,4-tetrahydropyrazin-1-yl)propanoic acid chemical structure, C8H10N2O4, CAS 1466012-97-4
3-(4-Methyl-2,3-dioxo-1,2,3,4-tetrahydropyrazin-1-yl)propanoic acid
CAS 1466012-97-4C8H10N2O4
Methyl 3-(4-methyl-2,3-dioxo-1,2,3,4-tetrahydropyrazin-1-yl)propanoate chemical structure, C9H12N2O4, CAS 1341525-16-3
Methyl 3-(4-methyl-2,3-dioxo-1,2,3,4-tetrahydropyrazin-1-yl)propanoate
CAS 1341525-16-3C9H12N2O4
Ethyl 2,3-dioxo-3,4-dihydropyrazine-1(2H)-carboxylate chemical structure, C7H8N2O4, CAS 1194374-12-3
Ethyl 2,3-dioxo-3,4-dihydropyrazine-1(2H)-carboxylate
CAS 1194374-12-3C7H8N2O4
5,6-Dihydroxy-3-(methoxycarbonyl)pyrazine-2-carboxylic acid chemical structure, C7H6N2O6, CAS 58084-36-9
5,6-Dihydroxy-3-(methoxycarbonyl)pyrazine-2-carboxylic acid
CAS 58084-36-9C7H6N2O6
1-(2-Aminoethyl)-1,2,3,4-tetrahydropyrazine-2,3-dione hydrochloride chemical structure, C6H10ClN3O2, CAS 1955494-37-7
1-(2-Aminoethyl)-1,2,3,4-tetrahydropyrazine-2,3-dione hydrochloride
CAS 1955494-37-7C6H10ClN3O2
1-(2-Aminoethyl)-1,2,3,4-tetrahydropyrazine-2,3-dione chemical structure, C6H9N3O2, CAS 1597847-29-4
1-(2-Aminoethyl)-1,2,3,4-tetrahydropyrazine-2,3-dione
CAS 1597847-29-4C6H9N3O2
6-(Hydroxymethyl)-1-methylpyrazine-2,3(1H,4H)-dione chemical structure, C6H8N2O3, CAS 61481-37-6
6-(Hydroxymethyl)-1-methylpyrazine-2,3(1H,4H)-dione
CAS 61481-37-6C6H8N2O3