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Murcko scaffold

Ring system with 2 rings and 13 atoms

26 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 13
Chemicals: 26
With full pages: 6

Scaffold SMILES

O=C1C=C(Nc2ccccc2)OC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1C=C(Nc2ccccc2)OC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

Ethyl 2-(4-bromoanilino)-4-oxo-4,5-dihydro-3-furancarboxylate chemical structure, C13H12BrNO4, CAS 115320-99-5

Ethyl 2-(4-bromoanilino)-4-oxo-4,5-dihydro-3-furancarboxylate

CAS 115320-99-5C₁₃H₁₂BrNO₄

Ethyl 2-[(3-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C14H15NO5, CAS 30666-31-0

Ethyl 2-[(3-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 30666-31-0C₁₄H₁₅NO₅

Ethyl 2-anilino-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C13H13NO4, CAS 58337-16-9

Ethyl 2-anilino-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 58337-16-9C₁₃H₁₃NO₄

Ethyl 2-((3-chlorophenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C13H12ClNO4, CAS 332174-81-9

Ethyl 2-((3-chlorophenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 332174-81-9C₁₃H₁₂ClNO₄

Ethyl 4-oxo-2-[4-(trifluoromethoxy)anilino]furan-3-carboxylate chemical structure, C14H12F3NO5, CAS 882322-01-2

Ethyl 4-oxo-2-[4-(trifluoromethoxy)anilino]furan-3-carboxylate

CAS 882322-01-2C₁₄H₁₂F₃NO₅

Ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C13H12ClNO4, CAS 58337-17-0

Ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 58337-17-0C₁₃H₁₂ClNO₄

Ethyl 2-[(4-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C14H15NO5, CAS 3148-33-2

Ethyl 2-[(4-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 3148-33-2C₁₄H₁₅NO₅

Ethyl 4-oxo-2-[3-(trifluoromethyl)anilino]furan-3-carboxylate chemical structure, C14H12F3NO4, CAS 115320-97-3

Ethyl 4-oxo-2-[3-(trifluoromethyl)anilino]furan-3-carboxylate

CAS 115320-97-3C₁₄H₁₂F₃NO₄

Ethyl 2-(3,4-dichloroanilino)-4-oxofuran-3-carboxylate chemical structure, C13H11Cl2NO4, CAS 443671-92-9

Ethyl 2-(3,4-dichloroanilino)-4-oxofuran-3-carboxylate

CAS 443671-92-9C₁₃H₁₁Cl₂NO₄

4-Oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid chemical structure, C11H9NO4, CAS 58337-23-8

4-Oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylic acid

CAS 58337-23-8C₁₁H₉NO₄

2-(2-Methoxyanilino)-4-oxo-4,5-dihydrofuran-3-carboxylic acid chemical structure, C12H11NO5, CAS 106212-55-9

2-(2-Methoxyanilino)-4-oxo-4,5-dihydrofuran-3-carboxylic acid

CAS 106212-55-9C₁₂H₁₁NO₅

Ethyl 2-[(2,4-dimethoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C15H17NO6, CAS 92647-60-4

Ethyl 2-[(2,4-dimethoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 92647-60-4C₁₅H₁₇NO₆

Ethyl 2-[(2-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C14H15NO5, CAS 115320-96-2

Ethyl 2-[(2-methoxyphenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 115320-96-2C₁₄H₁₅NO₅

Methyl 4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylate chemical structure, C12H11NO4, CAS 937669-57-3

Methyl 4-oxo-2-(phenylamino)-4,5-dihydrofuran-3-carboxylate

CAS 937669-57-3C₁₂H₁₁NO₄

2-Acetyl-5-anilinofuran-3(2H)-one chemical structure, C12H11NO3, CAS 61418-06-2

2-Acetyl-5-anilinofuran-3(2H)-one

CAS 61418-06-2C₁₂H₁₁NO₃

Ethyl 2[(2-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C13H12ClNO4, CAS 1402059-35-1

Ethyl 2[(2-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 1402059-35-1C₁₃H₁₂ClNO₄

Ethyl 2-((2-hydroxyphenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C13H13NO5, CAS 1402059-39-5

Ethyl 2-((2-hydroxyphenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 1402059-39-5C₁₃H₁₃NO₅

Ethyl 2-{[2-(2-hydroxyethoxy)phenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C15H17NO6, CAS 1402059-40-8

Ethyl 2-{[2-(2-hydroxyethoxy)phenyl]amino}-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 1402059-40-8C₁₅H₁₇NO₆

Ethyl 2-((2-fluorophenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C13H12FNO4, CAS 1402059-42-0

Ethyl 2-((2-fluorophenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 1402059-42-0C₁₃H₁₂FNO₄

Ethyl 4-oxo-2-(o-tolylamino)-4,5-dihydrofuran-3-carboxylate chemical structure, C14H15NO4, CAS 1005769-65-2

Ethyl 4-oxo-2-(o-tolylamino)-4,5-dihydrofuran-3-carboxylate

CAS 1005769-65-2C₁₄H₁₅NO₄

Ethyl 2-((4-isopropylphenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C16H19NO4, CAS 1402059-46-4

Ethyl 2-((4-isopropylphenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 1402059-46-4C₁₆H₁₉NO₄

Ethyl 2-((4-fluorophenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C13H12FNO4, CAS 1402059-49-7

Ethyl 2-((4-fluorophenyl)amino)-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 1402059-49-7C₁₃H₁₂FNO₄

Methyl 2-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate chemical structure, C12H10FNO4, CAS 1402059-52-2

Methyl 2-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

CAS 1402059-52-2C₁₂H₁₀FNO₄

Ethyl 4-oxo-2-{[4-(1-propoxy)phenyl]amino}-4,5-dihydrofuran-3-carboxylate chemical structure, C16H19NO5, CAS 1402059-56-6

Ethyl 4-oxo-2-{[4-(1-propoxy)phenyl]amino}-4,5-dihydrofuran-3-carboxylate

CAS 1402059-56-6C₁₆H₁₉NO₅