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Murcko scaffold

3-Phenylcyclohexanone scaffold

224 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
224
With full pages
21
Scaffold SMILES

O=C1CCCC(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenylcyclohexanone page
Murcko scaffold O=C1CCCC(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 224 chemicals

1,3-Diethyl 4-hydroxy-4-methyl-6-oxo-2-phenyl-1,3-cyclohexanedicarboxylate chemical structure, C19H24O6, CAS 17572-39-3
1,3-Diethyl 4-hydroxy-4-methyl-6-oxo-2-phenyl-1,3-cyclohexanedicarboxylate
CAS 17572-39-3C19H24O6
Ethyl 6-(3,4-dimethoxyphenyl)-2-hydroxy-2-methyl-4-oxocyclohexanecarboxylate chemical structure, C18H24O6, CAS 5415-57-6
Ethyl 6-(3,4-dimethoxyphenyl)-2-hydroxy-2-methyl-4-oxocyclohexanecarboxylate
CAS 5415-57-6C18H24O6
3-Phenylcyclohexanone chemical structure, C12H14O, CAS 20795-53-3
3-Phenylcyclohexanone
CAS 20795-53-3C12H14O
Methyl 3-(2-methoxy-2-oxoethyl)-4-(4-methoxyphenyl)-1-methyl-2-oxocyclohexanecarboxylate chemical structure, C19H24O6, CAS 3950-07-0
Methyl 3-(2-methoxy-2-oxoethyl)-4-(4-methoxyphenyl)-1-methyl-2-oxocyclohexanecarboxylate
CAS 3950-07-0C19H24O6
2,4-Diacetyl-5-hydroxy-5-methyl-3-phenyl-cyclohexanone chemical structure, C17H20O4, CAS 21225-62-7
2,4-Diacetyl-5-hydroxy-5-methyl-3-phenyl-cyclohexanone
CAS 21225-62-7C17H20O4
Diethyl 4-hydroxy-2-(4-methoxyphenyl)-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C20H26O7, CAS 79988-76-4
Diethyl 4-hydroxy-2-(4-methoxyphenyl)-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 79988-76-4C20H26O7
Dimethyl 2-[4-(dimethylamino)phenyl]-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C19H25NO6, CAS 356564-49-3
Dimethyl 2-[4-(dimethylamino)phenyl]-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 356564-49-3C19H25NO6
Diethyl 4-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C20H26O8, CAS 5791-11-7
Diethyl 4-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 5791-11-7C20H26O8
Cyclohexanone, 2,4-diacetyl-5-hydroxy-3-(4-methoxyphenyl)-5-methyl- chemical structure, C18H22O5, CAS 76354-25-1
Cyclohexanone, 2,4-diacetyl-5-hydroxy-3-(4-methoxyphenyl)-5-methyl-
CAS 76354-25-1C18H22O5
2,4-Diacetyl-3-(3,4-dimethoxyphenyl)-5-hydroxy-5-methylcyclohexan-1-one chemical structure, C19H24O6, CAS 471260-01-2
2,4-Diacetyl-3-(3,4-dimethoxyphenyl)-5-hydroxy-5-methylcyclohexan-1-one
CAS 471260-01-2C19H24O6
2,4-Diacetyl-3-(4-bromophenyl)-5-hydroxy-5-methylcyclohexan-1-one chemical structure, C17H19BrO4, CAS 76354-24-0
2,4-Diacetyl-3-(4-bromophenyl)-5-hydroxy-5-methylcyclohexan-1-one
CAS 76354-24-0C17H19BrO4
Dimethyl 2-(2-fluorophenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C17H19FO6, CAS 524945-55-9
Dimethyl 2-(2-fluorophenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 524945-55-9C17H19FO6
Ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-6-oxo-4-phenylcyclohexanecarboxylate chemical structure, C17H18Cl2O4, CAS 462599-79-7
Ethyl 2-(2,2-dichlorovinyl)-4-hydroxy-6-oxo-4-phenylcyclohexanecarboxylate
CAS 462599-79-7C17H18Cl2O4
4-(3-Bromophenyl)-2-oxo-4-hydroxy-6-(2,2-dichlorovinyl)cyclohexanecarboxylic acid ethyl ester chemical structure, C17H17BrCl2O4, CAS 5107-47-1
4-(3-Bromophenyl)-2-oxo-4-hydroxy-6-(2,2-dichlorovinyl)cyclohexanecarboxylic acid ethyl ester
CAS 5107-47-1C17H17BrCl2O4
2,4-Diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl)cyclohexan-1-one chemical structure, C17H19NO6, CAS 105843-01-4
2,4-Diacetyl-5-hydroxy-5-methyl-3-(3-nitrophenyl)cyclohexan-1-one
CAS 105843-01-4C17H19NO6
2,4-Diacetyl-3-[4-(dimethylamino)phenyl]-5-hydroxy-5-methylcyclohexanone chemical structure, C19H25NO4, CAS 76354-26-2
2,4-Diacetyl-3-[4-(dimethylamino)phenyl]-5-hydroxy-5-methylcyclohexanone
CAS 76354-26-2C19H25NO4
Diethyl 2-(4-ethoxyphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C21H28O7, CAS 313270-81-4
Diethyl 2-(4-ethoxyphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 313270-81-4C21H28O7
Diethyl 2-(3-bromo-4-methoxyphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C20H25BrO7, CAS 356564-41-5
Diethyl 2-(3-bromo-4-methoxyphenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 356564-41-5C20H25BrO7
1,3-Diethyl 2-(4-chlorophenyl)-4-hydroxy-4-methyl-6-oxo-1,3-cyclohexanedicarboxylate chemical structure, C19H23ClO6, CAS 294194-13-1
1,3-Diethyl 2-(4-chlorophenyl)-4-hydroxy-4-methyl-6-oxo-1,3-cyclohexanedicarboxylate
CAS 294194-13-1C19H23ClO6
Diethyl 4-hydroxy-4-methyl-2-(4-methylphenyl)-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C20H26O6, CAS 79988-72-0
Diethyl 4-hydroxy-4-methyl-2-(4-methylphenyl)-6-oxocyclohexane-1,3-dicarboxylate
CAS 79988-72-0C20H26O6
Diethyl 4-hydroxy-4-methyl-2-(4-nitrophenyl)-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C19H23NO8, CAS 5610-43-5
Diethyl 4-hydroxy-4-methyl-2-(4-nitrophenyl)-6-oxocyclohexane-1,3-dicarboxylate
CAS 5610-43-5C19H23NO8
1,3-Diethyl 2-(3-chlorophenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C19H23ClO6, CAS 4759-55-1
1,3-Diethyl 2-(3-chlorophenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 4759-55-1C19H23ClO6
Dimethyl 4-hydroxy-4-methyl-6-oxo-2-phenylcyclohexane-1,3-dicarboxylate chemical structure, C17H20O6, CAS 64681-98-7
Dimethyl 4-hydroxy-4-methyl-6-oxo-2-phenylcyclohexane-1,3-dicarboxylate
CAS 64681-98-7C17H20O6
Dimethyl 2-(3,4-dichlorophenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate chemical structure, C17H18Cl2O6, CAS 470691-55-5
Dimethyl 2-(3,4-dichlorophenyl)-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylate
CAS 470691-55-5C17H18Cl2O6