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Murcko scaffold

Ring system with 3 rings and 25 atoms

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
13
With full pages
6
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCN(CCCOc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1ccccc1)N1CCN(CCCOc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

1-[3-(2,5-Dimethylphenoxy)propyl]-4-(4-methylphenyl)sulfonylpiperazine chemical structure, C22H30N2O3S, CAS 593238-19-8
1-[3-(2,5-Dimethylphenoxy)propyl]-4-(4-methylphenyl)sulfonylpiperazine
CAS 593238-19-8C22H30N2O3S
1-[3-(3-Methoxyphenoxy)propyl]-4-(4-methylphenyl)sulfonylpiperazine chemical structure, C21H28N2O4S, CAS 593238-20-1
1-[3-(3-Methoxyphenoxy)propyl]-4-(4-methylphenyl)sulfonylpiperazine
CAS 593238-20-1C21H28N2O4S
1-[3-(2-Chlorophenoxy)propyl]-4-(3,4-dichlorophenyl)sulfonylpiperazine chemical structure, C19H21Cl3N2O3S, CAS 709000-69-1
1-[3-(2-Chlorophenoxy)propyl]-4-(3,4-dichlorophenyl)sulfonylpiperazine
CAS 709000-69-1C19H21Cl3N2O3S
1-[3-(2-Chlorophenoxy)propyl]-4-(4-methylphenyl)sulfonylpiperazine chemical structure, C20H25ClN2O3S, CAS 593238-21-2
1-[3-(2-Chlorophenoxy)propyl]-4-(4-methylphenyl)sulfonylpiperazine
CAS 593238-21-2C20H25ClN2O3S
1-(4-{2-Hydroxy-3-[4-(phenylsulfonyl)-1-piperazinyl]propoxy}-3-methoxyphenyl)ethanone chemical structure, C22H28N2O6S, CAS 694476-65-8
1-(4-{2-Hydroxy-3-[4-(phenylsulfonyl)-1-piperazinyl]propoxy}-3-methoxyphenyl)ethanone
CAS 694476-65-8C22H28N2O6S
N-[4-[4-[3-(2-Chlorophenoxy)propyl]piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C21H26ClN3O4S, CAS 701275-45-8
N-[4-[4-[3-(2-Chlorophenoxy)propyl]piperazin-1-yl]sulfonylphenyl]acetamide
CAS 701275-45-8C21H26ClN3O4S
N-[4-[4-[3-(2,5-Dimethylphenoxy)propyl]piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C23H31N3O4S, CAS 708284-88-2
N-[4-[4-[3-(2,5-Dimethylphenoxy)propyl]piperazin-1-yl]sulfonylphenyl]acetamide
CAS 708284-88-2C23H31N3O4S
N-[4-[4-[3-(3-Methoxyphenoxy)propyl]piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C22H29N3O5S, CAS 709000-03-3
N-[4-[4-[3-(3-Methoxyphenoxy)propyl]piperazin-1-yl]sulfonylphenyl]acetamide
CAS 709000-03-3C22H29N3O5S
N-{4-[(4-{3-[4-(Acetylamino)phenoxy]-2-hydroxypropyl}-1-piperazinyl)sulfonyl]phenyl}acetamide chemical structure, C23H30N4O6S, CAS 825608-30-8
N-{4-[(4-{3-[4-(Acetylamino)phenoxy]-2-hydroxypropyl}-1-piperazinyl)sulfonyl]phenyl}acetamide
CAS 825608-30-8C23H30N4O6S
N-(4-{2-Hydroxy-3-[4-(phenylsulfonyl)piperazinyl]propoxy}phenyl)acetamide chemical structure, C21H27N3O5S, CAS 825608-31-9
N-(4-{2-Hydroxy-3-[4-(phenylsulfonyl)piperazinyl]propoxy}phenyl)acetamide
CAS 825608-31-9C21H27N3O5S
N-(4-(2-Hydroxy-3-(4-tosylpiperazin-1-yl)propoxy)phenyl)acetamide chemical structure, C22H29N3O5S, CAS 111752-50-2
N-(4-(2-Hydroxy-3-(4-tosylpiperazin-1-yl)propoxy)phenyl)acetamide
CAS 111752-50-2C22H29N3O5S
N-[4-(3-{4-[(3,4-Dimethylphenyl)sulfonyl]piperazin-1-yl}-2-hydroxypropoxy)phenyl]acetamide chemical structure, C23H31N3O5S, CAS 825608-32-0
N-[4-(3-{4-[(3,4-Dimethylphenyl)sulfonyl]piperazin-1-yl}-2-hydroxypropoxy)phenyl]acetamide
CAS 825608-32-0C23H31N3O5S
N-(4-(2-Hydroxy-3-(4-(mesitylsulfonyl)piperazin-1-yl)propoxy)phenyl)acetamide chemical structure, C24H33N3O5S, CAS 825608-33-1
N-(4-(2-Hydroxy-3-(4-(mesitylsulfonyl)piperazin-1-yl)propoxy)phenyl)acetamide
CAS 825608-33-1C24H33N3O5S