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Murcko scaffold

3,4-Diphenyl-5H-furan-2-one scaffold

31 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
31
With full pages
5
Scaffold SMILES

O=C1OCC(c2ccccc2)=C1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,4-Diphenyl-5H-furan-2-one page
Murcko scaffold O=C1OCC(c2ccccc2)=C1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

Rofecoxib chemical structure, C17H14O4S, CAS 162011-90-7
Rofecoxib
CAS 162011-90-7C17H14O4S
MF-tricyclic chemical structure, C17H12F2O4S, CAS 162011-83-8
MF-tricyclic
CAS 162011-83-8C17H12F2O4S
3,4-Diphenyl-5H-furan-2-one chemical structure, C16H12O2, CAS 5635-16-5
3,4-Diphenyl-5H-furan-2-one
CAS 5635-16-5C16H12O2
3,4-Diphenyl-5-methyl-2(5H)-furanone chemical structure, C17H14O2, CAS 52313-14-1
3,4-Diphenyl-5-methyl-2(5H)-furanone
CAS 52313-14-1C17H14O2
4-(4-(Methylsulfonyl)phenyl)-3-(P-tolyl)furan-2(5H)-one chemical structure, C18H16O4S, CAS 959003-56-6
4-(4-(Methylsulfonyl)phenyl)-3-(P-tolyl)furan-2(5H)-one
CAS 959003-56-6C18H16O4S
Benzenesulfonamide, 4-(2,5-dihydro-5-oxo-4-phenyl-3-furanyl)- chemical structure, C16H13NO4S, CAS 639785-67-4
Benzenesulfonamide, 4-(2,5-dihydro-5-oxo-4-phenyl-3-furanyl)-
CAS 639785-67-4C16H13NO4S
5,5-Dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone chemical structure, C19H17FO4S, CAS 178402-36-3
5,5-Dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone
CAS 178402-36-3C19H17FO4S
3-(4-Fluorophenyl)-4-(2-fluoro-4-methylsulfonylphenyl)-2,5-dihydro-2-furanone chemical structure, C17H12F2O4S, CAS 376588-53-3
3-(4-Fluorophenyl)-4-(2-fluoro-4-methylsulfonylphenyl)-2,5-dihydro-2-furanone
CAS 376588-53-3C17H12F2O4S
5-Hydroxyrofecoxib chemical structure, C17H14O5S, CAS 185147-17-5
5-Hydroxyrofecoxib
CAS 185147-17-5C17H14O5S
2(5H)-Furanone, 3-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]- chemical structure, C17H13FO4S, CAS 157672-00-9
2(5H)-Furanone, 3-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]-
CAS 157672-00-9C17H13FO4S
2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl- chemical structure, C17H14O2S, CAS 162012-30-8
2(5H)-Furanone, 4-[4-(methylthio)phenyl]-3-phenyl-
CAS 162012-30-8C17H14O2S
2-(Diethylamino)-3,4-diphenyl-2H-furan-5-one chemical structure, C20H21NO2, CAS 193359-63-6
2-(Diethylamino)-3,4-diphenyl-2H-furan-5-one
CAS 193359-63-6C20H21NO2
Benzonitrile, 4-(2,5-dihydro-5-oxo-4-phenyl-3-furanyl)- chemical structure, C17H11NO2, CAS 116156-22-0
Benzonitrile, 4-(2,5-dihydro-5-oxo-4-phenyl-3-furanyl)-
CAS 116156-22-0C17H11NO2
Rofecoxib-d5 chemical structure, C17H14O4S, CAS 544684-93-7
Rofecoxib-d5
CAS 544684-93-7C17H14O4S
5-Ethyl-3,4-diphenylfuran-2(5H)-one chemical structure, C18H16O2, CAS 79379-59-2
5-Ethyl-3,4-diphenylfuran-2(5H)-one
CAS 79379-59-2C18H16O2
5-Ethoxy-3,4-diphenyl-2(5H)-furanone chemical structure, C18H16O3, CAS 79379-66-1
5-Ethoxy-3,4-diphenyl-2(5H)-furanone
CAS 79379-66-1C18H16O3
5-Methoxy-3,4-diphenylfuran-2(5H)-one chemical structure, C17H14O3, CAS 42367-25-9
5-Methoxy-3,4-diphenylfuran-2(5H)-one
CAS 42367-25-9C17H14O3
3-(4-Methoxyphenyl)-5,5-dimethyl-4-phenyl-2(5H)-furanone chemical structure, C19H18O3, CAS 83253-77-4
3-(4-Methoxyphenyl)-5,5-dimethyl-4-phenyl-2(5H)-furanone
CAS 83253-77-4C19H18O3
4-(4-Methoxyphenyl)-3-phenyl-5H-furan-2-one chemical structure, C17H14O3, CAS 110836-03-8
4-(4-Methoxyphenyl)-3-phenyl-5H-furan-2-one
CAS 110836-03-8C17H14O3
3-(3,4-Difluorophenyl)-5-hydroxy-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone chemical structure, C17H12F2O5S, CAS 185147-18-6
3-(3,4-Difluorophenyl)-5-hydroxy-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
CAS 185147-18-6C17H12F2O5S
4-[4-(4-Fluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]benzene-1-sulfonamide chemical structure, C16H12FNO4S, CAS 162012-33-1
4-[4-(4-Fluorophenyl)-5-oxo-2,5-dihydrofuran-3-yl]benzene-1-sulfonamide
CAS 162012-33-1C16H12FNO4S
3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone chemical structure, C17H13ClO4S, CAS 162011-91-8
3-(2-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
CAS 162011-91-8C17H13ClO4S
3-(4-Aminophenyl)-4-(4-methylsulfonylphenyl)-5H-furan-2-one chemical structure, C17H15NO4S, CAS 372107-17-0
3-(4-Aminophenyl)-4-(4-methylsulfonylphenyl)-5H-furan-2-one
CAS 372107-17-0C17H15NO4S
3-(4-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone chemical structure, C17H13ClO4S, CAS 162011-88-3
3-(4-Chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
CAS 162011-88-3C17H13ClO4S