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Murcko scaffold

Ring system with 4 rings and 9 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
9
Chemicals
20
With full pages
4
Scaffold SMILES

C1CC2(C1)OC1CC2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1CC2(C1)OC1CC2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

4-(Hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid chemical structure, C10H14O4, CAS 2490406-06-7
4-(Hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid
CAS 2490406-06-7C10H14O4
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-amine hydrochloride chemical structure, C9H16ClNO, CAS 2490420-58-9
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-amine hydrochloride
CAS 2490420-58-9C9H16ClNO
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-amine chemical structure, C9H15NO, CAS 2490420-57-8
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-amine
CAS 2490420-57-8C9H15NO
(4-Aminospiro[2-oxabicyclo[2.1.1]hexane-3,1'-cyclobutane]-1-yl)methanol chemical structure, C9H15NO2, CAS 2490426-53-2
(4-Aminospiro[2-oxabicyclo[2.1.1]hexane-3,1'-cyclobutane]-1-yl)methanol
CAS 2490426-53-2C9H15NO2
4-({[(tert-Butoxy)carbonyl]amino}methyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid chemical structure, C15H23NO5, CAS 2490374-81-5
4-({[(tert-Butoxy)carbonyl]amino}methyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid
CAS 2490374-81-5C15H23NO5
Ethyl 4-(iodomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate chemical structure, C12H17IO3, CAS 2490400-69-4
Ethyl 4-(iodomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate
CAS 2490400-69-4C12H17IO3
Ethyl 4-(azidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate chemical structure, C12H17N3O3, CAS 2490400-61-6
Ethyl 4-(azidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate
CAS 2490400-61-6C12H17N3O3
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid chemical structure, C10H14O3, CAS 2490400-65-0
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid
CAS 2490400-65-0C10H14O3
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate hydrochloride chemical structure, C12H20ClNO3, CAS 2490398-53-1
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate hydrochloride
CAS 2490398-53-1C12H20ClNO3
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate chemical structure, C12H19NO3, CAS 2490398-52-0
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate
CAS 2490398-52-0C12H19NO3
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid hydrochloride chemical structure, C10H16ClNO3, CAS 2490375-45-4
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid hydrochloride
CAS 2490375-45-4C10H16ClNO3
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid chemical structure, C10H15NO3, CAS 2490375-44-3
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid
CAS 2490375-44-3C10H15NO3
tert-Butyl N-({1-amino-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutan]-4-yl}methyl)carbamate chemical structure, C14H24N2O3, CAS 2490375-50-1
tert-Butyl N-({1-amino-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutan]-4-yl}methyl)carbamate
CAS 2490375-50-1C14H24N2O3
tert-Butyl N-[4-(hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-yl]carbamate chemical structure, C14H23NO4, CAS 2490420-80-7
tert-Butyl N-[4-(hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-yl]carbamate
CAS 2490420-80-7C14H23NO4
Methyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate chemical structure, C11H17NO3, CAS 2580248-97-9
Methyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate
CAS 2580248-97-9C11H17NO3
tert-Butyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate chemical structure, C14H23NO3, CAS 2639406-72-5
tert-Butyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylate
CAS 2639406-72-5C14H23NO3
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutan]-1-amine chemical structure, C9H16N2O, CAS 2639440-94-9
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutan]-1-amine
CAS 2639440-94-9C9H16N2O
4-({[(Prop-2-en-1-yloxy)carbonyl]amino}methyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid chemical structure, C14H19NO5, CAS 2680693-67-6
4-({[(Prop-2-en-1-yloxy)carbonyl]amino}methyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid
CAS 2680693-67-6C14H19NO5
4-(Acetamidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid chemical structure, C12H17NO4, CAS 2680722-80-7
4-(Acetamidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid
CAS 2680722-80-7C12H17NO4
4-[(2,2,2-Trifluoroacetamido)methyl]-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid chemical structure, C12H14F3NO4, CAS 2680690-34-8
4-[(2,2,2-Trifluoroacetamido)methyl]-3-oxaspiro[bicyclo[2.1.1]hexane-2,1'-cyclobutane]-1-carboxylic acid
CAS 2680690-34-8C12H14F3NO4