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Murcko scaffold

Ring system with 4 rings and 9 atoms

49 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
9
Chemicals
49
With full pages
5
Scaffold SMILES

C1C2CC1C1(CNC1)O2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1C2CC1C1(CNC1)O2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

tert-Butyl 1'-amino-4'-methyl-3'-oxaspiro(azetidine-3,2'-bicyclo(2.1.1)hexane)-1-carboxylate chemical structure, C13H22N2O3, CAS 2490405-98-4
tert-Butyl 1'-amino-4'-methyl-3'-oxaspiro(azetidine-3,2'-bicyclo(2.1.1)hexane)-1-carboxylate
CAS 2490405-98-4C13H22N2O3
Ethyl 4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate, trifluoroacetic acid chemical structure, C13H18F3NO6, CAS 2490402-22-5
Ethyl 4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate, trifluoroacetic acid
CAS 2490402-22-5C13H18F3NO6
Ethyl 4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate chemical structure, C11H17NO4, CAS 2490402-21-4
Ethyl 4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate
CAS 2490402-21-4C11H17NO4
1-[(tert-Butoxy)carbonyl]-4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid chemical structure, C14H21NO6, CAS 2490406-13-6
1-[(tert-Butoxy)carbonyl]-4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid
CAS 2490406-13-6C14H21NO6
tert-Butyl 1'-amino-4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate chemical structure, C13H22N2O4, CAS 2490430-16-3
tert-Butyl 1'-amino-4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate
CAS 2490430-16-3C13H22N2O4
tert-Butyl 4'-(aminomethyl)-1'-carbamoyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate hydrochloride chemical structure, C14H24ClN3O4, CAS 2490431-91-7
tert-Butyl 4'-(aminomethyl)-1'-carbamoyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate hydrochloride
CAS 2490431-91-7C14H24ClN3O4
tert-Butyl 4'-(aminomethyl)-1'-carbamoyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate chemical structure, C14H23N3O4, CAS 2490431-90-6
tert-Butyl 4'-(aminomethyl)-1'-carbamoyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate
CAS 2490431-90-6C14H23N3O4
1-tert-Butyl 1'-ethyl 4'-(iodomethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1,1'-dicarboxylate chemical structure, C16H24INO5, CAS 2490398-77-9
1-tert-Butyl 1'-ethyl 4'-(iodomethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1,1'-dicarboxylate
CAS 2490398-77-9C16H24INO5
1-[(tert-Butoxy)carbonyl]-4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid chemical structure, C14H21NO5, CAS 2490400-53-6
1-[(tert-Butoxy)carbonyl]-4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid
CAS 2490400-53-6C14H21NO5
Ethyl 4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate hydrochloride chemical structure, C11H18ClNO3, CAS 2490398-60-0
Ethyl 4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate hydrochloride
CAS 2490398-60-0C11H18ClNO3
Ethyl 4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate chemical structure, C11H17NO3, CAS 2490398-59-7
Ethyl 4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate
CAS 2490398-59-7C11H17NO3
1-tert-Butyl 1'-ethyl 4'-(aminomethyl)-3'-oxaspiro(azetidine-3,2'-bicyclo(2.1.1)hexane)-1,1'-dicarboxylate chemical structure, C16H26N2O5, CAS 2490374-82-6
1-tert-Butyl 1'-ethyl 4'-(aminomethyl)-3'-oxaspiro(azetidine-3,2'-bicyclo(2.1.1)hexane)-1,1'-dicarboxylate
CAS 2490374-82-6C16H26N2O5
Potassium 4'-(aminomethyl)-1-[(tert-butoxy)carbonyl]-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate chemical structure, C14H21KN2O5, CAS 2490398-67-7
Potassium 4'-(aminomethyl)-1-[(tert-butoxy)carbonyl]-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate
CAS 2490398-67-7C14H21KN2O5
4'-(Aminomethyl)-1-[(tert-butoxy)carbonyl]-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid chemical structure, C14H22N2O5, CAS 2490375-46-5
4'-(Aminomethyl)-1-[(tert-butoxy)carbonyl]-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid
CAS 2490375-46-5C14H22N2O5
1-tert-Butyl 1'-ethyl 4'-(azidomethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1,1'-dicarboxylate chemical structure, C16H24N4O5, CAS 2490398-76-8
1-tert-Butyl 1'-ethyl 4'-(azidomethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1,1'-dicarboxylate
CAS 2490398-76-8C16H24N4O5
4'-Methyl-3'-oxaspiro(azetidine-3,2'-bicyclo(2.1.1)hexane)-1'-carbonitrile, trifluoroacetic acid chemical structure, C11H13F3N2O3, CAS 2490401-69-7
4'-Methyl-3'-oxaspiro(azetidine-3,2'-bicyclo(2.1.1)hexane)-1'-carbonitrile, trifluoroacetic acid
CAS 2490401-69-7C11H13F3N2O3
4'-Methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carbonitrile chemical structure, C9H12N2O, CAS 2490400-75-2
4'-Methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carbonitrile
CAS 2490400-75-2C9H12N2O
1'-(2-Chloroacetyl)-1-methylspiro[2-oxabicyclo[2.1.1]hexane-3,3'-azetidine]-4-carbonitrile chemical structure, C11H13ClN2O2, CAS 2490373-91-4
1'-(2-Chloroacetyl)-1-methylspiro[2-oxabicyclo[2.1.1]hexane-3,3'-azetidine]-4-carbonitrile
CAS 2490373-91-4C11H13ClN2O2
1-tert-Butyl 1'-methyl 4'-(azidomethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1,1'-dicarboxylate chemical structure, C15H22N4O5, CAS 2490401-34-6
1-tert-Butyl 1'-methyl 4'-(azidomethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1,1'-dicarboxylate
CAS 2490401-34-6C15H22N4O5
tert-Butyl 1'-{[(tert-butoxy)carbonyl]amino}-4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate chemical structure, C18H30N2O6, CAS 2757912-58-4
tert-Butyl 1'-{[(tert-butoxy)carbonyl]amino}-4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1-carboxylate
CAS 2757912-58-4C18H30N2O6
4'-(Hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid chemical structure, C9H13NO4, CAS 2566444-83-3
4'-(Hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid
CAS 2566444-83-3C9H13NO4
4'-Methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid chemical structure, C9H13NO3, CAS 2566448-37-9
4'-Methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylic acid
CAS 2566448-37-9C9H13NO3
Methyl 4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate chemical structure, C10H15NO4, CAS 2580215-76-3
Methyl 4'-(hydroxymethyl)-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate
CAS 2580215-76-3C10H15NO4
Methyl 4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate chemical structure, C10H15NO3, CAS 2580255-14-5
Methyl 4'-methyl-3'-oxaspiro[azetidine-3,2'-bicyclo[2.1.1]hexane]-1'-carboxylate
CAS 2580255-14-5C10H15NO3