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Murcko scaffold

Ring system with 4 rings and 9 atoms

21 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
9
Chemicals
21
With full pages
5
Scaffold SMILES

C1C2CC1C1(COC1)O2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1C2CC1C1(COC1)O2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

1-Methylspiro[2-oxabicyclo[2.1.1]hexane-3,3'-oxetane]-4-amine chemical structure, C8H13NO2, CAS 2490430-09-4
1-Methylspiro[2-oxabicyclo[2.1.1]hexane-3,3'-oxetane]-4-amine
CAS 2490430-09-4C8H13NO2
(1-Amino-3-oxaspiro(bicyclo(2.1.1)hexane-2,3'-oxetane)-4-yl)methanol chemical structure, C8H13NO3, CAS 2490430-21-0
(1-Amino-3-oxaspiro(bicyclo(2.1.1)hexane-2,3'-oxetane)-4-yl)methanol
CAS 2490430-21-0C8H13NO3
Ethyl 4-(iodomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate chemical structure, C11H15IO4, CAS 2490375-70-5
Ethyl 4-(iodomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate
CAS 2490375-70-5C11H15IO4
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid chemical structure, C9H12O4, CAS 2490375-78-3
4-Methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid
CAS 2490375-78-3C9H12O4
Ethyl 4-(azidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate chemical structure, C11H15N3O4, CAS 2490374-76-8
Ethyl 4-(azidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate
CAS 2490374-76-8C11H15N3O4
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate hydrochloride chemical structure, C11H18ClNO4, CAS 2490400-46-7
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate hydrochloride
CAS 2490400-46-7C11H18ClNO4
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate chemical structure, C11H17NO4, CAS 2490375-55-6
Ethyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate
CAS 2490375-55-6C11H17NO4
4-((((tert-Butoxy)carbonyl)amino)methyl)-3-oxaspiro(bicyclo(2.1.1)hexane-2,3'-oxetane)-1-carboxylic acid chemical structure, C14H21NO6, CAS 2490401-33-5
4-((((tert-Butoxy)carbonyl)amino)methyl)-3-oxaspiro(bicyclo(2.1.1)hexane-2,3'-oxetane)-1-carboxylic acid
CAS 2490401-33-5C14H21NO6
4-(Hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid chemical structure, C9H12O5, CAS 2490400-58-1
4-(Hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid
CAS 2490400-58-1C9H12O5
tert-Butyl N-({1-amino-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-4-yl}methyl)carbamate chemical structure, C13H22N2O4, CAS 2490401-59-5
tert-Butyl N-({1-amino-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-4-yl}methyl)carbamate
CAS 2490401-59-5C13H22N2O4
2-Chloro-N-[1-(hydroxymethyl)spiro[2-oxabicyclo[2.1.1]hexane-3,3'-oxetane]-4-yl]acetamide chemical structure, C10H14ClNO4, CAS 2490374-64-4
2-Chloro-N-[1-(hydroxymethyl)spiro[2-oxabicyclo[2.1.1]hexane-3,3'-oxetane]-4-yl]acetamide
CAS 2490374-64-4C10H14ClNO4
2-Chloro-1-(4-methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetan]-1-yl)ethan-1-one chemical structure, C10H13ClO3, CAS 2573212-77-6
2-Chloro-1-(4-methyl-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetan]-1-yl)ethan-1-one
CAS 2573212-77-6C10H13ClO3
tert-Butyl N-[4-(hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-yl]carbamate chemical structure, C13H21NO5, CAS 2490420-73-8
tert-Butyl N-[4-(hydroxymethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-yl]carbamate
CAS 2490420-73-8C13H21NO5
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid chemical structure, C9H13NO4, CAS 2490401-46-0
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid
CAS 2490401-46-0C9H13NO4
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid hydrochloride chemical structure, C9H14ClNO4, CAS 2490401-54-0
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid hydrochloride
CAS 2490401-54-0C9H14ClNO4
Methyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate chemical structure, C10H15NO4, CAS 2580253-50-3
Methyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate
CAS 2580253-50-3C10H15NO4
tert-Butyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate chemical structure, C13H21NO4, CAS 2639411-52-0
tert-Butyl 4-(aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylate
CAS 2639411-52-0C13H21NO4
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetan]-1-amine chemical structure, C8H14N2O2, CAS 2639425-32-2
4-(Aminomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetan]-1-amine
CAS 2639425-32-2C8H14N2O2
4-({[(Prop-2-en-1-yloxy)carbonyl]amino}methyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid chemical structure, C13H17NO6, CAS 2680771-45-1
4-({[(Prop-2-en-1-yloxy)carbonyl]amino}methyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid
CAS 2680771-45-1C13H17NO6
4-(Acetamidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid chemical structure, C11H15NO5, CAS 2680835-74-7
4-(Acetamidomethyl)-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid
CAS 2680835-74-7C11H15NO5
4-[(2,2,2-Trifluoroacetamido)methyl]-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid chemical structure, C11H12F3NO5, CAS 2680787-33-9
4-[(2,2,2-Trifluoroacetamido)methyl]-3-oxaspiro[bicyclo[2.1.1]hexane-2,3'-oxetane]-1-carboxylic acid
CAS 2680787-33-9C11H12F3NO5