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Murcko scaffold

1-Phenyl-3,4-dihydroisoquinoline scaffold

94 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
94
With full pages
10
Scaffold SMILES

c1ccc(C2=NCCc3ccccc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-3,4-dihydroisoquinoline page
Murcko scaffold c1ccc(C2=NCCc3ccccc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 94 chemicals

Isoquinoline, 3,4-dihydro-1-(p-(isopropylsulfonyl)phenyl)-6,7-dimethoxy- chemical structure, C20H23NO4S, CAS 18453-36-6
Isoquinoline, 3,4-dihydro-1-(p-(isopropylsulfonyl)phenyl)-6,7-dimethoxy-
CAS 18453-36-6C20H23NO4S
Sdz isq 844 chemical structure, C20H23NO5, CAS 143526-87-8
Sdz isq 844
CAS 143526-87-8C20H23NO5
6,7-Isoquinolinediol, 3,4-dihydro-1-(p-(isopropylsulfonyl)phenyl)-, hydrobromide chemical structure, C18H20BrNO4S, CAS 20884-93-9
6,7-Isoquinolinediol, 3,4-dihydro-1-(p-(isopropylsulfonyl)phenyl)-, hydrobromide
CAS 20884-93-9C18H20BrNO4S
6,7-Dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline chemical structure, C20H23NO5, CAS 3161-21-5
6,7-Dimethoxy-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline
CAS 3161-21-5C20H23NO5
RefChem:357337 chemical structure, C17H16N2O4, CAS 60888-85-9
RefChem:357337
CAS 60888-85-9C17H16N2O4
1-Phenyl-3,4-dihydroisoquinoline chemical structure, C15H13N, CAS 52250-50-7
1-Phenyl-3,4-dihydroisoquinoline
CAS 52250-50-7C15H13N
6,7-Dimethoxy-1-phenyl-3,4-dihydroisoquinoline chemical structure, C17H17NO2, CAS 10172-39-1
6,7-Dimethoxy-1-phenyl-3,4-dihydroisoquinoline
CAS 10172-39-1C17H17NO2
AG-690/36164013 chemical structure, C19H21NO2, CAS 204636-06-6
AG-690/36164013
CAS 204636-06-6C19H21NO2
Methyl 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)benzoate chemical structure, C19H19NO4, CAS 155959-66-3
Methyl 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)benzoate
CAS 155959-66-3C19H19NO4
1-(4-tert-Butylphenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline chemical structure, C21H25NO2, CAS 497060-28-3
1-(4-tert-Butylphenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline
CAS 497060-28-3C21H25NO2
6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline chemical structure, C18H19NO3, CAS 15462-83-6
6,7-Dimethoxy-1-(4-methoxyphenyl)-3,4-dihydroisoquinoline
CAS 15462-83-6C18H19NO3
6,7-Dimethoxy-3,3-dimethyl-1-(4-nitrophenyl)-3,4-dihydroisoquinoline chemical structure, C19H20N2O4, CAS 425400-78-8
6,7-Dimethoxy-3,3-dimethyl-1-(4-nitrophenyl)-3,4-dihydroisoquinoline
CAS 425400-78-8C19H20N2O4
1-(5-Chloro-2-nitrophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline chemical structure, C17H15ClN2O4, CAS 62206-13-7
1-(5-Chloro-2-nitrophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline
CAS 62206-13-7C17H15ClN2O4
6,7-Dimethoxy-1-(4-nitrophenyl)-3,4-dihydroisoquinoline chemical structure, C17H16N2O4, CAS 10268-35-6
6,7-Dimethoxy-1-(4-nitrophenyl)-3,4-dihydroisoquinoline
CAS 10268-35-6C17H16N2O4
2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-1-yl)aniline chemical structure, C17H18N2O2, CAS 22276-64-8
2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-1-yl)aniline
CAS 22276-64-8C17H18N2O2
1-(4-Chlorophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline chemical structure, C17H16ClNO2, CAS 76201-90-6
1-(4-Chlorophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline
CAS 76201-90-6C17H16ClNO2
1-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-3,3-dimethylisoquinoline chemical structure, C21H25NO4, CAS 924962-25-4
1-(3,4-Dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-3,3-dimethylisoquinoline
CAS 924962-25-4C21H25NO4
2-(5-Chloro-1-phenyl-3,4-dihydroisoquinolin-3-yl)-N,N-dimethylethan-1-amine--hydrogen chloride (1/2) chemical structure, C19H23Cl3N2, CAS 83657-72-1
2-(5-Chloro-1-phenyl-3,4-dihydroisoquinolin-3-yl)-N,N-dimethylethan-1-amine--hydrogen chloride (1/2)
CAS 83657-72-1C19H23Cl3N2
N,N-Dimethyl-1-(1-phenyl-3,4-dihydroisoquinolin-3-yl)methanamine chemical structure, C18H20N2, CAS 83658-09-7
N,N-Dimethyl-1-(1-phenyl-3,4-dihydroisoquinolin-3-yl)methanamine
CAS 83658-09-7C18H20N2
3-Isoquinolinemethanamine, 3,4-dihydro-N,N-dimethyl-1-(2-fluorophenyl)-, ethanedioate (1:1) chemical structure, C20H21FN2O4, CAS 83658-12-2
3-Isoquinolinemethanamine, 3,4-dihydro-N,N-dimethyl-1-(2-fluorophenyl)-, ethanedioate (1:1)
CAS 83658-12-2C20H21FN2O4
3-Isoquinolinemethanamine, 3,4-dihydro-7-chloro-N,N-dimethyl-1-(2-fluorophenyl)-, hydrochloride, hydrate (1:2:1) chemical structure, C18H20Cl3FN2, CAS 83658-13-3
3-Isoquinolinemethanamine, 3,4-dihydro-7-chloro-N,N-dimethyl-1-(2-fluorophenyl)-, hydrochloride, hydrate (1:2:1)
CAS 83658-13-3C18H20Cl3FN2
1-(7-Chloro-1-phenyl-3,4-dihydroisoquinolin-3-yl)-N,N-dimethylmethanamine chemical structure, C18H19ClN2, CAS 83658-15-5
1-(7-Chloro-1-phenyl-3,4-dihydroisoquinolin-3-yl)-N,N-dimethylmethanamine
CAS 83658-15-5C18H19ClN2
N,N-Dimethyl-1-(7-methyl-1-phenyl-3,4-dihydroisoquinolin-3-yl)methanamine chemical structure, C19H22N2, CAS 83658-16-6
N,N-Dimethyl-1-(7-methyl-1-phenyl-3,4-dihydroisoquinolin-3-yl)methanamine
CAS 83658-16-6C19H22N2
1-(7-Methoxy-1-phenyl-3,4-dihydroisoquinolin-3-yl)-N,N-dimethylmethanamine--hydrogen chloride (1/2) chemical structure, C19H24Cl2N2O, CAS 83658-17-7
1-(7-Methoxy-1-phenyl-3,4-dihydroisoquinolin-3-yl)-N,N-dimethylmethanamine--hydrogen chloride (1/2)
CAS 83658-17-7C19H24Cl2N2O