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Murcko scaffold

3-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)-N-phenylbenzamide scaffold

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
7
With full pages
2
Scaffold SMILES

O=C(Nc1ccccc1)c1cccc(N2C(=O)C3CC=CCC3C2=O)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)-N-phenylbenzamide page
Murcko scaffold O=C(Nc1ccccc1)c1cccc(N2C(=O)C3CC=CCC3C2=O)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

N-(2-Ethylphenyl)-3-(5-methyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)benzamide chemical structure, C24H24N2O3, CAS 421570-05-0
N-(2-Ethylphenyl)-3-(5-methyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)benzamide
CAS 421570-05-0C24H24N2O3
N-(5-Chloro-2-methylphenyl)-3-(5-methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)benzamide chemical structure, C23H21ClN2O3, CAS 428860-10-0
N-(5-Chloro-2-methylphenyl)-3-(5-methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)benzamide
CAS 428860-10-0C23H21ClN2O3
N-(4-Iodophenyl)-3-(5-methyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)benzamide chemical structure, C22H19IN2O3, CAS 429655-38-9
N-(4-Iodophenyl)-3-(5-methyl-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)benzamide
CAS 429655-38-9C22H19IN2O3
3-(5-Methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)-N-[2-(trifluoromethyl)phenyl]benzamide chemical structure, C23H19F3N2O3, CAS 430445-82-2
3-(5-Methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)-N-[2-(trifluoromethyl)phenyl]benzamide
CAS 430445-82-2C23H19F3N2O3
3-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)-N-phenylbenzamide chemical structure, C21H18N2O3, CAS 143725-79-5
3-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)-N-phenylbenzamide
CAS 143725-79-5C21H18N2O3
3-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)-N-(2-methylphenyl)benzamide chemical structure, C22H20N2O3, CAS 355394-12-6
3-(1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-isoindol-2-yl)-N-(2-methylphenyl)benzamide
CAS 355394-12-6C22H20N2O3
N-(4-Bromophenyl)-3-(4-methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)benzamide chemical structure, C22H19BrN2O3, CAS 1212174-86-1
N-(4-Bromophenyl)-3-(4-methyl-1,3-dioxo-3a,4,7,7a-tetrahydroisoindol-2-yl)benzamide
CAS 1212174-86-1C22H19BrN2O3