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Murcko scaffold

Ring system with 2 rings and 12 atoms

28 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
28
With full pages
5
Scaffold SMILES

c1ccc(Sc2nncs2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Sc2nncs2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

1,3,4-Thiadiazol-2-amine, 5-((4-aminophenyl)thio)- chemical structure, C8H8N4S2, CAS 64070-79-7
1,3,4-Thiadiazol-2-amine, 5-((4-aminophenyl)thio)-
CAS 64070-79-7C8H8N4S2
5-[(4-Nitrophenyl)sulfanyl]-1,3,4-thiadiazol-2-amine chemical structure, C8H6N4O2S2, CAS 78305-03-0
5-[(4-Nitrophenyl)sulfanyl]-1,3,4-thiadiazol-2-amine
CAS 78305-03-0C8H6N4O2S2
1-[4-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]ethanone chemical structure, C11H9N3O3S2, CAS 332860-86-3
1-[4-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanyl]-3-nitrophenyl]ethanone
CAS 332860-86-3C11H9N3O3S2
N-(5-{[4-(Dimethylamino)phenyl]sulfanyl}-1,3,4-thiadiazol-2-yl)propanamide chemical structure, C13H16N4OS2, CAS 767346-67-8
N-(5-{[4-(Dimethylamino)phenyl]sulfanyl}-1,3,4-thiadiazol-2-yl)propanamide
CAS 767346-67-8C13H16N4OS2
2-(2-Chloro-4-nitrophenyl)sulfanyl-5-methyl-1,3,4-thiadiazole chemical structure, C9H6ClN3O2S2, CAS 353256-59-4
2-(2-Chloro-4-nitrophenyl)sulfanyl-5-methyl-1,3,4-thiadiazole
CAS 353256-59-4C9H6ClN3O2S2
2-[(4,5-Dichloro-2-nitrophenyl)thio]-5-methyl-1,3,4-thiadiazole chemical structure, C9H5Cl2N3O2S2, CAS 218156-17-3
2-[(4,5-Dichloro-2-nitrophenyl)thio]-5-methyl-1,3,4-thiadiazole
CAS 218156-17-3C9H5Cl2N3O2S2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-5-nitrobenzonitrile chemical structure, C9H5N5O2S2, CAS 175135-68-9
2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-5-nitrobenzonitrile
CAS 175135-68-9C9H5N5O2S2
2-Bromo-N-(5-{[2,6-dinitro-4-(trifluoromethyl)phenyl]thio}-1,3,4-thiadiazol-2-yl)acetamide chemical structure, C11H5BrF3N5O5S2, CAS 680579-94-6
2-Bromo-N-(5-{[2,6-dinitro-4-(trifluoromethyl)phenyl]thio}-1,3,4-thiadiazol-2-yl)acetamide
CAS 680579-94-6C11H5BrF3N5O5S2
2-Methyl-5-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-1,3,4-thiadiazole chemical structure, C10H6F3N3O2S2, CAS 337498-78-9
2-Methyl-5-[2-nitro-4-(trifluoromethyl)phenyl]sulfanyl-1,3,4-thiadiazole
CAS 337498-78-9C10H6F3N3O2S2
2-(4-Chloro-2-nitrophenyl)sulfanyl-5-methyl-1,3,4-thiadiazole chemical structure, C9H6ClN3O2S2, CAS 909379-38-0
2-(4-Chloro-2-nitrophenyl)sulfanyl-5-methyl-1,3,4-thiadiazole
CAS 909379-38-0C9H6ClN3O2S2
5-{[4-(Dimethylamino)phenyl]sulfanyl}-1,3,4-thiadiazol-2-amine chemical structure, C10H12N4S2, CAS 299933-42-9
5-{[4-(Dimethylamino)phenyl]sulfanyl}-1,3,4-thiadiazol-2-amine
CAS 299933-42-9C10H12N4S2
2-[(3,5-Dimethylphenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole chemical structure, C11H9F3N2S2, CAS 62617-37-2
2-[(3,5-Dimethylphenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole
CAS 62617-37-2C11H9F3N2S2
4-(1,3,4-Thiadiazol-2-ylsulfanyl)aniline chemical structure, C8H7N3S2, CAS 1019121-55-1
4-(1,3,4-Thiadiazol-2-ylsulfanyl)aniline
CAS 1019121-55-1C8H7N3S2
3-Chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)aniline chemical structure, C8H6ClN3S2, CAS 1019441-76-9
3-Chloro-4-(1,3,4-thiadiazol-2-ylsulfanyl)aniline
CAS 1019441-76-9C8H6ClN3S2
2-(1,3,4-Thiadiazol-2-ylsulfanyl)aniline chemical structure, C8H7N3S2, CAS 1019121-56-2
2-(1,3,4-Thiadiazol-2-ylsulfanyl)aniline
CAS 1019121-56-2C8H7N3S2
4-(1,3,4-Thiadiazol-2-ylsulfanyl)aniline dihydrochloride chemical structure, C8H9Cl2N3S2, CAS 1193388-54-3
4-(1,3,4-Thiadiazol-2-ylsulfanyl)aniline dihydrochloride
CAS 1193388-54-3C8H9Cl2N3S2
2-Methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]aniline chemical structure, C10H11N3S2, CAS 1178072-62-2
2-Methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]aniline
CAS 1178072-62-2C10H11N3S2
2-[(3,4-Dichlorophenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole chemical structure, C9H3Cl2F3N2S2, CAS 62616-63-1
2-[(3,4-Dichlorophenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole
CAS 62616-63-1C9H3Cl2F3N2S2
2-{[5-(Butylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}benzene-1,4-diol chemical structure, C12H14N2O2S3, CAS 191931-20-1
2-{[5-(Butylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}benzene-1,4-diol
CAS 191931-20-1C12H14N2O2S3
2-[(2,4-Dinitrophenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole chemical structure, C9H3F3N4O4S2, CAS 62616-95-9
2-[(2,4-Dinitrophenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole
CAS 62616-95-9C9H3F3N4O4S2
2-{[5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl]sulfanyl}benzoic acid chemical structure, C10H5F3N2O2S2, CAS 62616-94-8
2-{[5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl]sulfanyl}benzoic acid
CAS 62616-94-8C10H5F3N2O2S2
2-(Trifluoromethyl)-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1,3,4-thiadiazole chemical structure, C10H4F6N2S2, CAS 62616-91-5
2-(Trifluoromethyl)-5-{[3-(trifluoromethyl)phenyl]sulfanyl}-1,3,4-thiadiazole
CAS 62616-91-5C10H4F6N2S2
2-[(2,4-Dichlorophenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole chemical structure, C9H3Cl2F3N2S2, CAS 62616-90-4
2-[(2,4-Dichlorophenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole
CAS 62616-90-4C9H3Cl2F3N2S2
2-[(2,6-Dimethoxyphenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole chemical structure, C11H9F3N2O2S2, CAS 62616-89-1
2-[(2,6-Dimethoxyphenyl)sulfanyl]-5-(trifluoromethyl)-1,3,4-thiadiazole
CAS 62616-89-1C11H9F3N2O2S2