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Murcko scaffold

Ring system with 3 rings and 20 atoms

43 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
43
With full pages
6
Scaffold SMILES

O=C(C=Cc1ccccc1)c1ccc2ccccc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)c1ccc2ccccc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 43 of 43 chemicals

2-Propen-1-one, 3-[4-(dimethylamino)phenyl]-1-(2-naphthalenyl)- chemical structure, C21H19NO, CAS 57221-72-4
2-Propen-1-one, 3-[4-(dimethylamino)phenyl]-1-(2-naphthalenyl)-
CAS 57221-72-4C21H19NO
3-(2-Chlorophenyl)-1-(2-naphthyl)prop-2-en-1-one chemical structure, C19H13ClO, CAS 57221-64-4
3-(2-Chlorophenyl)-1-(2-naphthyl)prop-2-en-1-one
CAS 57221-64-4C19H13ClO
2-[2,6-Dibromo-4-[3-(2-naphthalenyl)-3-oxo-1-propen-1-yl]phenoxy]acetic acid chemical structure, C21H14Br2O4, CAS 284488-55-7
2-[2,6-Dibromo-4-[3-(2-naphthalenyl)-3-oxo-1-propen-1-yl]phenoxy]acetic acid
CAS 284488-55-7C21H14Br2O4
3-(3,5-Dimethoxyphenyl)-1-naphthalen-2-ylprop-2-en-1-one chemical structure, C21H18O3, CAS 175205-23-9
3-(3,5-Dimethoxyphenyl)-1-naphthalen-2-ylprop-2-en-1-one
CAS 175205-23-9C21H18O3
1-Naphthalen-2-yl-3-(4-nitrophenyl)prop-2-en-1-one chemical structure, C19H13NO3, CAS 62918-37-0
1-Naphthalen-2-yl-3-(4-nitrophenyl)prop-2-en-1-one
CAS 62918-37-0C19H13NO3
2-Propen-1-one, 3-[4-(methylthio)phenyl]-1-(2-naphthalenyl)- chemical structure, C20H16OS, CAS 169259-39-6
2-Propen-1-one, 3-[4-(methylthio)phenyl]-1-(2-naphthalenyl)-
CAS 169259-39-6C20H16OS
3-(3-Butoxyphenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one chemical structure, C23H22O3, CAS 256348-48-8
3-(3-Butoxyphenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one
CAS 256348-48-8C23H22O3
4-(3-Naphthalen-2-yl-3-oxoprop-1-enyl)benzonitrile chemical structure, C20H13NO, CAS 62584-65-0
4-(3-Naphthalen-2-yl-3-oxoprop-1-enyl)benzonitrile
CAS 62584-65-0C20H13NO
1-(1-Hydroxynaphthalen-2-yl)-3-(4-methoxyphenyl)prop-2-en-1-one chemical structure, C20H16O3, CAS 40649-75-0
1-(1-Hydroxynaphthalen-2-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
CAS 40649-75-0C20H16O3
3-[4-(Dimethylamino)phenyl]-1-(2-naphthyl)prop-2-en-1-one chemical structure, C21H19NO, CAS 104765-78-8
3-[4-(Dimethylamino)phenyl]-1-(2-naphthyl)prop-2-en-1-one
CAS 104765-78-8C21H19NO
(E)-1-(1-Hydroxynaphthalen-2-yl)-3-phenylprop-2-en-1-one chemical structure, C19H14O2, CAS 125574-15-4
(E)-1-(1-Hydroxynaphthalen-2-yl)-3-phenylprop-2-en-1-one
CAS 125574-15-4C19H14O2
1-(2-Naphthyl)-3-phenylprop-2-en-1-one chemical structure, C19H14O, CAS 53744-34-6
1-(2-Naphthyl)-3-phenylprop-2-en-1-one
CAS 53744-34-6C19H14O
3-(4-Chlorophenyl)-1-(2-naphthyl)prop-2-en-1-one chemical structure, C19H13ClO, CAS 52601-58-8
3-(4-Chlorophenyl)-1-(2-naphthyl)prop-2-en-1-one
CAS 52601-58-8C19H13ClO
3-(3-Nitrophenyl)-2'-acrylonaphthone chemical structure, C19H13NO3, CAS 22290-84-2
3-(3-Nitrophenyl)-2'-acrylonaphthone
CAS 22290-84-2C19H13NO3
3-(4-Methoxyphenyl)-1-(2-naphthyl)prop-2-en-1-one chemical structure, C20H16O2, CAS 22359-67-7
3-(4-Methoxyphenyl)-1-(2-naphthyl)prop-2-en-1-one
CAS 22359-67-7C20H16O2
3-(2,4-Dichlorophenyl)-2'-acrylonaphthone chemical structure, C19H12Cl2O, CAS 52601-59-9
3-(2,4-Dichlorophenyl)-2'-acrylonaphthone
CAS 52601-59-9C19H12Cl2O
1-(2-Naphthyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C22H20O4, CAS 944443-39-4
1-(2-Naphthyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
CAS 944443-39-4C22H20O4
2-Propen-1-one, 3-(2-chlorophenyl)-1-(2-naphthalenyl)-, (E)- chemical structure, C19H13ClO, CAS 183164-47-8
2-Propen-1-one, 3-(2-chlorophenyl)-1-(2-naphthalenyl)-, (E)-
CAS 183164-47-8C19H13ClO
1-(2-Naphthyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one chemical structure, C20H13F3O, CAS 1352444-96-2
1-(2-Naphthyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
CAS 1352444-96-2C20H13F3O
3-(4-Fluorophenyl)-1-(2-naphthyl)prop-2-en-1-one chemical structure, C19H13FO, CAS 104765-79-9
3-(4-Fluorophenyl)-1-(2-naphthyl)prop-2-en-1-one
CAS 104765-79-9C19H13FO
1-(6-Methoxy-2-naphthyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one chemical structure, C21H15F3O2, CAS 258518-47-7
1-(6-Methoxy-2-naphthyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
CAS 258518-47-7C21H15F3O2
3-(3-Hydroxy-4-methoxyphenyl)-1-(2-naphthyl)prop-2-en-1-one chemical structure, C20H16O3, CAS 944443-38-3
3-(3-Hydroxy-4-methoxyphenyl)-1-(2-naphthyl)prop-2-en-1-one
CAS 944443-38-3C20H16O3
(E)-3-(4-Chlorophenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one chemical structure, C19H13ClO2, CAS 1352993-59-9
(E)-3-(4-Chlorophenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one
CAS 1352993-59-9C19H13ClO2
(E)-3-(2,3-Dimethoxyphenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one chemical structure, C21H18O4, CAS 1367707-37-6
(E)-3-(2,3-Dimethoxyphenyl)-1-(1-hydroxynaphthalen-2-yl)prop-2-en-1-one
CAS 1367707-37-6C21H18O4