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Murcko scaffold

Ring system with 2 rings and 11 atoms

10 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 11
Chemicals: 10
With full pages: 3

Scaffold SMILES

C1=CC(c2cccs2)C=CO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C1=CC(c2cccs2)C=CO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

5-Acetyl-2-amino-6-methyl-4-(2-thienyl)-4H-pyran-3-carbonitrile chemical structure, C13H12N2O2S, CAS 128453-25-8

5-Acetyl-2-amino-6-methyl-4-(2-thienyl)-4H-pyran-3-carbonitrile

CAS 128453-25-8C₁₃H₁₂N₂O₂S

Ethyl 6-amino-4-(5-bromothiophen-2-yl)-5-cyano-2-methyl-4H-pyran-3-carboxylate chemical structure, C14H13BrN2O3S, CAS 331951-07-6

Ethyl 6-amino-4-(5-bromothiophen-2-yl)-5-cyano-2-methyl-4H-pyran-3-carboxylate

CAS 331951-07-6C₁₄H₁₃BrN₂O₃S

Ethyl 6-amino-5-cyano-2-methyl-4-(2-thienyl)-4H-pyran-3-carboxylate chemical structure, C14H14N2O3S, CAS 117109-73-6

Ethyl 6-amino-5-cyano-2-methyl-4-(2-thienyl)-4H-pyran-3-carboxylate

CAS 117109-73-6C₁₄H₁₄N₂O₃S

Ethyl 6-amino-4-(5-butylthiophen-2-yl)-5-cyano-2-methyl-4H-pyran-3-carboxylate chemical structure, C18H22N2O3S, CAS 311324-70-6

Ethyl 6-amino-4-(5-butylthiophen-2-yl)-5-cyano-2-methyl-4H-pyran-3-carboxylate

CAS 311324-70-6C₁₈H₂₂N₂O₃S

Methyl 6-amino-4-(4-bromo-5-ethylthiophen-2-yl)-5-cyano-2-methyl-4H-pyran-3-carboxylate chemical structure, C15H15BrN2O3S, CAS 329693-48-3

Methyl 6-amino-4-(4-bromo-5-ethylthiophen-2-yl)-5-cyano-2-methyl-4H-pyran-3-carboxylate

CAS 329693-48-3C₁₅H₁₅BrN₂O₃S

Methyl 6-amino-5-cyano-4-(5-ethylthiophen-2-yl)-2-methyl-4H-pyran-3-carboxylate chemical structure, C15H16N2O3S, CAS 329693-47-2

Methyl 6-amino-5-cyano-4-(5-ethylthiophen-2-yl)-2-methyl-4H-pyran-3-carboxylate

CAS 329693-47-2C₁₅H₁₆N₂O₃S

Ethyl 6-amino-5-cyano-2-methyl-4-(5-methylthiophen-2-yl)-4H-pyran-3-carboxylate chemical structure, C15H16N2O3S, CAS 329693-49-4

Ethyl 6-amino-5-cyano-2-methyl-4-(5-methylthiophen-2-yl)-4H-pyran-3-carboxylate

CAS 329693-49-4C₁₅H₁₆N₂O₃S

Ethyl 6-amino-5-cyano-2-(2-ethoxy-2-oxoethyl)-4-(thiophen-2-yl)-4H-pyran-3-carboxylate chemical structure, C17H18N2O5S, CAS 313379-37-2

Ethyl 6-amino-5-cyano-2-(2-ethoxy-2-oxoethyl)-4-(thiophen-2-yl)-4H-pyran-3-carboxylate

CAS 313379-37-2C₁₇H₁₈N₂O₅S

Ethyl 6-amino-2-(chloromethyl)-5-cyano-4-(thiophen-2-yl)-4H-pyran-3-carboxylate chemical structure, C14H13ClN2O3S, CAS 339158-74-6

Ethyl 6-amino-2-(chloromethyl)-5-cyano-4-(thiophen-2-yl)-4H-pyran-3-carboxylate

CAS 339158-74-6C₁₄H₁₃ClN₂O₃S

Isopropyl 6-amino-5-cyano-2-methyl-4-(2-thienyl)-4H-pyran-3-carboxylate chemical structure, C15H16N2O3S, CAS 312519-66-7

Isopropyl 6-amino-5-cyano-2-methyl-4-(2-thienyl)-4H-pyran-3-carboxylate

CAS 312519-66-7C₁₅H₁₆N₂O₃S