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Murcko scaffold

8-(1-Piperazinyl)quinoline scaffold

27 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
27
With full pages
5
Scaffold SMILES

c1cnc2c(N3CCNCC3)cccc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 8-(1-Piperazinyl)quinoline page
Murcko scaffold c1cnc2c(N3CCNCC3)cccc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

8-(3,5-Dimethylpiperazin-1-yl)-5-nitroquinoline chemical structure, C15H18N4O2, CAS 294194-92-6
8-(3,5-Dimethylpiperazin-1-yl)-5-nitroquinoline
CAS 294194-92-6C15H18N4O2
2-[4-(5-Nitroquinolin-8-yl)piperazin-1-yl]ethanol chemical structure, C15H18N4O3, CAS 300719-59-9
2-[4-(5-Nitroquinolin-8-yl)piperazin-1-yl]ethanol
CAS 300719-59-9C15H18N4O3
5-Nitro-8-piperazin-1-ylquinoline chemical structure, C13H14N4O2, CAS 294194-88-0
5-Nitro-8-piperazin-1-ylquinoline
CAS 294194-88-0C13H14N4O2
8-(4-Methylpiperazin-1-yl)-5-nitroquinoline chemical structure, C14H16N4O2, CAS 294194-90-4
8-(4-Methylpiperazin-1-yl)-5-nitroquinoline
CAS 294194-90-4C14H16N4O2
8-(4-Methylsulfonylpiperazin-1-yl)-5-nitroquinoline chemical structure, C14H16N4O4S, CAS 330634-07-6
8-(4-Methylsulfonylpiperazin-1-yl)-5-nitroquinoline
CAS 330634-07-6C14H16N4O4S
2-Methyl-8-(piperazin-1-yl)quinoline chemical structure, C14H17N3, CAS 282547-42-6
2-Methyl-8-(piperazin-1-yl)quinoline
CAS 282547-42-6C14H17N3
8-(1-Piperazinyl)quinoline chemical structure, C13H15N3, CAS 98223-97-3
8-(1-Piperazinyl)quinoline
CAS 98223-97-3C13H15N3
8-(4-t-Butyloxycarbonylpiperazin-1-yl)quinoline chemical structure, C18H23N3O2, CAS 385821-39-6
8-(4-t-Butyloxycarbonylpiperazin-1-yl)quinoline
CAS 385821-39-6C18H23N3O2
8-(Piperazin-1-yl)quinoline dihydrochloride chemical structure, C13H17Cl2N3, CAS 1177353-50-2
8-(Piperazin-1-yl)quinoline dihydrochloride
CAS 1177353-50-2C13H17Cl2N3
6-Methoxy-8-(piperazin-1-yl)quinoline chemical structure, C14H17N3O, CAS 282547-38-0
6-Methoxy-8-(piperazin-1-yl)quinoline
CAS 282547-38-0C14H17N3O
6-Methyl-8-(piperazin-1-yl)quinoline chemical structure, C14H17N3, CAS 796851-63-3
6-Methyl-8-(piperazin-1-yl)quinoline
CAS 796851-63-3C14H17N3
8-(4-Methylpiperazin-1-yl)quinoline chemical structure, C14H17N3, CAS 855761-66-9
8-(4-Methylpiperazin-1-yl)quinoline
CAS 855761-66-9C14H17N3
tert-Butyl 4-(5-nitroquinolin-8-yl)piperazine-1-carboxylate chemical structure, C18H22N4O4, CAS 1133115-74-8
tert-Butyl 4-(5-nitroquinolin-8-yl)piperazine-1-carboxylate
CAS 1133115-74-8C18H22N4O4
1,1-Dimethylethyl 4-(5-chloro-8-quinolinyl)-1-piperazinecarboxylate chemical structure, C18H22ClN3O2, CAS 796851-16-6
1,1-Dimethylethyl 4-(5-chloro-8-quinolinyl)-1-piperazinecarboxylate
CAS 796851-16-6C18H22ClN3O2
6-Fluoro-8-(piperazin-1-yl)quinoline chemical structure, C13H14FN3, CAS 282547-87-9
6-Fluoro-8-(piperazin-1-yl)quinoline
CAS 282547-87-9C13H14FN3
tert-Butyl 4-(6-fluoroquinolin-8-yl)piperazine-1-carboxylate chemical structure, C18H22FN3O2, CAS 796851-14-4
tert-Butyl 4-(6-fluoroquinolin-8-yl)piperazine-1-carboxylate
CAS 796851-14-4C18H22FN3O2
1,1-Dimethylethyl 4-(3-iodo-8-quinolinyl)-1-piperazinecarboxylate chemical structure, C18H22IN3O2, CAS 958651-49-5
1,1-Dimethylethyl 4-(3-iodo-8-quinolinyl)-1-piperazinecarboxylate
CAS 958651-49-5C18H22IN3O2
3-Bromo-8-(4-methyl-piperazin-1-yl)-quinoline chemical structure, C14H16BrN3, CAS 607743-05-5
3-Bromo-8-(4-methyl-piperazin-1-yl)-quinoline
CAS 607743-05-5C14H16BrN3
3-Iodo-8-(4-methyl-piperazin-1-yl)-quinoline chemical structure, C14H16IN3, CAS 607743-06-6
3-Iodo-8-(4-methyl-piperazin-1-yl)-quinoline
CAS 607743-06-6C14H16IN3
6-Fluoro-4-methoxy-8-(4-methylpiperazin-1-yl)quinoline-2-carboxylic acid hydrochloride chemical structure, C16H19ClFN3O3, CAS 442549-62-4
6-Fluoro-4-methoxy-8-(4-methylpiperazin-1-yl)quinoline-2-carboxylic acid hydrochloride
CAS 442549-62-4C16H19ClFN3O3
6-Fluoro-4-methoxy-8-(4-methyl-piperazin-1-yl)-quinoline-2-carboxylic acid methyl ester chemical structure, C17H20FN3O3, CAS 442549-61-3
6-Fluoro-4-methoxy-8-(4-methyl-piperazin-1-yl)-quinoline-2-carboxylic acid methyl ester
CAS 442549-61-3C17H20FN3O3
tert-Butyl 4-(2-methoxyquinolin-8-yl)piperazine-1-carboxylate chemical structure, C19H25N3O3, CAS 846038-40-2
tert-Butyl 4-(2-methoxyquinolin-8-yl)piperazine-1-carboxylate
CAS 846038-40-2C19H25N3O3
6-Fluoro-8-(piperazin-1-yl)quinoline hydrochloride chemical structure, C13H15ClFN3, CAS 1956310-65-8
6-Fluoro-8-(piperazin-1-yl)quinoline hydrochloride
CAS 1956310-65-8C13H15ClFN3
tert-Butyl 4-(5-aminoquinolin-8-yl)piperazine-1-carboxylate chemical structure, C18H24N4O2, CAS 1373232-98-4
tert-Butyl 4-(5-aminoquinolin-8-yl)piperazine-1-carboxylate
CAS 1373232-98-4C18H24N4O2