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Murcko scaffold

2-Benzylpyrimidin-4(3H)-one scaffold

38 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
38
With full pages
5
Scaffold SMILES

O=c1ccnc(Cc2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Benzylpyrimidin-4(3H)-one page
Murcko scaffold O=c1ccnc(Cc2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

Ethyl 2-benzyl-4-hydroxy-5-pyrimidinecarboxylate chemical structure, C14H14N2O3, CAS 188937-22-6
Ethyl 2-benzyl-4-hydroxy-5-pyrimidinecarboxylate
CAS 188937-22-6C14H14N2O3
4(1H)-Pyrimidinone, 5-fluoro-2-((2-methylphenyl)methyl)- chemical structure, C12H11FN2O, CAS 143328-93-2
4(1H)-Pyrimidinone, 5-fluoro-2-((2-methylphenyl)methyl)-
CAS 143328-93-2C12H11FN2O
4(1H)-Pyrimidinone, 2-((2,6-dichlorophenyl)methyl)-5-fluoro- chemical structure, C11H7Cl2FN2O, CAS 143328-96-5
4(1H)-Pyrimidinone, 2-((2,6-dichlorophenyl)methyl)-5-fluoro-
CAS 143328-96-5C11H7Cl2FN2O
4(1H)-Pyrimidinone, 2-((4-bromophenyl)methyl)-5-fluoro- chemical structure, C11H8BrFN2O, CAS 132901-23-6
4(1H)-Pyrimidinone, 2-((4-bromophenyl)methyl)-5-fluoro-
CAS 132901-23-6C11H8BrFN2O
2-[(2,4-Difluorophenyl)methyl]-5-fluoro-1H-pyrimidin-6-one chemical structure, C11H7F3N2O, CAS 139161-56-1
2-[(2,4-Difluorophenyl)methyl]-5-fluoro-1H-pyrimidin-6-one
CAS 139161-56-1C11H7F3N2O
Ctk1E2618 chemical structure, C13H14N2O3, CAS 55342-68-2
Ctk1E2618
CAS 55342-68-2C13H14N2O3
2-((4-Chlorophenyl)methyl)-4(3H)-pyrimidinone chemical structure, C11H9ClN2O, CAS 106690-54-4
2-((4-Chlorophenyl)methyl)-4(3H)-pyrimidinone
CAS 106690-54-4C11H9ClN2O
2-Benzyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C12H10N2O3, CAS 944889-04-7
2-Benzyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid
CAS 944889-04-7C12H10N2O3
2-(3,4-Dimethoxybenzyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylic acid chemical structure, C14H14N2O5, CAS 56406-38-3
2-(3,4-Dimethoxybenzyl)-6-oxo-1,6-dihydro-5-pyrimidinecarboxylic acid
CAS 56406-38-3C14H14N2O5
2-(2-Benzyl-6-oxo-1,6-dihydropyrimidin-5-yl)acetic acid chemical structure, C13H12N2O3, CAS 896939-11-0
2-(2-Benzyl-6-oxo-1,6-dihydropyrimidin-5-yl)acetic acid
CAS 896939-11-0C13H12N2O3
2-(4-Methoxybenzyl)-4,6-pyrimidinediol chemical structure, C12H12N2O3, CAS 16953-21-2
2-(4-Methoxybenzyl)-4,6-pyrimidinediol
CAS 16953-21-2C12H12N2O3
Ethyl 4-hydroxy-2-(3',4'-dichlorobenzyl)pyrimidine-5-carboxylate chemical structure, C14H12Cl2N2O3, CAS 188937-48-6
Ethyl 4-hydroxy-2-(3',4'-dichlorobenzyl)pyrimidine-5-carboxylate
CAS 188937-48-6C14H12Cl2N2O3
2-Benzylpyrimidine-4,6-diol chemical structure, C11H10N2O2, CAS 3740-83-8
2-Benzylpyrimidine-4,6-diol
CAS 3740-83-8C11H10N2O2
2-Benzylpyrimidin-4(3H)-one chemical structure, C11H10N2O, CAS 22404-52-0
2-Benzylpyrimidin-4(3H)-one
CAS 22404-52-0C11H10N2O
4(1H)-Pyrimidinone,6-hydroxy-2-[(4-methylphenyl)methyl]- chemical structure, C12H12N2O2, CAS 620984-52-3
4(1H)-Pyrimidinone,6-hydroxy-2-[(4-methylphenyl)methyl]-
CAS 620984-52-3C12H12N2O2
2-(3-Phenylpentan-3-yl)-3,4-dihydropyrimidin-4-one chemical structure, C15H18N2O, CAS 1273784-51-2
2-(3-Phenylpentan-3-yl)-3,4-dihydropyrimidin-4-one
CAS 1273784-51-2C15H18N2O
2-Benzyl-3-methyl-3H-pyrimidin-4-one chemical structure, C12H12N2O, CAS 890021-26-8
2-Benzyl-3-methyl-3H-pyrimidin-4-one
CAS 890021-26-8C12H12N2O
2-Benzyl-5-bromo-3-methylpyrimidin-4(3H)-one chemical structure, C12H11BrN2O, CAS 890021-27-9
2-Benzyl-5-bromo-3-methylpyrimidin-4(3H)-one
CAS 890021-27-9C12H11BrN2O
Ethyl 2-(3-chlorobenzyl)-6-oxo-1,6-dihydro-pyrimidine-5-carboxylate chemical structure, C14H13ClN2O3, CAS 1273315-56-2
Ethyl 2-(3-chlorobenzyl)-6-oxo-1,6-dihydro-pyrimidine-5-carboxylate
CAS 1273315-56-2C14H13ClN2O3
2-Benzyl-5-bromopyrimidin-4(3H)-one chemical structure, C11H9BrN2O, CAS 946505-10-8
2-Benzyl-5-bromopyrimidin-4(3H)-one
CAS 946505-10-8C11H9BrN2O
5-Amino-2-(4-chloro-benzyl)-pyrimidine-4,6-diol chemical structure, C11H10ClN3O2, CAS 1204762-15-1
5-Amino-2-(4-chloro-benzyl)-pyrimidine-4,6-diol
CAS 1204762-15-1C11H10ClN3O2
5-Pyrimidineacetic acid, 6-hydroxy-2-(4-isopropoxybenzyl)-4-methyl- chemical structure, C17H20N2O4, CAS 64677-97-0
5-Pyrimidineacetic acid, 6-hydroxy-2-(4-isopropoxybenzyl)-4-methyl-
CAS 64677-97-0C17H20N2O4
2-Benzyl-6-methyl-4(3H)-pyrimidinone chemical structure, C12H12N2O, CAS 16673-85-1
2-Benzyl-6-methyl-4(3H)-pyrimidinone
CAS 16673-85-1C12H12N2O
5-Pyrimidineacetic acid, 4-hydroxy-2-(p-isopropoxybenzyl)-6-methyl-, ethyl ester chemical structure, C19H24N2O4, CAS 64678-02-0
5-Pyrimidineacetic acid, 4-hydroxy-2-(p-isopropoxybenzyl)-6-methyl-, ethyl ester
CAS 64678-02-0C19H24N2O4