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Murcko scaffold

Ring system with 4 rings and 23 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
16
With full pages
8
Scaffold SMILES

O=C1CC(c2ccccc2)CC2=C1C(c1ccccc1)C=CO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)CC2=C1C(c1ccccc1)C=CO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

2-Amino-4-(4-methoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile chemical structure, C23H20N2O3, CAS 5283-04-5
2-Amino-4-(4-methoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
CAS 5283-04-5C23H20N2O3
2-Amino-4-(4-methylsulfanylphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile chemical structure, C23H20N2O2S, CAS 331856-35-0
2-Amino-4-(4-methylsulfanylphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
CAS 331856-35-0C23H20N2O2S
2-Amino-4-(2-fluorophenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile chemical structure, C22H17FN2O2, CAS 311326-53-1
2-Amino-4-(2-fluorophenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
CAS 311326-53-1C22H17FN2O2
2-Amino-4-(3-methoxyphenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile chemical structure, C23H20N2O3, CAS 331856-58-7
2-Amino-4-(3-methoxyphenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CAS 331856-58-7C23H20N2O3
2-Amino-4-(3-bromo-4-methoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile chemical structure, C23H19BrN2O3, CAS 331856-66-7
2-Amino-4-(3-bromo-4-methoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
CAS 331856-66-7C23H19BrN2O3
2-Amino-4-(4-nitrophenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile chemical structure, C22H17N3O4, CAS 5275-37-6
2-Amino-4-(4-nitrophenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
CAS 5275-37-6C22H17N3O4
2-Amino-4-(4-bromophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile chemical structure, C22H17BrN2O2, CAS 311326-57-5
2-Amino-4-(4-bromophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CAS 311326-57-5C22H17BrN2O2
2-Amino-4-(2,4-dichlorophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile chemical structure, C22H16Cl2N2O2, CAS 331856-98-5
2-Amino-4-(2,4-dichlorophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CAS 331856-98-5C22H16Cl2N2O2
2-Amino-4-(3-fluorophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile chemical structure, C22H17FN2O2, CAS 311326-55-3
2-Amino-4-(3-fluorophenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CAS 311326-55-3C22H17FN2O2
2-Amino-4-(2,5-dimethoxyphenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile chemical structure, C24H22N2O4, CAS 362488-13-9
2-Amino-4-(2,5-dimethoxyphenyl)-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CAS 362488-13-9C24H22N2O4
2-Amino-4-(5-bromo-2,4-dimethoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile chemical structure, C24H21BrN2O4, CAS 331857-31-9
2-Amino-4-(5-bromo-2,4-dimethoxyphenyl)-5-oxo-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
CAS 331857-31-9C24H21BrN2O4
Ethyl 2-amino-4,7-bis(2-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate chemical structure, C24H21Cl2NO4, CAS 312697-86-2
Ethyl 2-amino-4,7-bis(2-chlorophenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate
CAS 312697-86-2C24H21Cl2NO4
Methyl 4-(2-amino-3-cyano-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromen-4-yl)benzoate chemical structure, C24H20N2O4, CAS 501915-31-7
Methyl 4-(2-amino-3-cyano-5-oxo-7-phenyl-5,6,7,8-tetrahydro-4H-chromen-4-yl)benzoate
CAS 501915-31-7C24H20N2O4
2-Amino-7-(3-chlorophenyl)-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile chemical structure, C22H17ClN2O2, CAS 351165-07-6
2-Amino-7-(3-chlorophenyl)-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CAS 351165-07-6C22H17ClN2O2
2-Amino-4-(4-methoxyphenyl)-7-(4-methylphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile chemical structure, C24H22N2O3, CAS 303205-99-4
2-Amino-4-(4-methoxyphenyl)-7-(4-methylphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile
CAS 303205-99-4C24H22N2O3
Ethyl 2-amino-4-(2-chlorophenyl)-5,6,7,8-tetrahydro-5-oxo-7-phenyl-4H-1-benzopyran-3-carboxylate chemical structure, C24H22ClNO4, CAS 362488-43-5
Ethyl 2-amino-4-(2-chlorophenyl)-5,6,7,8-tetrahydro-5-oxo-7-phenyl-4H-1-benzopyran-3-carboxylate
CAS 362488-43-5C24H22ClNO4