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Murcko scaffold

4,7-Diphenyl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione scaffold

87 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
87
With full pages
5
Scaffold SMILES

O=C1CC(c2ccccc2)C2=C(CC(c3ccccc3)CC2=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4,7-Diphenyl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione page
Murcko scaffold O=C1CC(c2ccccc2)C2=C(CC(c3ccccc3)CC2=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 87 chemicals

4,7-Diphenyl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C21H19NO2, CAS 372171-83-0
4,7-Diphenyl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 372171-83-0C21H19NO2
4-(2-Chlorophenyl)-7-(4-ethoxy-3-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C24H24ClNO4, CAS 832105-83-6
4-(2-Chlorophenyl)-7-(4-ethoxy-3-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 832105-83-6C24H24ClNO4
4-(4-Methyl-3-nitrophenyl)-7-phenyl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C22H20N2O4, CAS 832118-94-2
4-(4-Methyl-3-nitrophenyl)-7-phenyl-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 832118-94-2C22H20N2O4
Ethyl 4-(2,3-dimethoxyphenyl)-2,5-dioxo-7-phenyl-1,2,3,4,5,6,7,8-octahydroquinoline-6-carboxylate chemical structure, C26H27NO6, CAS 1005282-02-9
Ethyl 4-(2,3-dimethoxyphenyl)-2,5-dioxo-7-phenyl-1,2,3,4,5,6,7,8-octahydroquinoline-6-carboxylate
CAS 1005282-02-9C26H27NO6
7-(3,4-Dimethoxyphenyl)-4-(3-hydroxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C23H23NO5, CAS 878445-06-8
7-(3,4-Dimethoxyphenyl)-4-(3-hydroxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 878445-06-8C23H23NO5
7-(2,5-Dimethoxyphenyl)-4-(3,4-dimethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C25H27NO6, CAS 878445-35-3
7-(2,5-Dimethoxyphenyl)-4-(3,4-dimethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 878445-35-3C25H27NO6
7-(3,4-Dimethoxyphenyl)-4-(2-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C24H25NO5, CAS 878446-09-4
7-(3,4-Dimethoxyphenyl)-4-(2-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 878446-09-4C24H25NO5
4-(3,4-Dimethoxyphenyl)-7-(4-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C24H25NO5, CAS 878446-39-0
4-(3,4-Dimethoxyphenyl)-7-(4-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 878446-39-0C24H25NO5
7-(2,5-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C23H22FNO4, CAS 878446-45-8
7-(2,5-Dimethoxyphenyl)-4-(2-fluorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 878446-45-8C23H22FNO4
4-(4-Hydroxy-3-methoxyphenyl)-7-(4-methylphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C23H23NO4, CAS 879044-01-6
4-(4-Hydroxy-3-methoxyphenyl)-7-(4-methylphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879044-01-6C23H23NO4
4-(3,4-Dimethoxyphenyl)-7-(4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C26H29NO5, CAS 879044-30-1
4-(3,4-Dimethoxyphenyl)-7-(4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879044-30-1C26H29NO5
4-(3-Chloro-5-ethoxy-4-hydroxyphenyl)-7-(4-ethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C25H26ClNO5, CAS 879044-44-7
4-(3-Chloro-5-ethoxy-4-hydroxyphenyl)-7-(4-ethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879044-44-7C25H26ClNO5
4-(3-Hydroxyphenyl)-7-(3-methoxy-4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C25H27NO5, CAS 879044-53-8
4-(3-Hydroxyphenyl)-7-(3-methoxy-4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879044-53-8C25H27NO5
7-(4-tert-Butylphenyl)-4-(4-hydroxy-3-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C26H29NO4, CAS 879044-94-7
7-(4-tert-Butylphenyl)-4-(4-hydroxy-3-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879044-94-7C26H29NO4
4-(4-Hydroxy-3,5-dimethoxyphenyl)-7-(4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C26H29NO6, CAS 879045-51-9
4-(4-Hydroxy-3,5-dimethoxyphenyl)-7-(4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879045-51-9C26H29NO6
4-(2-Chlorophenyl)-7-(3-methoxy-4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C25H26ClNO4, CAS 879046-32-9
4-(2-Chlorophenyl)-7-(3-methoxy-4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879046-32-9C25H26ClNO4
7-(4-tert-Butylphenyl)-4-(2-ethoxy-3-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C28H33NO4, CAS 879046-79-4
7-(4-tert-Butylphenyl)-4-(2-ethoxy-3-methoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879046-79-4C28H33NO4
7-(4-tert-Butylphenyl)-4-(2,3,4-trimethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione chemical structure, C28H33NO5, CAS 879047-45-7
7-(4-tert-Butylphenyl)-4-(2,3,4-trimethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
CAS 879047-45-7C28H33NO5
4-(4-Hydroxyphenyl)-7-(3-methoxy-4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C25H27NO5, CAS 879047-75-3
4-(4-Hydroxyphenyl)-7-(3-methoxy-4-propan-2-yloxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 879047-75-3C25H27NO5
4-(4-Methoxyphenyl)-7-(3,4,5-trimethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione chemical structure, C25H27NO6, CAS 879047-81-1
4-(4-Methoxyphenyl)-7-(3,4,5-trimethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
CAS 879047-81-1C25H27NO6
4-(3-Fluorophenyl)-7-(4-fluorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C21H17F2NO2, CAS 847510-09-2
4-(3-Fluorophenyl)-7-(4-fluorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 847510-09-2C21H17F2NO2
4-(2-Fluorophenyl)-7-(4-fluorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione chemical structure, C21H17F2NO2, CAS 847510-10-5
4-(2-Fluorophenyl)-7-(4-fluorophenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione
CAS 847510-10-5C21H17F2NO2
7-(2-Chlorophenyl)-4-(2-methoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione chemical structure, C22H20ClNO3, CAS 886632-16-2
7-(2-Chlorophenyl)-4-(2-methoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
CAS 886632-16-2C22H20ClNO3
7-(4-Fluorophenyl)-4-(4-methoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione chemical structure, C22H20FNO3, CAS 886626-86-4
7-(4-Fluorophenyl)-4-(4-methoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
CAS 886626-86-4C22H20FNO3