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Murcko scaffold

Ring system with 4 rings and 22 atoms

14 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
14
With full pages
1
Scaffold SMILES

c1ccc(-c2ccc3c(N4CCNCC4)ncnc3c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ccc3c(N4CCNCC4)ncnc3c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

tert-Butyl 4-(6-chloro-8-fluoro-7-(2-fluoro-6-methoxyphenyl)quinazolin-4-yl)piperazine-1-carboxylate chemical structure, C24H25ClF2N4O3, CAS 1698027-21-2
tert-Butyl 4-(6-chloro-8-fluoro-7-(2-fluoro-6-methoxyphenyl)quinazolin-4-yl)piperazine-1-carboxylate
CAS 1698027-21-2C24H25ClF2N4O3
1-[4-(6-Chloro-7-phenyl-4-quinazolinyl)-1-piperazinyl]-2-propen-1-one chemical structure, C21H19ClN4O, CAS 1698023-01-6
1-[4-(6-Chloro-7-phenyl-4-quinazolinyl)-1-piperazinyl]-2-propen-1-one
CAS 1698023-01-6C21H19ClN4O
1-(4-(6-Chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one chemical structure, C21H18ClFN4O, CAS 1698023-15-2
1-(4-(6-Chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
CAS 1698023-15-2C21H18ClFN4O
1-[4-[6-Chloro-7-(2-methoxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one chemical structure, C22H21ClN4O2, CAS 1698023-31-2
1-[4-[6-Chloro-7-(2-methoxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
CAS 1698023-31-2C22H21ClN4O2
tert-Butyl 4-(6-chloro-7-phenylquinazolin-4-yl)piperazine-1-carboxylate chemical structure, C23H25ClN4O2, CAS 1698027-01-8
tert-Butyl 4-(6-chloro-7-phenylquinazolin-4-yl)piperazine-1-carboxylate
CAS 1698027-01-8C23H25ClN4O2
1-[4-[6-Chloro-7-(2-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one chemical structure, C21H19ClN4O2, CAS 1698023-08-3
1-[4-[6-Chloro-7-(2-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
CAS 1698023-08-3C21H19ClN4O2
2-(4-(4-Acryloylpiperazin-1-yl)-6-chloroquinazolin-7-yl)-3-hydroxybenzonitrile chemical structure, C22H18ClN5O2, CAS 1698025-12-5
2-(4-(4-Acryloylpiperazin-1-yl)-6-chloroquinazolin-7-yl)-3-hydroxybenzonitrile
CAS 1698025-12-5C22H18ClN5O2
Ars-1620 chemical structure, C21H17ClF2N4O2, CAS 1698055-85-4
Ars-1620
CAS 1698055-85-4C21H17ClF2N4O2
KRAS inhibitor-6 chemical structure, C27H30ClF2N5O3, CAS 2022986-61-2
KRAS inhibitor-6
CAS 2022986-61-2C27H30ClF2N5O3
ARS-1323-alkyne chemical structure, C28H27ClF2N6O3, CAS 2436544-27-1
ARS-1323-alkyne
CAS 2436544-27-1C28H27ClF2N6O3
tert-Butyl 4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazine-1-carboxylate chemical structure, C23H23ClF2N4O3, CAS 2223023-61-6
tert-Butyl 4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazine-1-carboxylate
CAS 2223023-61-6C23H23ClF2N4O3
1-(4-(2-(But-3-YN-1-ylamino)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-EN-1-one chemical structure, C25H22ClF2N5O2, CAS 2231084-05-0
1-(4-(2-(But-3-YN-1-ylamino)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-EN-1-one
CAS 2231084-05-0C25H22ClF2N5O2
1-[4-[6-Chloro-7-(5-chloro-2-methoxyphenyl)-8-fluoroquinazolin-4-yl]-3-methylpiperazin-1-yl]-2-(trifluoromethyl)prop-2-en-1-one chemical structure, C24H20Cl2F4N4O2, CAS 2915618-92-5
1-[4-[6-Chloro-7-(5-chloro-2-methoxyphenyl)-8-fluoroquinazolin-4-yl]-3-methylpiperazin-1-yl]-2-(trifluoromethyl)prop-2-en-1-one
CAS 2915618-92-5C24H20Cl2F4N4O2
tert-Butyl 4-(6-chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazine-1-carboxylate chemical structure, C23H24ClFN4O2, CAS 2223027-88-9
tert-Butyl 4-(6-chloro-7-(2-fluorophenyl)quinazolin-4-yl)piperazine-1-carboxylate
CAS 2223027-88-9C23H24ClFN4O2