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Murcko scaffold

Ring system with 2 rings and 16 atoms

74 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
74
With full pages
10
Scaffold SMILES

O=C(C=Cc1ccccc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 74 chemicals

Ethyl {4-[3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]piperazin-1-yl}acetate chemical structure, C20H29ClN2O6
Ethyl {4-[3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]piperazin-1-yl}acetate
C20H29ClN2O6
4-[3-(4-Methylpiperazino)-3-oxo-1-propenyl]benzenecarbonitrile chemical structure, C15H17N3O, CAS 298215-49-3
4-[3-(4-Methylpiperazino)-3-oxo-1-propenyl]benzenecarbonitrile
CAS 298215-49-3C15H17N3O
3-(4-Isopropylphenyl)-1-(4-methylpiperazin-1-yl)prop-2-en-1-one chemical structure, C17H24N2O, CAS 414885-66-8
3-(4-Isopropylphenyl)-1-(4-methylpiperazin-1-yl)prop-2-en-1-one
CAS 414885-66-8C17H24N2O
(E)-1-(4-Ethylpiperazin-1-yl)-3-(3-nitrophenyl)prop-2-en-1-one chemical structure, C15H19N3O3, CAS 432529-28-7
(E)-1-(4-Ethylpiperazin-1-yl)-3-(3-nitrophenyl)prop-2-en-1-one
CAS 432529-28-7C15H19N3O3
3-(4-Chloro-phenyl)-1-(4-methyl-piperazin-1-yl)-propenone chemical structure, C14H17ClN2O, CAS 92294-56-9
3-(4-Chloro-phenyl)-1-(4-methyl-piperazin-1-yl)-propenone
CAS 92294-56-9C14H17ClN2O
(E)-1-(4-Methylpiperazin-1-yl)-3-(4-nitrophenyl)prop-2-en-1-one chemical structure, C14H17N3O3, CAS 1164483-02-6
(E)-1-(4-Methylpiperazin-1-yl)-3-(4-nitrophenyl)prop-2-en-1-one
CAS 1164483-02-6C14H17N3O3
(E)-1-(4-Ethylpiperazin-1-yl)-3-(2-nitrophenyl)prop-2-en-1-one chemical structure, C15H19N3O3, CAS 600123-99-7
(E)-1-(4-Ethylpiperazin-1-yl)-3-(2-nitrophenyl)prop-2-en-1-one
CAS 600123-99-7C15H19N3O3
(E)-1-(4-Methylpiperazin-1-yl)-3-(2-nitrophenyl)prop-2-en-1-one chemical structure, C14H17N3O3, CAS 600123-45-3
(E)-1-(4-Methylpiperazin-1-yl)-3-(2-nitrophenyl)prop-2-en-1-one
CAS 600123-45-3C14H17N3O3
1-Ethyl-4-[3-(4-fluorophenyl)acryloyl]piperazine chemical structure, C15H19FN2O, CAS 545371-07-1
1-Ethyl-4-[3-(4-fluorophenyl)acryloyl]piperazine
CAS 545371-07-1C15H19FN2O
1-[3-(4-Chlorophenyl)acryloyl]-4-methylpiperazine chemical structure, C14H17ClN2O, CAS 1164473-11-3
1-[3-(4-Chlorophenyl)acryloyl]-4-methylpiperazine
CAS 1164473-11-3C14H17ClN2O
1-Ethyl-4-[3-(4-isopropylphenyl)acryloyl]piperazine chemical structure, C18H26N2O, CAS 546063-22-3
1-Ethyl-4-[3-(4-isopropylphenyl)acryloyl]piperazine
CAS 546063-22-3C18H26N2O
3-[4-(Difluoromethoxy)phenyl]-2-(4-methylpiperazine-1-carbonyl)prop-2-enenitrile chemical structure, C16H17F2N3O2, CAS 326178-00-1
3-[4-(Difluoromethoxy)phenyl]-2-(4-methylpiperazine-1-carbonyl)prop-2-enenitrile
CAS 326178-00-1C16H17F2N3O2
3-[4-(Difluoromethoxy)phenyl]-2-(4-ethylpiperazine-1-carbonyl)prop-2-enenitrile chemical structure, C17H19F2N3O2, CAS 768349-11-7
3-[4-(Difluoromethoxy)phenyl]-2-(4-ethylpiperazine-1-carbonyl)prop-2-enenitrile
CAS 768349-11-7C17H19F2N3O2
3-(4-Fluorophenyl)-2-(4-methylpiperazine-1-carbonyl)prop-2-enenitrile chemical structure, C15H16FN3O, CAS 306275-85-4
3-(4-Fluorophenyl)-2-(4-methylpiperazine-1-carbonyl)prop-2-enenitrile
CAS 306275-85-4C15H16FN3O
2-(4-Acetylpiperazine-1-carbonyl)-3-phenylprop-2-enenitrile chemical structure, C16H17N3O2, CAS 464221-85-0
2-(4-Acetylpiperazine-1-carbonyl)-3-phenylprop-2-enenitrile
CAS 464221-85-0C16H17N3O2
1-Cinnamoylpiperazine chemical structure, C13H16N2O, CAS 55486-27-6
1-Cinnamoylpiperazine
CAS 55486-27-6C13H16N2O
(E)-3-(4,5-Dimethoxy-2-nitrophenyl)-1-(4-methylpiperazino)-2-propen-1-one chemical structure, C16H21N3O5, CAS 331461-82-6
(E)-3-(4,5-Dimethoxy-2-nitrophenyl)-1-(4-methylpiperazino)-2-propen-1-one
CAS 331461-82-6C16H21N3O5
4-[(E)-3-(3,4-Dichlorophenyl)prop-2-enoyl]piperazine-1-carbaldehyde chemical structure, C14H14Cl2N2O2, CAS 1025311-59-4
4-[(E)-3-(3,4-Dichlorophenyl)prop-2-enoyl]piperazine-1-carbaldehyde
CAS 1025311-59-4C14H14Cl2N2O2
1-Piperazineacetamide, 4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (E)- chemical structure, C18H25N3O5, CAS 88052-15-7
1-Piperazineacetamide, 4-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-, (E)-
CAS 88052-15-7C18H25N3O5
Piperazine, 4-methyl-1-(m-(trifluoromethyl)cinnamoyl)- chemical structure, C15H17F3N2O, CAS 93040-64-3
Piperazine, 4-methyl-1-(m-(trifluoromethyl)cinnamoyl)-
CAS 93040-64-3C15H17F3N2O
Cinepazet maleate chemical structure, C24H32N2O10, CAS 50679-07-7
Cinepazet maleate
CAS 50679-07-7C24H32N2O10
Cinepazet chemical structure, C20H28N2O6, CAS 23887-41-4
Cinepazet
CAS 23887-41-4C20H28N2O6
Cinpropazide chemical structure, C21H31N3O5, CAS 23887-47-0
Cinpropazide
CAS 23887-47-0C21H31N3O5
Piperazine, 1-methyl-4-(3,4,5-trimethoxycinnamoyl)- chemical structure, C17H24N2O4, CAS 1703-36-2
Piperazine, 1-methyl-4-(3,4,5-trimethoxycinnamoyl)-
CAS 1703-36-2C17H24N2O4