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Murcko scaffold

2',3',5',6'-Tetrahydrospiro[indoline-3,4'-pyran]-2-one scaffold

37 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
37
With full pages
2
Scaffold SMILES

O=C1Nc2ccccc2C12CCOCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2',3',5',6'-Tetrahydrospiro[indoline-3,4'-pyran]-2-one page
Murcko scaffold O=C1Nc2ccccc2C12CCOCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

2',3',5',6'-Tetrahydrospiro[indoline-3,4'-pyran]-2-one chemical structure, C12H13NO2, CAS 304876-29-7
2',3',5',6'-Tetrahydrospiro[indoline-3,4'-pyran]-2-one
CAS 304876-29-7C12H13NO2
5-Bromo-1,2-dihydrospiro(indole-3,4'-oxane)-2-one chemical structure, C12H12BrNO2, CAS 304876-31-1
5-Bromo-1,2-dihydrospiro(indole-3,4'-oxane)-2-one
CAS 304876-31-1C12H12BrNO2
tert-Butyl 6-bromo-2-oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylate chemical structure, C17H20BrNO4, CAS 1190861-47-2
tert-Butyl 6-bromo-2-oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-carboxylate
CAS 1190861-47-2C17H20BrNO4
2-(2-Oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-yl)acetic acid chemical structure, C14H15NO4, CAS 880079-26-5
2-(2-Oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-1-yl)acetic acid
CAS 880079-26-5C14H15NO4
6-Bromo-1,2-dihydrospiro[indole-3,4'-oxane]-2-one chemical structure, C12H12BrNO2, CAS 1190861-43-8
6-Bromo-1,2-dihydrospiro[indole-3,4'-oxane]-2-one
CAS 1190861-43-8C12H12BrNO2
6-Methyl-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C13H15NO2, CAS 2167124-53-8
6-Methyl-1H-spiro[indole-3,4'-oxane]-2-one
CAS 2167124-53-8C13H15NO2
5-Nitro-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one chemical structure, C12H12N2O4, CAS 1263182-11-1
5-Nitro-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one
CAS 1263182-11-1C12H12N2O4
2-Oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-5-carboxylic acid chemical structure, C13H13NO4, CAS 1373028-72-8
2-Oxo-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-5-carboxylic acid
CAS 1373028-72-8C13H13NO4
5-Amino-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one chemical structure, C12H14N2O2, CAS 1251021-08-5
5-Amino-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one
CAS 1251021-08-5C12H14N2O2
5-Fluoro-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C12H12FNO2, CAS 1603067-38-4
5-Fluoro-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1603067-38-4C12H12FNO2
4-Fluorospiro[1H-indole-3,4'-oxane]-2-one chemical structure, C12H12FNO2, CAS 1603067-39-5
4-Fluorospiro[1H-indole-3,4'-oxane]-2-one
CAS 1603067-39-5C12H12FNO2
5-Amino-1-isopropyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one chemical structure, C15H20N2O2, CAS 1422134-58-4
5-Amino-1-isopropyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one
CAS 1422134-58-4C15H20N2O2
5-Chloro-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C12H12ClNO2, CAS 156232-36-9
5-Chloro-1H-spiro[indole-3,4'-oxane]-2-one
CAS 156232-36-9C12H12ClNO2
7-Fluoro-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C12H12FNO2, CAS 1695305-20-4
7-Fluoro-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1695305-20-4C12H12FNO2
7-Methoxy-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C13H15NO3, CAS 1976265-58-3
7-Methoxy-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1976265-58-3C13H15NO3
7-(Trifluoromethyl)-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C13H12F3NO2, CAS 1978002-11-7
7-(Trifluoromethyl)-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1978002-11-7C13H12F3NO2
7-Methyl-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C13H15NO2, CAS 1697929-45-5
7-Methyl-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1697929-45-5C13H15NO2
7-Chloro-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C12H12ClNO2, CAS 1694218-82-0
7-Chloro-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1694218-82-0C12H12ClNO2
7-Bromo-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C12H12BrNO2, CAS 1694132-58-5
7-Bromo-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1694132-58-5C12H12BrNO2
5-Methoxy-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C13H15NO3, CAS 1979811-64-7
5-Methoxy-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1979811-64-7C13H15NO3
5-(Trifluoromethyl)-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C13H12F3NO2, CAS 1968119-40-5
5-(Trifluoromethyl)-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1968119-40-5C13H12F3NO2
5-Methyl-1H-spiro[indole-3,4'-oxane]-2-one chemical structure, C13H15NO2, CAS 1693858-46-6
5-Methyl-1H-spiro[indole-3,4'-oxane]-2-one
CAS 1693858-46-6C13H15NO2
5-Amino-1-ethyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one chemical structure, C14H18N2O2, CAS 1422069-45-1
5-Amino-1-ethyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one
CAS 1422069-45-1C14H18N2O2
1-Allyl-5-amino-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one chemical structure, C15H18N2O2, CAS 1422065-87-9
1-Allyl-5-amino-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one
CAS 1422065-87-9C15H18N2O2