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Murcko scaffold

Ring system with 3 rings and 15 atoms

76 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
76
With full pages
9
Scaffold SMILES

O=C1Nc2ccccc2C12C=COC=C2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C12C=COC=C2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 76 chemicals

Prop-2-enyl 6'-amino-5'-cyano-2'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3'-carboxylate chemical structure, C18H15N3O4, CAS 313381-58-7
Prop-2-enyl 6'-amino-5'-cyano-2'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3'-carboxylate
CAS 313381-58-7C18H15N3O4
Ethyl 2'-amino-3'-cyano-5-methyl-2-oxo-6'-propylspiro[indoline-3,4'-pyran]-5'-carboxylate chemical structure, C20H21N3O4, CAS 300731-75-3
Ethyl 2'-amino-3'-cyano-5-methyl-2-oxo-6'-propylspiro[indoline-3,4'-pyran]-5'-carboxylate
CAS 300731-75-3C20H21N3O4
Methyl 6'-amino-5'-cyano-2'-(2-methoxy-2-oxoethyl)-1-methyl-2-oxospiro[indole-3,4'-pyran]-3'-carboxylate chemical structure, C19H17N3O6, CAS 445222-65-1
Methyl 6'-amino-5'-cyano-2'-(2-methoxy-2-oxoethyl)-1-methyl-2-oxospiro[indole-3,4'-pyran]-3'-carboxylate
CAS 445222-65-1C19H17N3O6
Diethyl 2'-amino-5-bromo-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C19H19BrN2O6, CAS 327100-82-3
Diethyl 2'-amino-5-bromo-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate
CAS 327100-82-3C19H19BrN2O6
2'-Amino-5'-carboxylic acidethylester-3'-cyano-6'-phenyl-spiro-(indol-3,4'-pyranen) chemical structure, C19H19N3O4, CAS 119771-48-1
2'-Amino-5'-carboxylic acidethylester-3'-cyano-6'-phenyl-spiro-(indol-3,4'-pyranen)
CAS 119771-48-1C19H19N3O4
RefChem:382291 chemical structure, C17H15N3O4, CAS 5192-73-4
RefChem:382291
CAS 5192-73-4C17H15N3O4
Ethyl 5'-acetyl-2'-amino-6'-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3'-carboxylate chemical structure, C18H18N2O5, CAS 74647-44-2
Ethyl 5'-acetyl-2'-amino-6'-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3'-carboxylate
CAS 74647-44-2C18H18N2O5
5'-Acetyl-2'-amino-5-bromo-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3'-carbonitrile chemical structure, C16H12BrN3O3, CAS 313381-97-4
5'-Acetyl-2'-amino-5-bromo-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3'-carbonitrile
CAS 313381-97-4C16H12BrN3O3
Ethyl 2'-amino-5-bromo-3'-cyano-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate chemical structure, C17H14BrN3O4, CAS 331950-47-1
Ethyl 2'-amino-5-bromo-3'-cyano-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate
CAS 331950-47-1C17H14BrN3O4
Ethyl 2'-amino-3'-cyano-2-oxo-6'-propylspiro[indoline-3,4'-pyran]-5'-carboxylate chemical structure, C19H19N3O4, CAS 302796-61-8
Ethyl 2'-amino-3'-cyano-2-oxo-6'-propylspiro[indoline-3,4'-pyran]-5'-carboxylate
CAS 302796-61-8C19H19N3O4
5'-Allyl 3'-tert-butyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C22H24N2O6, CAS 336180-98-4
5'-Allyl 3'-tert-butyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate
CAS 336180-98-4C22H24N2O6
Ethyl 6'-amino-5'-cyano-2'-methyl-5-nitro-2-oxospiro[1H-indole-3,4'-pyran]-3'-carboxylate chemical structure, C17H14N4O6, CAS 311333-50-3
Ethyl 6'-amino-5'-cyano-2'-methyl-5-nitro-2-oxospiro[1H-indole-3,4'-pyran]-3'-carboxylate
CAS 311333-50-3C17H14N4O6
Methyl 2'-amino-3'-cyano-6'-methyl-5-nitro-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate chemical structure, C16H12N4O6, CAS 304870-90-4
Methyl 2'-amino-3'-cyano-6'-methyl-5-nitro-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate
CAS 304870-90-4C16H12N4O6
Prop-2-enyl 6'-amino-5'-cyano-2'-methyl-5-nitro-2-oxospiro[1H-indole-3,4'-pyran]-3'-carboxylate chemical structure, C18H14N4O6, CAS 311333-51-4
Prop-2-enyl 6'-amino-5'-cyano-2'-methyl-5-nitro-2-oxospiro[1H-indole-3,4'-pyran]-3'-carboxylate
CAS 311333-51-4C18H14N4O6
3'-tert-Butyl 5'-ethyl 2'-amino-2-oxo-6'-propylspiro[indoline-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C23H28N2O6, CAS 313381-64-5
3'-tert-Butyl 5'-ethyl 2'-amino-2-oxo-6'-propylspiro[indoline-3,4'-pyran]-3',5'-dicarboxylate
CAS 313381-64-5C23H28N2O6
3'-tert-Butyl 5'-isopropyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C22H26N2O6, CAS 300732-10-9
3'-tert-Butyl 5'-isopropyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate
CAS 300732-10-9C22H26N2O6
3',5'-Dimethyl 6'-amino-2'-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C17H16N2O6, CAS 401461-50-5
3',5'-Dimethyl 6'-amino-2'-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3',5'-dicarboxylate
CAS 401461-50-5C17H16N2O6
5'-Acetyl-2'-amino-6'-methyl-5-nitro-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3'-carbonitrile chemical structure, C16H12N4O5, CAS 300588-88-9
5'-Acetyl-2'-amino-6'-methyl-5-nitro-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3'-carbonitrile
CAS 300588-88-9C16H12N4O5
5-O'-Ethyl 3-O'-methyl 2'-amino-2-oxo-6'-propylspiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C20H22N2O6, CAS 313381-63-4
5-O'-Ethyl 3-O'-methyl 2'-amino-2-oxo-6'-propylspiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate
CAS 313381-63-4C20H22N2O6
5'-tert-Butyl 3'-methyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C20H22N2O6, CAS 300804-77-7
5'-tert-Butyl 3'-methyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate
CAS 300804-77-7C20H22N2O6
3'-tert-Butyl 5'-methyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C20H22N2O6, CAS 304869-64-5
3'-tert-Butyl 5'-methyl 2'-amino-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-3',5'-dicarboxylate
CAS 304869-64-5C20H22N2O6
3-O'-(2-Methoxyethyl) 5-O'-propan-2-yl 2'-amino-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C21H24N2O7, CAS 313381-70-3
3-O'-(2-Methoxyethyl) 5-O'-propan-2-yl 2'-amino-6'-methyl-2-oxospiro[1H-indole-3,4'-pyran]-3',5'-dicarboxylate
CAS 313381-70-3C21H24N2O7
Isopropyl 2'-amino-3'-cyano-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate chemical structure, C18H17N3O4, CAS 300731-21-9
Isopropyl 2'-amino-3'-cyano-6'-methyl-2-oxospiro[indoline-3,4'-pyran]-5'-carboxylate
CAS 300731-21-9C18H17N3O4
5'-tert-Butyl 3'-ethyl 2'-amino-6'-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3',5'-dicarboxylate chemical structure, C21H24N2O6, CAS 304869-96-3
5'-tert-Butyl 3'-ethyl 2'-amino-6'-methyl-2-oxo-1,2-dihydrospiro[indole-3,4'-pyran]-3',5'-dicarboxylate
CAS 304869-96-3C21H24N2O6