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Murcko scaffold

Spiro[cyclohexane-1,3'-indolin]-2'-one scaffold

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
18
With full pages
3
Scaffold SMILES

O=C1Nc2ccccc2C12CCCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro[cyclohexane-1,3'-indolin]-2'-one page
Murcko scaffold O=C1Nc2ccccc2C12CCCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

5'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one chemical structure, C13H14BrNO, CAS 304468-42-6
5'-Bromo-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-2'-one
CAS 304468-42-6C13H14BrNO
Spiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H15NO, CAS 4933-14-6
Spiro[cyclohexane-1,3'-indolin]-2'-one
CAS 4933-14-6C13H15NO
5'-Amino-spiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H16N2O, CAS 156232-57-4
5'-Amino-spiro[cyclohexane-1,3'-indolin]-2'-one
CAS 156232-57-4C13H16N2O
6'-Bromospiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H14BrNO, CAS 1190866-02-4
6'-Bromospiro[cyclohexane-1,3'-indolin]-2'-one
CAS 1190866-02-4C13H14BrNO
5'-Nitrospiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H14N2O3, CAS 156232-54-1
5'-Nitrospiro[cyclohexane-1,3'-indolin]-2'-one
CAS 156232-54-1C13H14N2O3
6'-Chlorospiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H14ClNO, CAS 156232-20-1
6'-Chlorospiro[cyclohexane-1,3'-indolin]-2'-one
CAS 156232-20-1C13H14ClNO
5'-Hydroxyspiro[cyclohexane-1,3'-indol]-2'(1'H)-one chemical structure, C13H15NO2, CAS 930790-76-4
5'-Hydroxyspiro[cyclohexane-1,3'-indol]-2'(1'H)-one
CAS 930790-76-4C13H15NO2
4'-Chlorospiro[cyclohexane-1,3'-indol]-2'(1'H)-one chemical structure, C13H14ClNO, CAS 156232-37-0
4'-Chlorospiro[cyclohexane-1,3'-indol]-2'(1'H)-one
CAS 156232-37-0C13H14ClNO
(6'-Bromo-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl)acetic acid chemical structure, C15H16BrNO3, CAS 1782417-57-5
(6'-Bromo-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl)acetic acid
CAS 1782417-57-5C15H16BrNO3
(1S,2R)-1'-Methyl-2'-oxospiro[cyclohexane-2,3'-indole]-1-carbonitrile chemical structure, C15H16N2O, CAS 947184-94-3
(1S,2R)-1'-Methyl-2'-oxospiro[cyclohexane-2,3'-indole]-1-carbonitrile
CAS 947184-94-3C15H16N2O
5'-Ethoxy-4-(methoxymethoxy)spiro[cyclohexane-1,3'-[3H]indol]-2'(1'H)-one chemical structure, C17H23NO4, CAS 161919-83-1
5'-Ethoxy-4-(methoxymethoxy)spiro[cyclohexane-1,3'-[3H]indol]-2'(1'H)-one
CAS 161919-83-1C17H23NO4
1,1-Dimethyl-3-(2'-oxospiro[cyclohexane-1,3'-indolin]-5'-yl)urea chemical structure, C16H21N3O2, CAS 1327149-89-2
1,1-Dimethyl-3-(2'-oxospiro[cyclohexane-1,3'-indolin]-5'-yl)urea
CAS 1327149-89-2C16H21N3O2
1,1-Diethyl-3-(2'-oxospiro[cyclohexane-1,3'-indolin]-5'-yl)urea chemical structure, C18H25N3O2, CAS 1326731-41-2
1,1-Diethyl-3-(2'-oxospiro[cyclohexane-1,3'-indolin]-5'-yl)urea
CAS 1326731-41-2C18H25N3O2
1-(2'-Oxospiro[cyclohexane-1,3'-indolin]-5'-yl)-3-propylurea chemical structure, C17H23N3O2, CAS 1326761-68-5
1-(2'-Oxospiro[cyclohexane-1,3'-indolin]-5'-yl)-3-propylurea
CAS 1326761-68-5C17H23N3O2
7'-Nitrospiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H14N2O3, CAS 1985107-08-1
7'-Nitrospiro[cyclohexane-1,3'-indolin]-2'-one
CAS 1985107-08-1C13H14N2O3
6'-Aminospiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H16N2O, CAS 2167636-50-0
6'-Aminospiro[cyclohexane-1,3'-indolin]-2'-one
CAS 2167636-50-0C13H16N2O
5'-Bromo-4-fluorospiro[cyclohexane-1,3'-indolin]-2'-one chemical structure, C13H13BrFNO, CAS 2491753-88-7
5'-Bromo-4-fluorospiro[cyclohexane-1,3'-indolin]-2'-one
CAS 2491753-88-7C13H13BrFNO
4-Bromo-4'-hydroxyspiro[1H-indole-3,1'-cyclohexane]-2-one chemical structure, C13H14BrNO2, CAS 3082236-12-9
4-Bromo-4'-hydroxyspiro[1H-indole-3,1'-cyclohexane]-2-one
CAS 3082236-12-9C13H14BrNO2