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Murcko scaffold

Spiro(indole-3,4'-piperidin)-2(1H)-one scaffold

116 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
116
With full pages
6
Scaffold SMILES

O=C1Nc2ccccc2C12CCNCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro(indole-3,4'-piperidin)-2(1H)-one page
Murcko scaffold O=C1Nc2ccccc2C12CCNCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 116 chemicals

Spiro(indoline-3,4'-piperidin)-2-one, 1'-ethyl- chemical structure, C14H18N2O, CAS 59022-55-8
Spiro(indoline-3,4'-piperidin)-2-one, 1'-ethyl-
CAS 59022-55-8C14H18N2O
Spiro(indoline-3,4'-piperidin)-2-one, 1'-ethyl-7-methyl- chemical structure, C15H20N2O, CAS 59022-56-9
Spiro(indoline-3,4'-piperidin)-2-one, 1'-ethyl-7-methyl-
CAS 59022-56-9C15H20N2O
tert-Butyl 1-methyl-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate chemical structure, C18H24N2O3, CAS 497937-62-9
tert-Butyl 1-methyl-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
CAS 497937-62-9C18H24N2O3
1'-Methylspiro[indoline-3,4'-piperidin]-2-one chemical structure, C13H16N2O, CAS 161919-72-8
1'-Methylspiro[indoline-3,4'-piperidin]-2-one
CAS 161919-72-8C13H16N2O
5-Methoxyspiro[indoline-3,4'-piperidin]-2-one chemical structure, C13H16N2O2, CAS 1258637-92-1
5-Methoxyspiro[indoline-3,4'-piperidin]-2-one
CAS 1258637-92-1C13H16N2O2
1'-Boc-1,2-dihydro-5-methoxy-2-oxo-spiro[3H-indole-3,4'-piperidine] chemical structure, C18H24N2O4, CAS 752234-64-3
1'-Boc-1,2-dihydro-5-methoxy-2-oxo-spiro[3H-indole-3,4'-piperidine]
CAS 752234-64-3C18H24N2O4
Spiro(indole-3,4'-piperidin)-2(1H)-one chemical structure, C12H14N2O, CAS 252882-61-4
Spiro(indole-3,4'-piperidin)-2(1H)-one
CAS 252882-61-4C12H14N2O
1,1'-Dimethylspiro[indole-3,4'-piperidin]-2(1H)-one chemical structure, C14H18N2O, CAS 167484-40-4
1,1'-Dimethylspiro[indole-3,4'-piperidin]-2(1H)-one
CAS 167484-40-4C14H18N2O
1'-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] chemical structure, C17H22N2O3, CAS 252882-60-3
1'-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
CAS 252882-60-3C17H22N2O3
1-Methylspiro[indoline-3,4'-piperidin]-2-one chemical structure, C13H16N2O, CAS 67677-81-0
1-Methylspiro[indoline-3,4'-piperidin]-2-one
CAS 67677-81-0C13H16N2O
1,2-Dihydrospiro[indole-3,4'-piperidine]-2-one hydrochloride chemical structure, C12H15ClN2O, CAS 356072-46-3
1,2-Dihydrospiro[indole-3,4'-piperidine]-2-one hydrochloride
CAS 356072-46-3C12H15ClN2O
tert-Butyl 5-chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate chemical structure, C17H21ClN2O3, CAS 346701-12-0
tert-Butyl 5-chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
CAS 346701-12-0C17H21ClN2O3
tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro(indole-3,4'-piperidine)-1'-carboxylate chemical structure, C17H21FN2O3, CAS 866028-06-0
tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro(indole-3,4'-piperidine)-1'-carboxylate
CAS 866028-06-0C17H21FN2O3
5-Bromo-1'-methylspiro[indoline-3,4'-piperidin]-2-one chemical structure, C13H15BrN2O, CAS 920023-48-9
5-Bromo-1'-methylspiro[indoline-3,4'-piperidin]-2-one
CAS 920023-48-9C13H15BrN2O
1'-Boc-5-Bromo-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine] chemical structure, C17H21BrN2O3, CAS 873779-30-7
1'-Boc-5-Bromo-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
CAS 873779-30-7C17H21BrN2O3
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid chemical structure, C18H22N2O5, CAS 946135-52-0
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-carboxylic acid
CAS 946135-52-0C18H22N2O5
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-ylboronic acid chemical structure, C17H23BN2O5, CAS 1246372-96-2
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]-5-ylboronic acid
CAS 1246372-96-2C17H23BN2O5
5-Chloro-1'-methylspiro[indoline-3,4'-piperidin]-2-one chemical structure, C13H15ClN2O, CAS 156232-35-8
5-Chloro-1'-methylspiro[indoline-3,4'-piperidin]-2-one
CAS 156232-35-8C13H15ClN2O
5-Fluoro-1'-methylspiro[indoline-3,4'-piperidin]-2-one chemical structure, C13H15FN2O, CAS 1198283-83-8
5-Fluoro-1'-methylspiro[indoline-3,4'-piperidin]-2-one
CAS 1198283-83-8C13H15FN2O
1'-Acetyl-6-bromospiro[indoline-3,4'-piperidin]-2-one chemical structure, C14H15BrN2O2, CAS 1160248-50-9
1'-Acetyl-6-bromospiro[indoline-3,4'-piperidin]-2-one
CAS 1160248-50-9C14H15BrN2O2
5-Methoxy-1'-methylspiro[indoline-3,4'-piperidin]-2-one chemical structure, C14H18N2O2, CAS 742067-27-2
5-Methoxy-1'-methylspiro[indoline-3,4'-piperidin]-2-one
CAS 742067-27-2C14H18N2O2
6-Bromo-1'-methylspiro[indoline-3,4'-piperidin]-2-one chemical structure, C13H15BrN2O, CAS 1160248-46-3
6-Bromo-1'-methylspiro[indoline-3,4'-piperidin]-2-one
CAS 1160248-46-3C13H15BrN2O
6-Bromospiro[indoline-3,4'-piperidin]-2-one chemical structure, C12H13BrN2O, CAS 1160248-48-5
6-Bromospiro[indoline-3,4'-piperidin]-2-one
CAS 1160248-48-5C12H13BrN2O
tert-Butyl 6-bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate chemical structure, C17H21BrN2O3, CAS 1160247-29-9
tert-Butyl 6-bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
CAS 1160247-29-9C17H21BrN2O3