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Murcko scaffold

Spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one scaffold

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
32
With full pages
12
Scaffold SMILES

O=C1Nc2ccccc2C12OCCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one page
Murcko scaffold O=C1Nc2ccccc2C12OCCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

5-(Hydroxymethyl)-1'-methyl-5-nitrospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C13H14N2O6, CAS 384855-98-5
5-(Hydroxymethyl)-1'-methyl-5-nitrospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 384855-98-5C13H14N2O6
Spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C11H11NO3, CAS 113549-13-6
Spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 113549-13-6C11H11NO3
Methyl 2-(2'-oxospiro[1,3-dioxane-2,3'-indole]-1'-yl)acetate chemical structure, C14H15NO5, CAS 312755-52-5
Methyl 2-(2'-oxospiro[1,3-dioxane-2,3'-indole]-1'-yl)acetate
CAS 312755-52-5C14H15NO5
5'-Bromospiro[[1,3]dioxane-2,3'-indolin]-2'-one chemical structure, C11H10BrNO3, CAS 332073-48-0
5'-Bromospiro[[1,3]dioxane-2,3'-indolin]-2'-one
CAS 332073-48-0C11H10BrNO3
1'-Allyl-5'-methylspiro[[1,3]dioxane-2,3'-indolin]-2'-one chemical structure, C15H17NO3, CAS 304871-60-1
1'-Allyl-5'-methylspiro[[1,3]dioxane-2,3'-indolin]-2'-one
CAS 304871-60-1C15H17NO3
2-(5'-Methyl-2'-oxospiro[1,3-dioxane-2,3'-indole]-1'-yl)acetohydrazide chemical structure, C14H17N3O4, CAS 320741-49-9
2-(5'-Methyl-2'-oxospiro[1,3-dioxane-2,3'-indole]-1'-yl)acetohydrazide
CAS 320741-49-9C14H17N3O4
5'-Methylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C12H13NO3, CAS 853751-57-2
5'-Methylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 853751-57-2C12H13NO3
1'-Allyl-5'-chlorospiro[[1,3]dioxane-2,3'-indolin]-2'-one chemical structure, C14H14ClNO3, CAS 853751-70-9
1'-Allyl-5'-chlorospiro[[1,3]dioxane-2,3'-indolin]-2'-one
CAS 853751-70-9C14H14ClNO3
1'-Allylspiro[[1,3]dioxane-2,3'-indolin]-2'-one chemical structure, C14H15NO3, CAS 853751-62-9
1'-Allylspiro[[1,3]dioxane-2,3'-indolin]-2'-one
CAS 853751-62-9C14H15NO3
5'-Chlorospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C11H10ClNO3, CAS 853902-11-1
5'-Chlorospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 853902-11-1C11H10ClNO3
4',7'-Dimethylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C13H15NO3, CAS 883654-38-4
4',7'-Dimethylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 883654-38-4C13H15NO3
4',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxane-2,3'-indole]-2'-one chemical structure, C16H19NO3, CAS 883655-57-0
4',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxane-2,3'-indole]-2'-one
CAS 883655-57-0C16H19NO3
(4',7'-Dimethyl-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)acetonitrile chemical structure, C15H16N2O3, CAS 883655-64-9
(4',7'-Dimethyl-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)acetonitrile
CAS 883655-64-9C15H16N2O3
5',7'-Dimethylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C13H15NO3, CAS 883633-85-0
5',7'-Dimethylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 883633-85-0C13H15NO3
5',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxane-2,3'-indole]-2'-one chemical structure, C16H19NO3, CAS 883634-31-9
5',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxane-2,3'-indole]-2'-one
CAS 883634-31-9C16H19NO3
5'-Chloro-1'-(3-methylbutyl)spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C16H20ClNO3, CAS 883639-02-9
5'-Chloro-1'-(3-methylbutyl)spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 883639-02-9C16H20ClNO3
7'-Chlorospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C11H10ClNO3, CAS 883639-70-1
7'-Chlorospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 883639-70-1C11H10ClNO3
1'-Allyl-7'-chlorospiro[[1,3]dioxane-2,3'-indolin]-2'-one chemical structure, C14H14ClNO3, CAS 883640-37-7
1'-Allyl-7'-chlorospiro[[1,3]dioxane-2,3'-indolin]-2'-one
CAS 883640-37-7C14H14ClNO3
(7'-Chloro-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)acetonitrile chemical structure, C13H11ClN2O3, CAS 883640-41-3
(7'-Chloro-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)acetonitrile
CAS 883640-41-3C13H11ClN2O3
6',7'-Dichlorospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C11H9Cl2NO3, CAS 883647-79-8
6',7'-Dichlorospiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 883647-79-8C11H9Cl2NO3
(6',7'-Dichloro-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)acetonitrile chemical structure, C13H10Cl2N2O3, CAS 883649-19-2
(6',7'-Dichloro-2'-oxospiro[1,3-dioxane-2,3'-indol]-1'(2'H)-yl)acetonitrile
CAS 883649-19-2C13H10Cl2N2O3
1'-Ethyl-4',7'-dimethylspiro[1,3-dioxane-2,3'-indole]-2'-one chemical structure, C15H19NO3, CAS 883654-52-2
1'-Ethyl-4',7'-dimethylspiro[1,3-dioxane-2,3'-indole]-2'-one
CAS 883654-52-2C15H19NO3
1'-Butyl-4',7'-dimethylspiro[1,3-dioxane-2,3'-indole]-2'-one chemical structure, C17H23NO3, CAS 883654-80-6
1'-Butyl-4',7'-dimethylspiro[1,3-dioxane-2,3'-indole]-2'-one
CAS 883654-80-6C17H23NO3
5'-Bromo-1'-methylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one chemical structure, C12H12BrNO3, CAS 883636-17-7
5'-Bromo-1'-methylspiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one
CAS 883636-17-7C12H12BrNO3