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Murcko scaffold

Ring system with 4 rings and 25 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
12
With full pages
1
Scaffold SMILES

O=C(c1ccccc1)c1ccc2c(c1)C(=O)N(c1ccccc1)C2=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)c1ccc2c(c1)C(=O)N(c1ccccc1)C2=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

5-Benzoyl-2-(4-hydroxyphenyl)isoindole-1,3-dione chemical structure, C21H13NO4, CAS 331269-96-6
5-Benzoyl-2-(4-hydroxyphenyl)isoindole-1,3-dione
CAS 331269-96-6C21H13NO4
5-Benzoyl-2-(4-methoxyphenyl)isoindole-1,3-dione chemical structure, C22H15NO4, CAS 313259-63-1
5-Benzoyl-2-(4-methoxyphenyl)isoindole-1,3-dione
CAS 313259-63-1C22H15NO4
N-[4-[5-(3-Nitrobenzoyl)-1,3-dioxoisoindol-2-yl]phenyl]acetamide chemical structure, C23H15N3O6, CAS 332412-29-0
N-[4-[5-(3-Nitrobenzoyl)-1,3-dioxoisoindol-2-yl]phenyl]acetamide
CAS 332412-29-0C23H15N3O6
2-(2-Hydroxyphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione chemical structure, C21H12N2O6, CAS 404591-21-5
2-(2-Hydroxyphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione
CAS 404591-21-5C21H12N2O6
4-{[2-(4-Methoxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl}benzoic acid chemical structure, C23H15NO6, CAS 325799-61-9
4-{[2-(4-Methoxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl}benzoic acid
CAS 325799-61-9C23H15NO6
Methyl 3-[5-(3-nitrobenzoyl)-1,3-dioxoisoindol-2-yl]benzoate chemical structure, C23H14N2O7, CAS 6090-88-6
Methyl 3-[5-(3-nitrobenzoyl)-1,3-dioxoisoindol-2-yl]benzoate
CAS 6090-88-6C23H14N2O7
2-(3-Ethynylphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione chemical structure, C23H12N2O5, CAS 294667-18-8
2-(3-Ethynylphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione
CAS 294667-18-8C23H12N2O5
2-(2-Methoxyphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione chemical structure, C22H14N2O6, CAS 330635-06-8
2-(2-Methoxyphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione
CAS 330635-06-8C22H14N2O6
2-(4-Methoxyphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione chemical structure, C22H14N2O6, CAS 330635-11-5
2-(4-Methoxyphenyl)-5-(3-nitrobenzoyl)isoindole-1,3-dione
CAS 330635-11-5C22H14N2O6
3-(5-(3-Nitrobenzoyl)-1,3-dioxoisoindolin-2-yl)benzoic acid chemical structure, C22H12N2O7, CAS 295348-05-9
3-(5-(3-Nitrobenzoyl)-1,3-dioxoisoindolin-2-yl)benzoic acid
CAS 295348-05-9C22H12N2O7
3-[1,3-Dioxo-5-(phenylcarbonyl)-1,3-dihydro-2H-isoindol-2-yl]benzoic acid chemical structure, C22H13NO5, CAS 313399-25-6
3-[1,3-Dioxo-5-(phenylcarbonyl)-1,3-dihydro-2H-isoindol-2-yl]benzoic acid
CAS 313399-25-6C22H13NO5
2-{5-[(3-Nitrophenyl)carbonyl]-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl}benzoic acid chemical structure, C22H12N2O7, CAS 294890-28-1
2-{5-[(3-Nitrophenyl)carbonyl]-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl}benzoic acid
CAS 294890-28-1C22H12N2O7