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Murcko scaffold

Ring system with 4 rings and 25 atoms

55 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
55
With full pages
1
Scaffold SMILES

O=S(=O)(c1cccc2ccccc12)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1cccc2ccccc12)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

1-(3-Chlorophenyl)-4-((4-ethoxynaphthalen-1-yl)sulfonyl)piperazine chemical structure, C22H23ClN2O3S, CAS 667892-57-1
1-(3-Chlorophenyl)-4-((4-ethoxynaphthalen-1-yl)sulfonyl)piperazine
CAS 667892-57-1C22H23ClN2O3S
4-(2,4-Dimethylphenyl)-1-[(4-methoxynaphthyl)sulfonyl]piperazine chemical structure, C23H26N2O3S, CAS 667892-98-0
4-(2,4-Dimethylphenyl)-1-[(4-methoxynaphthyl)sulfonyl]piperazine
CAS 667892-98-0C23H26N2O3S
1-[(4-Ethoxynaphthyl)sulfonyl]-4-phenylpiperazine chemical structure, C22H24N2O3S, CAS 332021-04-2
1-[(4-Ethoxynaphthyl)sulfonyl]-4-phenylpiperazine
CAS 332021-04-2C22H24N2O3S
1-[(4-Ethoxynaphthalen-1-yl)sulfonyl]-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C23H23F3N2O3S, CAS 691380-76-4
1-[(4-Ethoxynaphthalen-1-yl)sulfonyl]-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 691380-76-4C23H23F3N2O3S
1-(4-Fluorophenyl)-4-(naphthylsulfonyl)piperazine chemical structure, C20H19FN2O2S, CAS 309291-34-7
1-(4-Fluorophenyl)-4-(naphthylsulfonyl)piperazine
CAS 309291-34-7C20H19FN2O2S
1-(2,3-Dimethylphenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C23H26N2O3S, CAS 681852-68-6
1-(2,3-Dimethylphenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 681852-68-6C23H26N2O3S
4-(3,4-Dichlorophenyl)-1-(naphthylsulfonyl)piperazine chemical structure, C20H18Cl2N2O2S, CAS 681852-81-3
4-(3,4-Dichlorophenyl)-1-(naphthylsulfonyl)piperazine
CAS 681852-81-3C20H18Cl2N2O2S
1-(3,4-Dichlorophenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C21H20Cl2N2O3S, CAS 681852-82-4
1-(3,4-Dichlorophenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 681852-82-4C21H20Cl2N2O3S
1-(3,4-Dichlorophenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C22H22Cl2N2O3S, CAS 681852-84-6
1-(3,4-Dichlorophenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 681852-84-6C22H22Cl2N2O3S
1-[(4-Chloronaphthalen-1-yl)sulfonyl]-4-(2,3-dimethylphenyl)piperazine chemical structure, C22H23ClN2O2S, CAS 681854-21-7
1-[(4-Chloronaphthalen-1-yl)sulfonyl]-4-(2,3-dimethylphenyl)piperazine
CAS 681854-21-7C22H23ClN2O2S
1-(2,6-Dimethylphenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C24H28N2O3S, CAS 682762-38-5
1-(2,6-Dimethylphenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 682762-38-5C24H28N2O3S
1-(2,5-Dichlorophenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C22H22Cl2N2O3S, CAS 633280-13-4
1-(2,5-Dichlorophenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 633280-13-4C22H22Cl2N2O3S
1-[(4-Chloronaphthalen-1-yl)sulfonyl]-4-(4-fluorophenyl)piperazine chemical structure, C20H18ClFN2O2S, CAS 325813-05-6
1-[(4-Chloronaphthalen-1-yl)sulfonyl]-4-(4-fluorophenyl)piperazine
CAS 325813-05-6C20H18ClFN2O2S
1-[(4-Ethoxynaphthyl)sulfonyl]-4-(2-ethylphenyl)piperazine chemical structure, C24H28N2O3S, CAS 695174-64-2
1-[(4-Ethoxynaphthyl)sulfonyl]-4-(2-ethylphenyl)piperazine
CAS 695174-64-2C24H28N2O3S
1-(4-Chlorophenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C22H23ClN2O3S, CAS 700858-94-2
1-(4-Chlorophenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 700858-94-2C22H23ClN2O3S
1-[(4-Methoxynaphthyl)sulfonyl]-4-(2,4,6-trimethylphenyl)piperazine chemical structure, C24H28N2O3S, CAS 700859-03-6
1-[(4-Methoxynaphthyl)sulfonyl]-4-(2,4,6-trimethylphenyl)piperazine
CAS 700859-03-6C24H28N2O3S
1-(2-Chlorophenyl)-4-naphthalen-1-ylsulfonylpiperazine chemical structure, C20H19ClN2O2S, CAS 701941-15-3
1-(2-Chlorophenyl)-4-naphthalen-1-ylsulfonylpiperazine
CAS 701941-15-3C20H19ClN2O2S
1-(2-Chlorophenyl)-4-(4-methoxynaphthalen-1-yl)sulfonylpiperazine chemical structure, C21H21ClN2O3S, CAS 701949-44-2
1-(2-Chlorophenyl)-4-(4-methoxynaphthalen-1-yl)sulfonylpiperazine
CAS 701949-44-2C21H21ClN2O3S
1-(2-Ethylphenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C23H26N2O3S, CAS 696627-41-5
1-(2-Ethylphenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 696627-41-5C23H26N2O3S
1-(2,5-Dichlorophenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C21H20Cl2N2O3S, CAS 713099-87-7
1-(2,5-Dichlorophenyl)-4-[(4-methoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 713099-87-7C21H20Cl2N2O3S
1-(3,4-Dimethylphenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine chemical structure, C24H28N2O3S, CAS 694486-38-9
1-(3,4-Dimethylphenyl)-4-[(4-ethoxynaphthalen-1-yl)sulfonyl]piperazine
CAS 694486-38-9C24H28N2O3S
1-(2-Ethoxyphenyl)-4-(4-methoxynaphthalen-1-yl)sulfonylpiperazine chemical structure, C23H26N2O4S, CAS 433705-11-4
1-(2-Ethoxyphenyl)-4-(4-methoxynaphthalen-1-yl)sulfonylpiperazine
CAS 433705-11-4C23H26N2O4S
1-[(4-Chloro-1-naphthyl)sulfonyl]-4-phenylpiperazine chemical structure, C20H19ClN2O2S, CAS 325812-54-2
1-[(4-Chloro-1-naphthyl)sulfonyl]-4-phenylpiperazine
CAS 325812-54-2C20H19ClN2O2S
1-[(4-Ethoxynaphthyl)sulfonyl]-4-(4-fluorophenyl)piperazine chemical structure, C22H23FN2O3S, CAS 325813-06-7
1-[(4-Ethoxynaphthyl)sulfonyl]-4-(4-fluorophenyl)piperazine
CAS 325813-06-7C22H23FN2O3S