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Murcko scaffold

Ring system with 4 rings and 24 atoms

110 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 110
With full pages: 15

Scaffold SMILES

O=c1cc(CN2CCN(c3ccccc3)CC2)c2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1cc(CN2CCN(c3ccccc3)CC2)c2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 110 chemicals

6-Chloro-4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-5,7-dimethylchromen-2-one chemical structure, C23H25ClN2O3, CAS 850746-00-8

6-Chloro-4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-5,7-dimethylchromen-2-one

CAS 850746-00-8C₂₃H₂₅ClN₂O₃

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-6-(propan-2-yl)-2H-chromen-2-one chemical structure, C23H25FN2O2, CAS 850761-91-0

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-6-(propan-2-yl)-2H-chromen-2-one

CAS 850761-91-0C₂₃H₂₅FN₂O₂

6-Ethyl-4-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C22H23FN2O2, CAS 862245-41-8

6-Ethyl-4-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-2H-chromen-2-one

CAS 862245-41-8C₂₂H₂₃FN₂O₂

4-[(4-Phenylpiperazin-1-yl)methyl]-6-(propan-2-yl)-2H-chromen-2-one chemical structure, C23H26N2O2, CAS 877783-58-9

4-[(4-Phenylpiperazin-1-yl)methyl]-6-(propan-2-yl)-2H-chromen-2-one

CAS 877783-58-9C₂₃H₂₆N₂O₂

6-Chloro-4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C21H21ClN2O3, CAS 896071-08-2

6-Chloro-4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)-2H-chromen-2-one

CAS 896071-08-2C₂₁H₂₁ClN₂O₃

7-Methoxy-4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C22H24N2O4, CAS 854132-81-3

7-Methoxy-4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2H-chromen-2-one

CAS 854132-81-3C₂₂H₂₄N₂O₄

4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-7-methoxy-2H-chromen-2-one chemical structure, C21H21ClN2O3, CAS 859858-18-7

4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-7-methoxy-2H-chromen-2-one

CAS 859858-18-7C₂₁H₂₁ClN₂O₃

4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one chemical structure, C20H19ClN2O3, CAS 859859-96-4

4-((4-(3-Chlorophenyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one

CAS 859859-96-4C₂₀H₁₉ClN₂O₃

6-Hydroxy-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one chemical structure, C20H20N2O3, CAS 859870-09-0

6-Hydroxy-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one

CAS 859870-09-0C₂₀H₂₀N₂O₃

6-Hydroxy-4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one chemical structure, C22H24N2O4, CAS 859107-72-5

6-Hydroxy-4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one

CAS 859107-72-5C₂₂H₂₄N₂O₄

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-6-hydroxy-7-methyl-2H-chromen-2-one chemical structure, C21H21FN2O3, CAS 859112-01-9

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-6-hydroxy-7-methyl-2H-chromen-2-one

CAS 859112-01-9C₂₁H₂₁FN₂O₃

7-Methoxy-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one chemical structure, C21H22N2O3, CAS 859116-96-4

7-Methoxy-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one

CAS 859116-96-4C₂₁H₂₂N₂O₃

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one chemical structure, C20H19FN2O3, CAS 859126-83-3

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-6-hydroxy-2H-chromen-2-one

CAS 859126-83-3C₂₀H₁₉FN₂O₃

4-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-6-hydroxy-7-methyl-2H-chromen-2-one chemical structure, C21H21ClN2O3, CAS 859127-25-6

4-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-6-hydroxy-7-methyl-2H-chromen-2-one

CAS 859127-25-6C₂₁H₂₁ClN₂O₃

6-Hydroxy-4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one chemical structure, C21H22N2O4, CAS 859129-86-5

6-Hydroxy-4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]chromen-2-one

CAS 859129-86-5C₂₁H₂₂N₂O₄

6-Hydroxy-7-methyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one chemical structure, C21H22N2O3, CAS 859130-20-4

6-Hydroxy-7-methyl-4-[(4-phenylpiperazin-1-yl)methyl]chromen-2-one

CAS 859130-20-4C₂₁H₂₂N₂O₃

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-7-methoxy-2H-chromen-2-one chemical structure, C21H21FN2O3, CAS 571921-46-5

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-7-methoxy-2H-chromen-2-one

CAS 571921-46-5C₂₁H₂₁FN₂O₃

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-6-methyl-2H-chromen-2-one chemical structure, C21H21FN2O2, CAS 849913-91-3

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-6-methyl-2H-chromen-2-one

CAS 849913-91-3C₂₁H₂₁FN₂O₂

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one chemical structure, C22H23FN2O2, CAS 849916-20-7

4-{[4-(4-Fluorophenyl)piperazin-1-yl]methyl}-5,7-dimethyl-2H-chromen-2-one

CAS 849916-20-7C₂₂H₂₃FN₂O₂

4-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-6,7-dimethyl-2H-chromen-2-one chemical structure, C22H23ClN2O2, CAS 849537-71-9

4-{[4-(3-Chlorophenyl)piperazin-1-yl]methyl}-6,7-dimethyl-2H-chromen-2-one

CAS 849537-71-9C₂₂H₂₃ClN₂O₂

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-5,7,8-trimethyl-2H-chromen-2-one chemical structure, C23H25FN2O2, CAS 849922-68-5

4-((4-(4-Fluorophenyl)piperazin-1-yl)methyl)-5,7,8-trimethyl-2H-chromen-2-one

CAS 849922-68-5C₂₃H₂₅FN₂O₂

6-Chloro-4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one chemical structure, C21H20ClFN2O2, CAS 850156-51-3

6-Chloro-4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-7-methyl-2H-chromen-2-one

CAS 850156-51-3C₂₁H₂₀ClFN₂O₂

6-Ethyl-4-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C22H23FN2O2, CAS 850190-47-5

6-Ethyl-4-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-2H-chromen-2-one

CAS 850190-47-5C₂₂H₂₃FN₂O₂

6-tert-Butyl-4-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C24H27FN2O2, CAS 850194-39-7

6-tert-Butyl-4-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-2H-chromen-2-one

CAS 850194-39-7C₂₄H₂₇FN₂O₂