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Murcko scaffold

Ring system with 3 rings and 19 atoms

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
23
With full pages
6
Scaffold SMILES

O=C(CC1C(=O)Nc2ccccc21)c1ccccn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)Nc2ccccc21)c1ccccn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

1,3-Dihydro-3-hydroxy-3-(2-oxo-2-(2-pyridinyl)ethyl)-2H-indol-2-one chemical structure, C15H12N2O3, CAS 70452-27-6
1,3-Dihydro-3-hydroxy-3-(2-oxo-2-(2-pyridinyl)ethyl)-2H-indol-2-one
CAS 70452-27-6C15H12N2O3
3-Hydroxy-5-methyl-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C16H14N2O3, CAS 83393-52-6
3-Hydroxy-5-methyl-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 83393-52-6C16H14N2O3
Ethyl {3-hydroxy-2-oxo-3-[2-oxo-2-(pyridin-2-yl)ethyl]-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C19H18N2O5, CAS 356080-92-7
Ethyl {3-hydroxy-2-oxo-3-[2-oxo-2-(pyridin-2-yl)ethyl]-2,3-dihydro-1H-indol-1-yl}acetate
CAS 356080-92-7C19H18N2O5
3-Hydroxy-1-methyl-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one chemical structure, C16H14N2O3, CAS 83393-49-1
3-Hydroxy-1-methyl-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
CAS 83393-49-1C16H14N2O3
1-Ethyl-3-hydroxy-5-nitro-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one chemical structure, C17H15N3O5, CAS 486994-64-3
1-Ethyl-3-hydroxy-5-nitro-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
CAS 486994-64-3C17H15N3O5
1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one chemical structure, C19H20N2O3, CAS 689767-21-3
1-Butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
CAS 689767-21-3C19H20N2O3
3-Hydroxy-5-nitro-3-(2-oxo-2-pyridin-2-ylethyl)-1H-indol-2-one chemical structure, C15H11N3O5, CAS 83393-51-5
3-Hydroxy-5-nitro-3-(2-oxo-2-pyridin-2-ylethyl)-1H-indol-2-one
CAS 83393-51-5C15H11N3O5
5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1H-indol-2-one chemical structure, C15H11ClN2O3, CAS 694450-49-2
5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1H-indol-2-one
CAS 694450-49-2C15H11ClN2O3
3-Hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C18H16N2O3, CAS 439091-26-6
3-Hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one
CAS 439091-26-6C18H16N2O3
4-[3-Hydroxy-2-oxo-3-(2-oxo-2-pyridin-2-ylethyl)indol-1-yl]butanenitrile chemical structure, C19H17N3O3, CAS 439093-56-8
4-[3-Hydroxy-2-oxo-3-(2-oxo-2-pyridin-2-ylethyl)indol-1-yl]butanenitrile
CAS 439093-56-8C19H17N3O3
1-Ethyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one chemical structure, C17H16N2O3, CAS 129055-69-2
1-Ethyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
CAS 129055-69-2C17H16N2O3
2-[3-Hydroxy-2-oxo-3-(2-oxo-2-pyridin-2-ylethyl)indol-1-yl]acetamide chemical structure, C17H15N3O4, CAS 689755-93-9
2-[3-Hydroxy-2-oxo-3-(2-oxo-2-pyridin-2-ylethyl)indol-1-yl]acetamide
CAS 689755-93-9C17H15N3O4
5-Chloro-3-hydroxy-1-methyl-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one chemical structure, C16H13ClN2O3, CAS 838887-00-6
5-Chloro-3-hydroxy-1-methyl-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
CAS 838887-00-6C16H13ClN2O3
4,6-Dichloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1H-indol-2-one chemical structure, C15H10Cl2N2O3, CAS 847854-18-6
4,6-Dichloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1H-indol-2-one
CAS 847854-18-6C15H10Cl2N2O3
5-Bromo-1-butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one chemical structure, C19H19BrN2O3, CAS 688040-20-2
5-Bromo-1-butyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)indol-2-one
CAS 688040-20-2C19H19BrN2O3
5-Bromo-3-hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C15H11BrN2O3, CAS 83393-50-4
5-Bromo-3-hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 83393-50-4C15H11BrN2O3
5-Fluoro-3-hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C15H11FN2O3, CAS 442647-79-2
5-Fluoro-3-hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 442647-79-2C15H11FN2O3
3-Hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-prop-2-ynylindol-2-one chemical structure, C18H14N2O3, CAS 356081-73-7
3-Hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-prop-2-ynylindol-2-one
CAS 356081-73-7C18H14N2O3
5-Bromo-3-hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C18H17BrN2O3, CAS 688038-46-2
5-Bromo-3-hydroxy-3-[2-oxo-2-(pyridin-2-yl)ethyl]-1-propyl-1,3-dihydro-2H-indol-2-one
CAS 688038-46-2C18H17BrN2O3
5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-prop-2-enylindol-2-one chemical structure, C18H15ClN2O3, CAS 879584-45-9
5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-prop-2-enylindol-2-one
CAS 879584-45-9C18H15ClN2O3
5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-propylindol-2-one chemical structure, C18H17ClN2O3, CAS 879579-78-9
5-Chloro-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-propylindol-2-one
CAS 879579-78-9C18H17ClN2O3
7-Chloro-3-hydroxy-3-[2-oxo-2-(2-pyridyl)ethyl]-1,3-dihydro-2H-indol-2-one chemical structure, C15H11ClN2O3, CAS 83393-53-7
7-Chloro-3-hydroxy-3-[2-oxo-2-(2-pyridyl)ethyl]-1,3-dihydro-2H-indol-2-one
CAS 83393-53-7C15H11ClN2O3
6-Ethyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1,3-dihydro-indol-2-one chemical structure, C17H16N2O3, CAS 864685-13-2
6-Ethyl-3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1,3-dihydro-indol-2-one
CAS 864685-13-2C17H16N2O3