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Murcko scaffold

Ring system with 4 rings and 26 atoms

72 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
72
With full pages
21
Scaffold SMILES

O=C(c1cc2ccccc2o1)N(Cc1ccccc1)C1CCS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc2ccccc2o1)N(Cc1ccccc1)C1CCS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C22H23NO5S, CAS 620568-17-4
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide
CAS 620568-17-4C22H23NO5S
N-(3,4-Dimethoxybenzyl)-N-(1,1-dioxidotetrahydro-3-thienyl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C23H25NO6S, CAS 620570-88-9
N-(3,4-Dimethoxybenzyl)-N-(1,1-dioxidotetrahydro-3-thienyl)-3-methyl-1-benzofuran-2-carboxamide
CAS 620570-88-9C23H25NO6S
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,5,6-trimethyl-1-benzofuran-2-carboxamide chemical structure, C23H24ClNO4S, CAS 622350-25-8
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,5,6-trimethyl-1-benzofuran-2-carboxamide
CAS 622350-25-8C23H24ClNO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3,5-dimethyl-1-benzofuran-2-carboxamide chemical structure, C23H25NO5S, CAS 620578-31-6
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3,5-dimethyl-1-benzofuran-2-carboxamide
CAS 620578-31-6C23H25NO5S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3,5-dimethyl-N-[4-(propan-2-yl)benzyl]-1-benzofuran-2-carboxamide chemical structure, C25H29NO4S, CAS 620578-61-2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3,5-dimethyl-N-[4-(propan-2-yl)benzyl]-1-benzofuran-2-carboxamide
CAS 620578-61-2C25H29NO4S
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydro-3-thienyl)-3,5,6-trimethyl-1-benzofuran-2-carboxamide chemical structure, C23H24ClNO4S, CAS 622350-23-6
N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydro-3-thienyl)-3,5,6-trimethyl-1-benzofuran-2-carboxamide
CAS 622350-23-6C23H24ClNO4S
N-(3,4-Dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,5,6-trimethyl-1-benzofuran-2-carboxamide chemical structure, C25H29NO6S, CAS 622350-27-0
N-(3,4-Dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,5,6-trimethyl-1-benzofuran-2-carboxamide
CAS 622350-27-0C25H29NO6S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-3,5-dimethyl-1-benzofuran-2-carboxamide chemical structure, C24H27NO4S, CAS 620578-51-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-3,5-dimethyl-1-benzofuran-2-carboxamide
CAS 620578-51-0C24H27NO4S
5-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C22H22ClNO5S, CAS 714261-89-9
5-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide
CAS 714261-89-9C22H22ClNO5S
5-Bromo-N-(4-chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C21H19BrClNO4S, CAS 714261-97-9
5-Bromo-N-(4-chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide
CAS 714261-97-9C21H19BrClNO4S
N-(3,4-Dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-5-ethyl-3-methyl-1-benzofuran-2-carboxamide chemical structure, C25H29NO6S, CAS 714262-04-1
N-(3,4-Dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-5-ethyl-3-methyl-1-benzofuran-2-carboxamide
CAS 714262-04-1C25H29NO6S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-fluoro-N-(4-methoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C22H22FNO5S, CAS 714262-14-3
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-5-fluoro-N-(4-methoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide
CAS 714262-14-3C22H22FNO5S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C23H25NO5S, CAS 847858-96-2
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-3-methyl-1-benzofuran-2-carboxamide
CAS 847858-96-2C23H25NO5S
2-Benzofurancarboxamide,N-[(4-ethylphenyl)methyl]-3,6-dimethyl-N-(tetrahydro-1,1-dioxido-3-thienyl)-(9CI) chemical structure, C24H27NO4S, CAS 578746-91-5
2-Benzofurancarboxamide,N-[(4-ethylphenyl)methyl]-3,6-dimethyl-N-(tetrahydro-1,1-dioxido-3-thienyl)-(9CI)
CAS 578746-91-5C24H27NO4S
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,6-dimethyl-1-benzofuran-2-carboxamide chemical structure, C22H22ClNO4S, CAS 620569-79-1
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,6-dimethyl-1-benzofuran-2-carboxamide
CAS 620569-79-1C22H22ClNO4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)-3,6-dimethyl-1-benzofuran-2-carboxamide chemical structure, C22H22FNO4S, CAS 843672-30-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-fluorobenzyl)-3,6-dimethyl-1-benzofuran-2-carboxamide
CAS 843672-30-0C22H22FNO4S
2-Benzofurancarboxamide,3,6-dimethyl-N-[[4-(1-methylethyl)phenyl]methyl]-N-(tetrahydro-1,1-dioxido-3-thienyl)-(9CI) chemical structure, C25H29NO4S, CAS 579441-10-4
2-Benzofurancarboxamide,3,6-dimethyl-N-[[4-(1-methylethyl)phenyl]methyl]-N-(tetrahydro-1,1-dioxido-3-thienyl)-(9CI)
CAS 579441-10-4C25H29NO4S
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C21H20ClNO4S, CAS 573944-87-3
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide
CAS 573944-87-3C21H20ClNO4S
N-Benzyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C21H21NO4S, CAS 620567-67-1
N-Benzyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide
CAS 620567-67-1C21H21NO4S
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,6-dimethyl-1-benzofuran-2-carboxamide chemical structure, C24H28N2O4S, CAS 578758-31-3
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3,6-dimethyl-1-benzofuran-2-carboxamide
CAS 578758-31-3C24H28N2O4S
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C23H26N2O4S, CAS 577986-44-8
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide
CAS 577986-44-8C23H26N2O4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-3,6-dimethyl-1-benzofuran-2-carboxamide chemical structure, C24H27NO5S, CAS 843668-67-7
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethoxybenzyl)-3,6-dimethyl-1-benzofuran-2-carboxamide
CAS 843668-67-7C24H27NO5S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-methyl-N-[4-(propan-2-yl)benzyl]-1-benzofuran-2-carboxamide chemical structure, C24H27NO4S, CAS 620571-49-5
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-methyl-N-[4-(propan-2-yl)benzyl]-1-benzofuran-2-carboxamide
CAS 620571-49-5C24H27NO4S
N-(3-Bromobenzyl)-5-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide chemical structure, C21H19BrClNO4S, CAS 877782-45-1
N-(3-Bromobenzyl)-5-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1-benzofuran-2-carboxamide
CAS 877782-45-1C21H19BrClNO4S