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Murcko scaffold

5,6,7,8-Tetrahydropyrido[3,4-D]pyrimidin-4(3H)-one scaffold

36 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 11
Chemicals: 36
With full pages: 5

Scaffold SMILES

O=c1[nH]cnc2c1CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 5,6,7,8-Tetrahydropyrido[3,4-D]pyrimidin-4(3H)-one page

Murcko scaffold O=c1[nH]cnc2c1CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

3-Methyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one chemical structure, C8H11N3O, CAS 1461708-88-2

3-Methyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one

CAS 1461708-88-2C₈H₁₁N₃O

3-Ethyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one chemical structure, C9H13N3O, CAS 1461713-85-8

3-Ethyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one

CAS 1461713-85-8C₉H₁₃N₃O

3-Propyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one chemical structure, C10H15N3O, CAS 1461714-01-1

3-Propyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one

CAS 1461714-01-1C₁₀H₁₅N₃O

3-Methyl-3H,4H,5H,6H,7H,8H-pyrido(3,4-d)pyrimidin-4-one dihydrochloride chemical structure, C8H13Cl2N3O, CAS 1803598-30-2

3-Methyl-3H,4H,5H,6H,7H,8H-pyrido(3,4-d)pyrimidin-4-one dihydrochloride

CAS 1803598-30-2C₈H₁₃Cl₂N₃O

3-Ethyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one dihydrochloride chemical structure, C9H15Cl2N3O, CAS 1788632-16-5

3-Ethyl-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one dihydrochloride

CAS 1788632-16-5C₉H₁₅Cl₂N₃O

3-Ethyl-7-(prop-2-enoyl)-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one chemical structure, C12H15N3O2, CAS 2109146-28-1

3-Ethyl-7-(prop-2-enoyl)-3H,4H,5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-one

CAS 2109146-28-1C₁₂H₁₅N₃O₂

2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-ol chemical structure, C8H8F3N3O, CAS 647862-98-4

2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4-ol

CAS 647862-98-4C₈H₈F₃N₃O

2-Amino-7-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one chemical structure, C8H12N4O, CAS 1428139-88-1

2-Amino-7-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

CAS 1428139-88-1C₈H₁₂N₄O

(7-Methyl-4-oxo-3,4,5,6,7,8-hexahydropyrido[3,4-d]pyrimidin-2-yl)cyanamide chemical structure, C9H11N5O, CAS 1428139-20-1

(7-Methyl-4-oxo-3,4,5,6,7,8-hexahydropyrido[3,4-d]pyrimidin-2-yl)cyanamide

CAS 1428139-20-1C₉H₁₁N₅O

2-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one dihydrochloride chemical structure, C8H13Cl2N3O, CAS 62260-00-8

2-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one dihydrochloride

CAS 62260-00-8C₈H₁₃Cl₂N₃O

2-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one chemical structure, C8H11N3O, CAS 62259-95-4

2-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

CAS 62259-95-4C₈H₁₁N₃O

3H,4H,5H,6H,7H,8H-Pyrido[3,4-d]pyrimidin-4-one hydrochloride chemical structure, C7H10ClN3O, CAS 1171334-07-8

3H,4H,5H,6H,7H,8H-Pyrido[3,4-d]pyrimidin-4-one hydrochloride

CAS 1171334-07-8C₇H₁₀ClN₃O

5,6,7,8-Tetrahydropyrido[3,4-D]pyrimidin-4(3H)-one chemical structure, C7H9N3O, CAS 859826-41-8

5,6,7,8-Tetrahydropyrido[3,4-D]pyrimidin-4(3H)-one

CAS 859826-41-8C₇H₉N₃O

tert-Butyl 4-hydroxy-2-(trifluoromethyl)-5,6-dihydropyrido[3,4-D]pyrimidine-7(8H)-carboxylate chemical structure, C13H16F3N3O3, CAS 1274804-48-6

tert-Butyl 4-hydroxy-2-(trifluoromethyl)-5,6-dihydropyrido[3,4-D]pyrimidine-7(8H)-carboxylate

CAS 1274804-48-6C₁₃H₁₆F₃N₃O₃

(R)-tert-Butyl 4-hydroxy-6-methyl-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate chemical structure, C13H19N3O3, CAS 1826008-03-0

(R)-tert-Butyl 4-hydroxy-6-methyl-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

CAS 1826008-03-0C₁₃H₁₉N₃O₃

tert-Butyl 4-hydroxy-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate chemical structure, C12H17N3O3, CAS 1142188-60-0

tert-Butyl 4-hydroxy-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine-7-carboxylate

CAS 1142188-60-0C₁₂H₁₇N₃O₃

tert-Butyl 4-hydroxy-2-methyl-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate chemical structure, C13H19N3O3, CAS 338739-89-2

tert-Butyl 4-hydroxy-2-methyl-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

CAS 338739-89-2C₁₃H₁₉N₃O₃

7-(tert-Butyl) 6-ethyl 4-oxo-4,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-6,7(1H)-dicarboxylate chemical structure, C15H21N3O5, CAS 1229456-53-4

7-(tert-Butyl) 6-ethyl 4-oxo-4,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-6,7(1H)-dicarboxylate

CAS 1229456-53-4C₁₅H₂₁N₃O₅

8-Methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester chemical structure, C13H19N3O3, CAS 1229455-23-5

8-Methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

CAS 1229455-23-5C₁₃H₁₉N₃O₃

tert-Butyl 6-methyl-4-oxo-4,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-7(1H)-carboxylate chemical structure, C13H19N3O3, CAS 1229455-33-7

tert-Butyl 6-methyl-4-oxo-4,5,6,8-tetrahydropyrido[3,4-d]pyrimidine-7(1H)-carboxylate

CAS 1229455-33-7C₁₃H₁₉N₃O₃

2-Amino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one chemical structure, C7H10N4O, CAS 1241674-80-5

2-Amino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

CAS 1241674-80-5C₇H₁₀N₄O

Ethyl 2-amino-4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate chemical structure, C10H14N4O3, CAS 1241674-70-3

Ethyl 2-amino-4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

CAS 1241674-70-3C₁₀H₁₄N₄O₃

2-Amino-7-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one chemical structure, C9H11F3N4O, CAS 1782248-28-5

2-Amino-7-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

CAS 1782248-28-5C₉H₁₁F₃N₄O

2-(Methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one chemical structure, C8H11N3OS, CAS 1525733-95-2

2-(Methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

CAS 1525733-95-2C₈H₁₁N₃OS