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Murcko scaffold

Ring system with 2 rings and 16 atoms

40 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
40
With full pages
28
Scaffold SMILES

O=c1[nH]cccc1S(=O)(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]cccc1S(=O)(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

4,6-Dimethyl-3-{[3-(trifluoromethyl)phenyl]sulfonyl}-2(1H)-pyridinone chemical structure, C14H12F3NO3S, CAS 861212-06-8
4,6-Dimethyl-3-{[3-(trifluoromethyl)phenyl]sulfonyl}-2(1H)-pyridinone
CAS 861212-06-8C14H12F3NO3S
3-[(5-Fluoro-2-methylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C14H14FNO3S, CAS 866017-31-4
3-[(5-Fluoro-2-methylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 866017-31-4C14H14FNO3S
3-[(4-Fluoro-2-methylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C14H14FNO3S, CAS 866017-32-5
3-[(4-Fluoro-2-methylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 866017-32-5C14H14FNO3S
3-[(3-Bromo-2-methylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C14H14BrNO3S, CAS 866038-60-0
3-[(3-Bromo-2-methylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 866038-60-0C14H14BrNO3S
3-[(2-Fluorophenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C13H12FNO3S, CAS 344278-71-3
3-[(2-Fluorophenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 344278-71-3C13H12FNO3S
1,4,6-Trimethyl-3-(phenylsulfonyl)-2(1H)-pyridinone chemical structure, C14H15NO3S, CAS 344278-75-7
1,4,6-Trimethyl-3-(phenylsulfonyl)-2(1H)-pyridinone
CAS 344278-75-7C14H15NO3S
3-[(2-Methoxyphenyl)sulfonyl]-4,6-dimethyl-1-(2-methyl-2-propenyl)-2(1H)-pyridinone chemical structure, C18H21NO4S, CAS 866051-45-8
3-[(2-Methoxyphenyl)sulfonyl]-4,6-dimethyl-1-(2-methyl-2-propenyl)-2(1H)-pyridinone
CAS 866051-45-8C18H21NO4S
4,6-Dimethyl-3-[(4-methylphenyl)sulfonyl]-1-(2-methyl-2-propenyl)-2(1H)-pyridinone chemical structure, C18H21NO3S, CAS 866051-46-9
4,6-Dimethyl-3-[(4-methylphenyl)sulfonyl]-1-(2-methyl-2-propenyl)-2(1H)-pyridinone
CAS 866051-46-9C18H21NO3S
3-[(2-Chlorophenyl)sulfonyl]-4,6-dimethyl-1-(2-methyl-2-propenyl)-2(1H)-pyridinone chemical structure, C17H18ClNO3S, CAS 866051-47-0
3-[(2-Chlorophenyl)sulfonyl]-4,6-dimethyl-1-(2-methyl-2-propenyl)-2(1H)-pyridinone
CAS 866051-47-0C17H18ClNO3S
3-[(3-Chlorophenyl)sulfonyl]-4,6-dimethyl-1-(2-methyl-2-propenyl)-2(1H)-pyridinone chemical structure, C17H18ClNO3S, CAS 866051-48-1
3-[(3-Chlorophenyl)sulfonyl]-4,6-dimethyl-1-(2-methyl-2-propenyl)-2(1H)-pyridinone
CAS 866051-48-1C17H18ClNO3S
4,6-Dimethyl-3-[(3-methylphenyl)sulfonyl]-1-(2-methyl-2-propenyl)-2(1H)-pyridinone chemical structure, C18H21NO3S, CAS 866051-49-2
4,6-Dimethyl-3-[(3-methylphenyl)sulfonyl]-1-(2-methyl-2-propenyl)-2(1H)-pyridinone
CAS 866051-49-2C18H21NO3S
3-[(2-Chlorophenyl)sulfonyl]-1-ethyl-4,6-dimethyl-2(1H)-pyridinone chemical structure, C15H16ClNO3S, CAS 866051-50-5
3-[(2-Chlorophenyl)sulfonyl]-1-ethyl-4,6-dimethyl-2(1H)-pyridinone
CAS 866051-50-5C15H16ClNO3S
1,4,6-Trimethyl-3-[(2-methylphenyl)sulfonyl]-2(1H)-pyridinone chemical structure, C15H17NO3S, CAS 344279-00-1
1,4,6-Trimethyl-3-[(2-methylphenyl)sulfonyl]-2(1H)-pyridinone
CAS 344279-00-1C15H17NO3S
1-Isobutyl-4,6-dimethyl-3-[(2-methylphenyl)sulfonyl]-2(1H)-pyridinone chemical structure, C18H23NO3S, CAS 866051-53-8
1-Isobutyl-4,6-dimethyl-3-[(2-methylphenyl)sulfonyl]-2(1H)-pyridinone
CAS 866051-53-8C18H23NO3S
4,6-Dimethyl-3-(2-methylphenyl)sulfonyl-1-propan-2-ylpyridin-2-one chemical structure, C17H21NO3S, CAS 866051-54-9
4,6-Dimethyl-3-(2-methylphenyl)sulfonyl-1-propan-2-ylpyridin-2-one
CAS 866051-54-9C17H21NO3S
3-[(3-Chloro-2,6-dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C15H16ClNO3S, CAS 860787-62-8
3-[(3-Chloro-2,6-dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 860787-62-8C15H16ClNO3S
3-[(2,4-Dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C15H17NO3S, CAS 860787-65-1
3-[(2,4-Dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 860787-65-1C15H17NO3S
3-[(2,5-Dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C15H17NO3S, CAS 860787-70-8
3-[(2,5-Dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 860787-70-8C15H17NO3S
3-[(2,3-Dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C15H17NO3S, CAS 866143-35-3
3-[(2,3-Dimethylphenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 866143-35-3C15H17NO3S
4,6-Dimethyl-3-(phenylsulfonyl)-2(1H)-pyridinone chemical structure, C13H13NO3S, CAS 113123-43-6
4,6-Dimethyl-3-(phenylsulfonyl)-2(1H)-pyridinone
CAS 113123-43-6C13H13NO3S
5-Chloro-4,6-dimethyl-3-(phenylsulfonyl)-2(1H)-pyridinone chemical structure, C13H12ClNO3S, CAS 338398-23-5
5-Chloro-4,6-dimethyl-3-(phenylsulfonyl)-2(1H)-pyridinone
CAS 338398-23-5C13H12ClNO3S
4,6-Dimethyl-3-[(2-methylphenyl)sulfonyl]-1-(2-propynyl)-2(1H)-pyridinone chemical structure, C17H17NO3S, CAS 477864-59-8
4,6-Dimethyl-3-[(2-methylphenyl)sulfonyl]-1-(2-propynyl)-2(1H)-pyridinone
CAS 477864-59-8C17H17NO3S
3-[(3-Chlorophenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone chemical structure, C13H12ClNO3S, CAS 338964-30-0
3-[(3-Chlorophenyl)sulfonyl]-4,6-dimethyl-2(1H)-pyridinone
CAS 338964-30-0C13H12ClNO3S
4,5,6-Trimethyl-3-[(4-methylphenyl)sulfonyl]-2(1H)-pyridinone chemical structure, C15H17NO3S, CAS 321431-56-5
4,5,6-Trimethyl-3-[(4-methylphenyl)sulfonyl]-2(1H)-pyridinone
CAS 321431-56-5C15H17NO3S