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Murcko scaffold

3-(Pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one scaffold

15 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 12
Chemicals: 15
With full pages: 3

Scaffold SMILES

O=c1[nH]nc(-c2ccccn2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 3-(Pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one page

Murcko scaffold O=c1[nH]nc(-c2ccccn2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

N-(2-(4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)propane-1-sulfonamide chemical structure, C13H19N5O3S, CAS 1211615-76-7

N-(2-(4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)propane-1-sulfonamide

CAS 1211615-76-7C₁₃H₁₉N₅O₃S

1-{2-[(Dimethylsulfamoyl)amino]ethyl}-4-methyl-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C12H18N6O3S, CAS 1208838-75-8

1-{2-[(Dimethylsulfamoyl)amino]ethyl}-4-methyl-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

CAS 1208838-75-8C₁₂H₁₈N₆O₃S

1-Ethyl-3-(2-(4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)urea chemical structure, C13H18N6O2, CAS 1211375-20-0

1-Ethyl-3-(2-(4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)urea

CAS 1211375-20-0C₁₃H₁₈N₆O₂

N-{2-[4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]ethyl}acetamide chemical structure, C12H15N5O2, CAS 1211685-36-7

N-{2-[4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]ethyl}acetamide

CAS 1211685-36-7C₁₂H₁₅N₅O₂

N-(2-(4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)butyramide chemical structure, C14H19N5O2, CAS 1208973-59-4

N-(2-(4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)butyramide

CAS 1208973-59-4C₁₄H₁₉N₅O₂

2-Methyl-N-{2-[4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]ethyl}propanamide chemical structure, C14H19N5O2, CAS 1208734-15-9

2-Methyl-N-{2-[4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]ethyl}propanamide

CAS 1208734-15-9C₁₄H₁₉N₅O₂

N-(2-(4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)propionamide chemical structure, C13H17N5O2, CAS 1209363-99-4

N-(2-(4-Methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)ethyl)propionamide

CAS 1209363-99-4C₁₃H₁₇N₅O₂

2-Methoxy-N-{2-[4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]ethyl}acetamide chemical structure, C13H17N5O3, CAS 1210516-76-9

2-Methoxy-N-{2-[4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]ethyl}acetamide

CAS 1210516-76-9C₁₃H₁₇N₅O₃

tert-Butyl 2-(4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetate chemical structure, C14H18N4O3, CAS 1798524-44-3

tert-Butyl 2-(4-methyl-5-oxo-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetate

CAS 1798524-44-3C₁₄H₁₈N₄O₃

4-Methyl-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C8H8N4O, CAS 1928719-87-2

4-Methyl-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

CAS 1928719-87-2C₈H₈N₄O

1,4-Dimethyl-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C9H10N4O, CAS 2200177-85-9

1,4-Dimethyl-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

CAS 2200177-85-9C₉H₁₀N₄O

4-(2-Methylpropyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C11H14N4O, CAS 2199509-49-2

4-(2-Methylpropyl)-3-(pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

CAS 2199509-49-2C₁₁H₁₄N₄O

3-(Pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C7H6N4O, CAS 56041-30-6

3-(Pyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

CAS 56041-30-6C₇H₆N₄O

3-(5-Bromopyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C7H5BrN4O, CAS 1566681-34-2

3-(5-Bromopyridin-2-yl)-4,5-dihydro-1H-1,2,4-triazol-5-one

CAS 1566681-34-2C₇H₅BrN₄O

3-(5-Chloropyridin-2-yl)-4-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one chemical structure, C8H7ClN4O, CAS 2361883-30-7

3-(5-Chloropyridin-2-yl)-4-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one

CAS 2361883-30-7C₈H₇ClN₄O