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Murcko scaffold

Ring system with 3 rings and 19 atoms

44 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
44
With full pages
8
Scaffold SMILES

O=C1CC(c2ccccc2)C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 44 of 44 chemicals

3-Chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)benzenesulfonamide chemical structure, C16H13ClN2O4S, CAS 30279-49-3
3-Chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)benzenesulfonamide
CAS 30279-49-3C16H13ClN2O4S
3-Methyl-1,3-diphenylpyrrolidine-2,5-dione chemical structure, C17H15NO2, CAS 5685-21-2
3-Methyl-1,3-diphenylpyrrolidine-2,5-dione
CAS 5685-21-2C17H15NO2
4-(3-Ethyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide chemical structure, C18H18N2O4S, CAS 28093-47-2
4-(3-Ethyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide
CAS 28093-47-2C18H18N2O4S
Benzenesulfonamide, 4-(2,5-dioxo-3-(4-chlorophenyl)-3-methyl-1-pyrrolidinyl)- chemical structure, C17H15ClN2O4S, CAS 28103-45-9
Benzenesulfonamide, 4-(2,5-dioxo-3-(4-chlorophenyl)-3-methyl-1-pyrrolidinyl)-
CAS 28103-45-9C17H15ClN2O4S
Benzenesulfonamide, 4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)- chemical structure, C16H14N2O4S, CAS 28103-46-0
Benzenesulfonamide, 4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)-
CAS 28103-46-0C16H14N2O4S
Benzenesulfonamide, 4-(4-butyl-2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)- chemical structure, C21H24N2O4S, CAS 28103-49-3
Benzenesulfonamide, 4-(4-butyl-2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)-
CAS 28103-49-3C21H24N2O4S
4-(3-Butyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide chemical structure, C20H22N2O4S, CAS 28103-52-8
4-(3-Butyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide
CAS 28103-52-8C20H22N2O4S
Benzenesulfonamide, 4-(3,4-dimethyl-2,5-dioxo-3-phenyl-1-pyrrolidinyl)- chemical structure, C18H18N2O4S, CAS 28103-55-1
Benzenesulfonamide, 4-(3,4-dimethyl-2,5-dioxo-3-phenyl-1-pyrrolidinyl)-
CAS 28103-55-1C18H18N2O4S
3-(3-Methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide chemical structure, C17H16N2O4S, CAS 28103-56-2
3-(3-Methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide
CAS 28103-56-2C17H16N2O4S
2-Chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)benzenesulfonamide chemical structure, C16H13ClN2O4S, CAS 30279-17-5
2-Chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)benzenesulfonamide
CAS 30279-17-5C16H13ClN2O4S
Benzenesulfonamide, 2-chloro-4-(2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)- chemical structure, C17H15ClN2O4S, CAS 30279-21-1
Benzenesulfonamide, 2-chloro-4-(2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)-
CAS 30279-21-1C17H15ClN2O4S
4-Chloro-3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide chemical structure, C17H15ClN2O4S, CAS 30279-22-2
4-Chloro-3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide
CAS 30279-22-2C17H15ClN2O4S
Benzenesulfonamide, 3-bromo-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)- chemical structure, C16H13BrN2O4S, CAS 30279-46-0
Benzenesulfonamide, 3-bromo-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)-
CAS 30279-46-0C16H13BrN2O4S
3-Fluoro-4-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide chemical structure, C17H15FN2O4S, CAS 30280-06-9
3-Fluoro-4-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide
CAS 30280-06-9C17H15FN2O4S
3-Chloro-4-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide chemical structure, C17H15ClN2O4S, CAS 30438-05-2
3-Chloro-4-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide
CAS 30438-05-2C17H15ClN2O4S
Benzenesulfonamide, 4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)-3-fluoro- chemical structure, C16H13FN2O4S, CAS 30438-06-3
Benzenesulfonamide, 4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)-3-fluoro-
CAS 30438-06-3C16H13FN2O4S
Benzenesulfonamide, 4-(2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)-2-fluoro- chemical structure, C17H15FN2O4S, CAS 31150-98-8
Benzenesulfonamide, 4-(2,5-dioxo-3-methyl-3-phenyl-1-pyrrolidinyl)-2-fluoro-
CAS 31150-98-8C17H15FN2O4S
1-(4-Chlorophenyl)-3-phenylpyrrolidine-2,5-dione chemical structure, C16H12ClNO2, CAS 31591-72-7
1-(4-Chlorophenyl)-3-phenylpyrrolidine-2,5-dione
CAS 31591-72-7C16H12ClNO2
4-(3-Methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide chemical structure, C17H16N2O4S, CAS 28093-46-1
4-(3-Methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)benzene-1-sulfonamide
CAS 28093-46-1C17H16N2O4S
N-[4-[2,5-Dioxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]phenyl]-2,2,2-trifluoroacetamide chemical structure, C19H12F6N2O4, CAS 499782-94-4
N-[4-[2,5-Dioxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]phenyl]-2,2,2-trifluoroacetamide
CAS 499782-94-4C19H12F6N2O4
1-(4-Methoxyphenyl)-3-[4-(propan-2-yloxy)phenyl]pyrrolidine-2,5-dione chemical structure, C20H21NO4, CAS 312585-50-5
1-(4-Methoxyphenyl)-3-[4-(propan-2-yloxy)phenyl]pyrrolidine-2,5-dione
CAS 312585-50-5C20H21NO4
2-{2,5-Dioxo-3-[4-(propan-2-yloxy)phenyl]pyrrolidin-1-yl}benzoic acid chemical structure, C20H19NO5, CAS 332374-80-8
2-{2,5-Dioxo-3-[4-(propan-2-yloxy)phenyl]pyrrolidin-1-yl}benzoic acid
CAS 332374-80-8C20H19NO5
4-[2,5-Dioxo-3-(4-propan-2-yloxyphenyl)pyrrolidin-1-yl]benzoic acid chemical structure, C20H19NO5, CAS 381692-63-3
4-[2,5-Dioxo-3-(4-propan-2-yloxyphenyl)pyrrolidin-1-yl]benzoic acid
CAS 381692-63-3C20H19NO5
Benzenesulfonamide, 4-(3-(3,5-dibromophenyl)-2,5-dioxo-1-pyrrolidinyl)- chemical structure, C16H12Br2N2O4S, CAS 93553-57-2
Benzenesulfonamide, 4-(3-(3,5-dibromophenyl)-2,5-dioxo-1-pyrrolidinyl)-
CAS 93553-57-2C16H12Br2N2O4S