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Murcko scaffold

Ring system with 4 rings and 23 atoms

131 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
131
With full pages
2
Scaffold SMILES

O=C(Nc1ccccc1)c1cn2cc(-c3ccccc3)nc2s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cn2cc(-c3ccccc3)nc2s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 131 chemicals

N-(5-Acetamido-2-methoxyphenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C23H22N4O4S, CAS 852135-19-4
N-(5-Acetamido-2-methoxyphenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852135-19-4C23H22N4O4S
N-(3-Acetamidophenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C22H20N4O3S, CAS 852135-15-0
N-(3-Acetamidophenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852135-15-0C22H20N4O3S
6-(4-Methoxyphenyl)-3-methyl-N-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C20H17N3O2S, CAS 852134-87-3
6-(4-Methoxyphenyl)-3-methyl-N-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852134-87-3C20H17N3O2S
3-Methyl-N-(4-methylphenyl)-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C20H17N3OS, CAS 868213-71-2
3-Methyl-N-(4-methylphenyl)-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 868213-71-2C20H17N3OS
N-(4-Methoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C20H17N3O2S, CAS 852133-50-7
N-(4-Methoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852133-50-7C20H17N3O2S
N-(3,4-Difluorophenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C20H15F2N3O2S, CAS 852135-04-7
N-(3,4-Difluorophenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852135-04-7C20H15F2N3O2S
Methyl 2-(3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamido)benzoate chemical structure, C21H17N3O3S, CAS 852133-56-3
Methyl 2-(3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamido)benzoate
CAS 852133-56-3C21H17N3O3S
N-(2-Methoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C20H17N3O2S, CAS 852133-48-3
N-(2-Methoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 852133-48-3C20H17N3O2S
N-(2,4-Dimethoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C21H19N3O3S, CAS 852133-61-0
N-(2,4-Dimethoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852133-61-0C21H19N3O3S
N-(2-Fluorophenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C19H14FN3OS, CAS 852133-44-9
N-(2-Fluorophenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 852133-44-9C19H14FN3OS
3-Methyl-6-phenyl-N-(4-sulfamoylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C19H16N4O3S2, CAS 852133-57-4
3-Methyl-6-phenyl-N-(4-sulfamoylphenyl)imidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852133-57-4C19H16N4O3S2
N-(2,5-Dimethoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C21H19N3O3S, CAS 852133-62-1
N-(2,5-Dimethoxyphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 852133-62-1C21H19N3O3S
N-(3,5-Dimethylphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C21H19N3OS, CAS 879918-49-7
N-(3,5-Dimethylphenyl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 879918-49-7C21H19N3OS
N-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C20H13F4N3OS, CAS 933211-79-1
N-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 933211-79-1C20H13F4N3OS
N-(4-Ethylphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C21H19N3OS, CAS 933216-33-2
N-(4-Ethylphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 933216-33-2C21H19N3OS
N-(2,3-Dimethylphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C21H19N3OS, CAS 932995-71-6
N-(2,3-Dimethylphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 932995-71-6C21H19N3OS
Ethyl 2-(6-(4-fluorophenyl)-3-methylimidazo[2,1-b]thiazole-2-carboxamido)benzoate chemical structure, C22H18FN3O3S, CAS 933212-10-3
Ethyl 2-(6-(4-fluorophenyl)-3-methylimidazo[2,1-b]thiazole-2-carboxamido)benzoate
CAS 933212-10-3C22H18FN3O3S
N-(2,4-Dimethylphenyl)-6-(4-fluorophenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C21H18FN3OS, CAS 932995-99-8
N-(2,4-Dimethylphenyl)-6-(4-fluorophenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 932995-99-8C21H18FN3OS
6-(4-Fluorophenyl)-N-(2-methoxy-5-methylphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C21H18FN3O2S, CAS 932996-03-7
6-(4-Fluorophenyl)-N-(2-methoxy-5-methylphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 932996-03-7C21H18FN3O2S
N-(4-Ethoxyphenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide chemical structure, C22H21N3O3S, CAS 932996-23-1
N-(4-Ethoxyphenyl)-6-(4-methoxyphenyl)-3-methylimidazo[2,1-b][1,3]thiazole-2-carboxamide
CAS 932996-23-1C22H21N3O3S
N-(5-Chloro-2-methylphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C20H16ClN3OS, CAS 933216-27-4
N-(5-Chloro-2-methylphenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 933216-27-4C20H16ClN3OS
N-Ethyl-3-methyl-N,6-diphenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C21H19N3OS, CAS 879918-17-9
N-Ethyl-3-methyl-N,6-diphenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 879918-17-9C21H19N3OS
N,3-dimethyl-N,6-diphenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C20H17N3OS, CAS 879918-34-0
N,3-dimethyl-N,6-diphenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 879918-34-0C20H17N3OS
N-(4-Bromophenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide chemical structure, C19H14BrN3OS, CAS 879918-43-1
N-(4-Bromophenyl)-3-methyl-6-phenylimidazo[2,1-b]thiazole-2-carboxamide
CAS 879918-43-1C19H14BrN3OS