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Murcko scaffold

2-(4-(Phenylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole scaffold

53 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
53
With full pages
4
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCN(c2nc3ccccc3[nH]2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(4-(Phenylsulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCN(c2nc3ccccc3[nH]2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 53 chemicals

2-[4-(Benzenesulfonyl)piperazin-1-yl]-1-methylbenzimidazole chemical structure, C18H20N4O2S, CAS 604741-57-3
2-[4-(Benzenesulfonyl)piperazin-1-yl]-1-methylbenzimidazole
CAS 604741-57-3C18H20N4O2S
2-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-1-methylbenzimidazole chemical structure, C18H19FN4O2S, CAS 604741-58-4
2-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-1-methylbenzimidazole
CAS 604741-58-4C18H19FN4O2S
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-1-methylbenzimidazole chemical structure, C18H19ClN4O2S, CAS 604741-59-5
2-[4-(4-Chlorophenyl)sulfonylpiperazin-1-yl]-1-methylbenzimidazole
CAS 604741-59-5C18H19ClN4O2S
2-[4-(4-Methoxyphenyl)sulfonylpiperazin-1-yl]-1-methylbenzimidazole chemical structure, C19H22N4O3S, CAS 604741-60-8
2-[4-(4-Methoxyphenyl)sulfonylpiperazin-1-yl]-1-methylbenzimidazole
CAS 604741-60-8C19H22N4O3S
N-(4-((4-(1-Methyl-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)sulfonyl)phenyl)acetamide chemical structure, C20H23N5O3S, CAS 836669-88-6
N-(4-((4-(1-Methyl-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)sulfonyl)phenyl)acetamide
CAS 836669-88-6C20H23N5O3S
1-Methyl-2-[4-[4-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]benzimidazole chemical structure, C19H19F3N4O2S, CAS 604741-61-9
1-Methyl-2-[4-[4-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]benzimidazole
CAS 604741-61-9C19H19F3N4O2S
1-[3-[4-(1-Methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylphenyl]ethanone chemical structure, C20H22N4O3S, CAS 836669-89-7
1-[3-[4-(1-Methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylphenyl]ethanone
CAS 836669-89-7C20H22N4O3S
1-[4-[4-(1-Methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylphenyl]ethanone chemical structure, C20H22N4O3S, CAS 604741-62-0
1-[4-[4-(1-Methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylphenyl]ethanone
CAS 604741-62-0C20H22N4O3S
1-Ethyl-2-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]benzimidazole chemical structure, C20H24N4O2S, CAS 604741-71-1
1-Ethyl-2-[4-(4-methylphenyl)sulfonylpiperazin-1-yl]benzimidazole
CAS 604741-71-1C20H24N4O2S
Piperazine, 1-(1-ethyl-1H-benzimidazol-2-yl)-4-[(4-fluorophenyl)sulfonyl]- chemical structure, C19H21FN4O2S, CAS 604741-72-2
Piperazine, 1-(1-ethyl-1H-benzimidazol-2-yl)-4-[(4-fluorophenyl)sulfonyl]-
CAS 604741-72-2C19H21FN4O2S
1-Ethyl-2-[4-(4-methoxyphenyl)sulfonyl-1-piperazinyl]benzimidazole chemical structure, C20H24N4O3S, CAS 604741-74-4
1-Ethyl-2-[4-(4-methoxyphenyl)sulfonyl-1-piperazinyl]benzimidazole
CAS 604741-74-4C20H24N4O3S
1-Ethyl-2-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]benzimidazole chemical structure, C19H21FN4O2S, CAS 604741-90-4
1-Ethyl-2-[4-(2-fluorophenyl)sulfonylpiperazin-1-yl]benzimidazole
CAS 604741-90-4C19H21FN4O2S
1-Ethyl-2-[4-(3-fluorophenyl)sulfonylpiperazin-1-yl]benzimidazole chemical structure, C19H21FN4O2S, CAS 604741-91-5
1-Ethyl-2-[4-(3-fluorophenyl)sulfonylpiperazin-1-yl]benzimidazole
CAS 604741-91-5C19H21FN4O2S
1-Methyl-2-(4-tosylpiperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C19H22N4O2S, CAS 432499-78-0
1-Methyl-2-(4-tosylpiperazin-1-yl)-1H-benzo[d]imidazole
CAS 432499-78-0C19H22N4O2S
2-(4-((3-Chloro-4-fluorophenyl)sulfonyl)piperazin-1-yl)-1-methyl-1H-benzo[d]imidazole chemical structure, C18H18ClFN4O2S, CAS 933003-24-8
2-(4-((3-Chloro-4-fluorophenyl)sulfonyl)piperazin-1-yl)-1-methyl-1H-benzo[d]imidazole
CAS 933003-24-8C18H18ClFN4O2S
2-(4-((3-Chlorophenyl)sulfonyl)piperazin-1-yl)-1-methyl-1H-benzo[d]imidazole chemical structure, C18H19ClN4O2S, CAS 1100332-67-9
2-(4-((3-Chlorophenyl)sulfonyl)piperazin-1-yl)-1-methyl-1H-benzo[d]imidazole
CAS 1100332-67-9C18H19ClN4O2S
2-(4-((5-Fluoro-2-methoxyphenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C18H19FN4O3S, CAS 1207011-80-0
2-(4-((5-Fluoro-2-methoxyphenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 1207011-80-0C18H19FN4O3S
2-(4-((4-Methoxyphenyl)sulfonyl)piperazin-1-yl)-5-methyl-1H-benzo[d]imidazole chemical structure, C19H22N4O3S, CAS 1207012-12-1
2-(4-((4-Methoxyphenyl)sulfonyl)piperazin-1-yl)-5-methyl-1H-benzo[d]imidazole
CAS 1207012-12-1C19H22N4O3S
N-(4-((4-(5-Methyl-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)sulfonyl)phenyl)acetamide chemical structure, C20H23N5O3S, CAS 1207028-61-2
N-(4-((4-(5-Methyl-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)sulfonyl)phenyl)acetamide
CAS 1207028-61-2C20H23N5O3S
2-(4-((2-Fluorophenyl)sulfonyl)piperazin-1-yl)-5-methyl-1H-benzo[d]imidazole chemical structure, C18H19FN4O2S, CAS 1207042-57-6
2-(4-((2-Fluorophenyl)sulfonyl)piperazin-1-yl)-5-methyl-1H-benzo[d]imidazole
CAS 1207042-57-6C18H19FN4O2S
1-(4-((4-(5-Methyl-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)sulfonyl)phenyl)ethanone chemical structure, C20H22N4O3S, CAS 1207012-20-1
1-(4-((4-(5-Methyl-1H-benzo[d]imidazol-2-yl)piperazin-1-yl)sulfonyl)phenyl)ethanone
CAS 1207012-20-1C20H22N4O3S
2-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C17H17ClN4O2S, CAS 1211252-19-5
2-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 1211252-19-5C17H17ClN4O2S
2-(4-((2,4-Dimethylphenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C19H22N4O2S, CAS 1209348-45-7
2-(4-((2,4-Dimethylphenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 1209348-45-7C19H22N4O2S
2-(4-((2,5-Dimethylphenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole chemical structure, C19H22N4O2S, CAS 1211292-69-1
2-(4-((2,5-Dimethylphenyl)sulfonyl)piperazin-1-yl)-1H-benzo[d]imidazole
CAS 1211292-69-1C19H22N4O2S