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Murcko scaffold

RefChem:381590 scaffold

23 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
23
With full pages
3
Scaffold SMILES

O=C1c2ccccc2C(=O)N1c1ccc(Oc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the RefChem:381590 page
Murcko scaffold O=C1c2ccccc2C(=O)N1c1ccc(Oc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

1,3-Dioxo-2-[4-(3,4-xylyloxy)phenyl]-5-isoindolinecarboxylic acid chemical structure, C23H17NO5, CAS 201480-87-7
1,3-Dioxo-2-[4-(3,4-xylyloxy)phenyl]-5-isoindolinecarboxylic acid
CAS 201480-87-7C23H17NO5
RefChem:381590 chemical structure, C20H13NO3, CAS 19357-24-5
RefChem:381590
CAS 19357-24-5C20H13NO3
2-[4-(2-Chlorophenoxy)phenyl]-1H-isoindole-1,3(2H)-dione chemical structure, C20H12ClNO3, CAS 521295-65-8
2-[4-(2-Chlorophenoxy)phenyl]-1H-isoindole-1,3(2H)-dione
CAS 521295-65-8C20H12ClNO3
2-(3-Chloro-4-phenoxyphenyl)-1H-isoindole-1,3(2H)-dione chemical structure, C20H12ClNO3, CAS 356090-23-8
2-(3-Chloro-4-phenoxyphenyl)-1H-isoindole-1,3(2H)-dione
CAS 356090-23-8C20H12ClNO3
1,3-Dioxo-2-(4-phenoxyphenyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid chemical structure, C21H13NO5, CAS 306763-60-0
1,3-Dioxo-2-(4-phenoxyphenyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid
CAS 306763-60-0C21H13NO5
5-Bromo-2-[4-(2,3-dimethylphenoxy)phenyl]-1H-isoindole-1,3(2H)-dione chemical structure, C22H16BrNO3, CAS 301354-01-8
5-Bromo-2-[4-(2,3-dimethylphenoxy)phenyl]-1H-isoindole-1,3(2H)-dione
CAS 301354-01-8C22H16BrNO3
5-Bromo-2-[4-(4-chlorophenoxy)phenyl]isoindole-1,3-dione chemical structure, C20H11BrClNO3, CAS 306320-63-8
5-Bromo-2-[4-(4-chlorophenoxy)phenyl]isoindole-1,3-dione
CAS 306320-63-8C20H11BrClNO3
5-Nitro-2-(4-phenoxyphenyl)isoindole-1,3-dione chemical structure, C20H12N2O5, CAS 304455-41-2
5-Nitro-2-(4-phenoxyphenyl)isoindole-1,3-dione
CAS 304455-41-2C20H12N2O5
5,6-Dichloro-2-(4-phenoxyphenyl)isoindole-1,3-dione chemical structure, C20H11Cl2NO3, CAS 313259-57-3
5,6-Dichloro-2-(4-phenoxyphenyl)isoindole-1,3-dione
CAS 313259-57-3C20H11Cl2NO3
2-[4-(3-Methylphenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid chemical structure, C22H15NO5, CAS 351990-47-1
2-[4-(3-Methylphenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
CAS 351990-47-1C22H15NO5
5-Bromo-2-[4-(3-methylphenoxy)phenyl]isoindole-1,3-dione chemical structure, C21H14BrNO3, CAS 329195-85-9
5-Bromo-2-[4-(3-methylphenoxy)phenyl]isoindole-1,3-dione
CAS 329195-85-9C21H14BrNO3
2-[3-Chloro-4-(4-methylphenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid chemical structure, C22H14ClNO5, CAS 376624-65-6
2-[3-Chloro-4-(4-methylphenoxy)phenyl]-1,3-dioxoisoindole-5-carboxylic acid
CAS 376624-65-6C22H14ClNO5
2-[4-(4-tert-Butylphenoxy)phenyl]-1,3-dioxoisoindoline-5-carboxylic acid chemical structure, C25H21NO5, CAS 356087-74-6
2-[4-(4-tert-Butylphenoxy)phenyl]-1,3-dioxoisoindoline-5-carboxylic acid
CAS 356087-74-6C25H21NO5
2-(3-Chloro-4-phenoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylic acid chemical structure, C21H12ClNO5, CAS 377056-68-3
2-(3-Chloro-4-phenoxyphenyl)-1,3-dioxo-5-isoindolinecarboxylic acid
CAS 377056-68-3C21H12ClNO5
Methyl 2-(3-chloro-4-phenoxyphenyl)-1,3-dioxoisoindole-5-carboxylate chemical structure, C22H14ClNO5, CAS 356090-26-1
Methyl 2-(3-chloro-4-phenoxyphenyl)-1,3-dioxoisoindole-5-carboxylate
CAS 356090-26-1C22H14ClNO5
Ethyl 2-(3-chloro-4-phenoxyphenyl)-1,3-dioxoisoindole-5-carboxylate chemical structure, C23H16ClNO5, CAS 356090-29-4
Ethyl 2-(3-chloro-4-phenoxyphenyl)-1,3-dioxoisoindole-5-carboxylate
CAS 356090-29-4C23H16ClNO5
2-[4-(4-Methoxyphenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid chemical structure, C22H15NO6, CAS 521295-59-0
2-[4-(4-Methoxyphenoxy)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
CAS 521295-59-0C22H15NO6
2-[4-(4-tert-Butylphenoxy)phenyl]-4-nitroisoindole-1,3-dione chemical structure, C24H20N2O5, CAS 356089-61-7
2-[4-(4-tert-Butylphenoxy)phenyl]-4-nitroisoindole-1,3-dione
CAS 356089-61-7C24H20N2O5
2-[3-Chloro-4-(4-methylphenoxy)phenyl]isoindole-1,3-dione chemical structure, C21H14ClNO3, CAS 356090-58-9
2-[3-Chloro-4-(4-methylphenoxy)phenyl]isoindole-1,3-dione
CAS 356090-58-9C21H14ClNO3
Propyl 1,3-dioxo-2-(4-phenoxyphenyl)-5-isoindolinecarboxylate chemical structure, C24H19NO5, CAS 330979-95-8
Propyl 1,3-dioxo-2-(4-phenoxyphenyl)-5-isoindolinecarboxylate
CAS 330979-95-8C24H19NO5
Pentyl 1,3-dioxo-2-(4-phenoxyphenyl)isoindole-5-carboxylate chemical structure, C26H23NO5, CAS 330979-97-0
Pentyl 1,3-dioxo-2-(4-phenoxyphenyl)isoindole-5-carboxylate
CAS 330979-97-0C26H23NO5
2-[4-(4-Methylphenoxy)phenyl]-1H-isoindole-1,3(2H)-dione chemical structure, C21H15NO3, CAS 737795-18-5
2-[4-(4-Methylphenoxy)phenyl]-1H-isoindole-1,3(2H)-dione
CAS 737795-18-5C21H15NO3
2-(2-Nitro-4-phenoxyphenyl)-1H-isoindole-1,3(2H)-dione chemical structure, C20H12N2O5, CAS 352637-10-6
2-(2-Nitro-4-phenoxyphenyl)-1H-isoindole-1,3(2H)-dione
CAS 352637-10-6C20H12N2O5