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Murcko scaffold

1H-Indol-2-yl-(4-phenylpiperazin-1-yl)methanone scaffold

31 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
31
With full pages
12
Scaffold SMILES

O=C(c1cc2ccccc2[nH]1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1H-Indol-2-yl-(4-phenylpiperazin-1-yl)methanone page
Murcko scaffold O=C(c1cc2ccccc2[nH]1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(2-((1-methylethyl)amino)phenyl)- chemical structure, C22H26N4O, CAS 153473-50-8
Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(2-((1-methylethyl)amino)phenyl)-
CAS 153473-50-8C22H26N4O
1H-Indol-2-yl-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H21N3O2, CAS 153473-49-5
1H-Indol-2-yl-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 153473-49-5C20H21N3O2
[4-(2-Ethoxyphenyl)piperazin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone chemical structure, C22H25N3O3, CAS 136816-73-4
[4-(2-Ethoxyphenyl)piperazin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone
CAS 136816-73-4C22H25N3O3
1H-Indol-2-yl-(4-phenylpiperazin-1-yl)methanone chemical structure, C19H19N3O, CAS 57980-75-3
1H-Indol-2-yl-(4-phenylpiperazin-1-yl)methanone
CAS 57980-75-3C19H19N3O
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(1H-indol-2-yl)methanone chemical structure, C20H20ClN3O, CAS 1027535-73-4
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-(1H-indol-2-yl)methanone
CAS 1027535-73-4C20H20ClN3O
1-Methylindol-2-yl 4-phenylpiperazinyl ketone chemical structure, C20H21N3O, CAS 737792-90-4
1-Methylindol-2-yl 4-phenylpiperazinyl ketone
CAS 737792-90-4C20H21N3O
[4-(2-Fluorophenyl)piperazin-1-yl]-(6-methoxy-1H-indol-2-yl)methanone chemical structure, C20H20FN3O2, CAS 900274-79-5
[4-(2-Fluorophenyl)piperazin-1-yl]-(6-methoxy-1H-indol-2-yl)methanone
CAS 900274-79-5C20H20FN3O2
(5-Chloro-1H-indol-2-yl)-[4-(3-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H20ClN3O2, CAS 902046-66-6
(5-Chloro-1H-indol-2-yl)-[4-(3-methoxyphenyl)piperazin-1-yl]methanone
CAS 902046-66-6C20H20ClN3O2
(5-Fluoro-1H-indol-2-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C19H17F2N3O, CAS 902025-79-0
(5-Fluoro-1H-indol-2-yl)-[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 902025-79-0C19H17F2N3O
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(6-methoxy-1H-indol-2-yl)methanone chemical structure, C22H25N3O2, CAS 906261-67-4
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(6-methoxy-1H-indol-2-yl)methanone
CAS 906261-67-4C22H25N3O2
(6-Methoxy-1H-indol-2-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C21H23N3O3, CAS 902031-21-4
(6-Methoxy-1H-indol-2-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 902031-21-4C21H23N3O3
(5-Fluoro-1H-indol-2-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H20FN3O2, CAS 902043-39-4
(5-Fluoro-1H-indol-2-yl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 902043-39-4C20H20FN3O2
[4-(3-Chlorophenyl)piperazin-1-yl]-(5-fluoro-1H-indol-2-yl)methanone chemical structure, C19H17ClFN3O, CAS 902317-61-7
[4-(3-Chlorophenyl)piperazin-1-yl]-(5-fluoro-1H-indol-2-yl)methanone
CAS 902317-61-7C19H17ClFN3O
[4-(4-Fluorophenyl)piperazin-1-yl]-(6-methoxy-1H-indol-2-yl)methanone chemical structure, C20H20FN3O2, CAS 902335-83-5
[4-(4-Fluorophenyl)piperazin-1-yl]-(6-methoxy-1H-indol-2-yl)methanone
CAS 902335-83-5C20H20FN3O2
(6-Methoxy-1H-indol-2-yl)-[4-(3-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C21H23N3O3, CAS 902325-67-1
(6-Methoxy-1H-indol-2-yl)-[4-(3-methoxyphenyl)piperazin-1-yl]methanone
CAS 902325-67-1C21H23N3O3
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(5-fluoro-1H-indol-2-yl)methanone chemical structure, C21H22FN3O, CAS 900296-78-8
[4-(2,3-Dimethylphenyl)piperazin-1-yl]-(5-fluoro-1H-indol-2-yl)methanone
CAS 900296-78-8C21H22FN3O
(4-(2-Fluorophenyl)piperazin-1-yl)(1H-indol-2-yl)methanone chemical structure, C19H18FN3O, CAS 919729-68-3
(4-(2-Fluorophenyl)piperazin-1-yl)(1H-indol-2-yl)methanone
CAS 919729-68-3C19H18FN3O
[4-(2-Methoxyphenyl)piperazin-1-yl](1-methyl-1H-indol-2-yl)methanone chemical structure, C21H23N3O2, CAS 767302-47-6
[4-(2-Methoxyphenyl)piperazin-1-yl](1-methyl-1H-indol-2-yl)methanone
CAS 767302-47-6C21H23N3O2
5-Ethyl-1,3-dimethylindol-2-yl 4-(4-methoxyphenyl)piperazinyl ketone chemical structure, C24H29N3O2, CAS 941239-52-7
5-Ethyl-1,3-dimethylindol-2-yl 4-(4-methoxyphenyl)piperazinyl ketone
CAS 941239-52-7C24H29N3O2
[4-(4-Methoxyphenyl)piperazin-1-yl](1-methyl-1H-indol-2-yl)methanone chemical structure, C21H23N3O2, CAS 1190266-63-7
[4-(4-Methoxyphenyl)piperazin-1-yl](1-methyl-1H-indol-2-yl)methanone
CAS 1190266-63-7C21H23N3O2
[4-(3-Methoxyphenyl)piperazin-1-yl](1-methyl-1H-indol-2-yl)methanone chemical structure, C21H23N3O2, CAS 1190258-54-8
[4-(3-Methoxyphenyl)piperazin-1-yl](1-methyl-1H-indol-2-yl)methanone
CAS 1190258-54-8C21H23N3O2
5-Chloro-2-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-1H-indole chemical structure, C21H22ClN3O, CAS 1252912-11-0
5-Chloro-2-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-1H-indole
CAS 1252912-11-0C21H22ClN3O
(4,7-Dimethoxy-1-methyl-1H-indol-2-yl)[4-(4-fluorophenyl)piperazin-1-yl]methanone chemical structure, C22H24FN3O3, CAS 1351688-18-0
(4,7-Dimethoxy-1-methyl-1H-indol-2-yl)[4-(4-fluorophenyl)piperazin-1-yl]methanone
CAS 1351688-18-0C22H24FN3O3
(5-Fluoro-1-methyl-1H-indol-2-yl)[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C21H22FN3O2, CAS 1351702-28-7
(5-Fluoro-1-methyl-1H-indol-2-yl)[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 1351702-28-7C21H22FN3O2